Abstract
The effect of antrenylin on gastric secretion was studied in eight duodenal ulcers and one stomach ulcer. A single dose of 15 mg antrenylin resulted in a 50% reduction in fasting and basal secretions, but only an 18% decrease in acid levels. Accordingly, the 1-hour acid secretion decreased from 168 mgm to 64 mgm, a 62% decrease. Furthermore, gastric emptying time was doubled. Therefore, antrenylin's ulcer pain-relieving effect can be explained by its effect on motility rather than by reducing acidity. However, when antrenylin is administered with potassium-lowering drugs, the prolonged emptying time can result in a longer-lasting acidity in the stomach. Therefore, antrenylin is a useful adjunct in ulcer treatment.
References
- 1 — BACHRACH, W.H., ROWEN,B.R,, HALSTED, J. A, SHAPIRO,H. HOLMSTORM, W, and PRICE, P. (Citedin 2).
- 2 — BARRETT, W., RUTLEDGE,R,, PLUMMER, A. J. and YONKMAN, F. E. (1951) Trasentine analogues, inhibitors of gastric secretion, Fed. Proc, 10, 278.
- 3 — BEM, H, GROSS, F, SOHULER, H and TRIPOD, J. (1952) Pharmacologle differentiation of substances with parasympathicolytic and gangliönic blocking oeffecis as Obasis for their Üherapeutic use. Schweiz. Med. Wehnschbr,, 82, 1143,
- 4 — HENNİNG, N. (1952) Aerzti, Wesehr., 7, 665,
- ö— KAY,A, W. (1958) B.M.J. TL 77
- 6 — KİRSNER, J. B. AND PALMER, W. L. (1953) Newer gastric antisecretory compounds. J. Am, Med. Ass, 151, 798.
- 7 — ROGER, M. P. AND BARRETT, W. (1953) Laboratory and clinical evalua- tion of Antrenyl, a new anticholinergic drug, and its application to sur- , gery, Am. Surgeon, 19, 896.
- 8 — ROWEN,B.R, BAOHRACH, W. H., HALSTED, J. A, AND SHAPİRO, H, (1953) Studies on a new anticholinergic drug, Antrenyl,, Gastroentero- logy, 24, 88.
Abstract
Sekiz duodenum ve bir mide ülseri vakasında antrenylin mide ifrazı üzerine olan tesiri incelenmiştir. Tek doz halinde verilen 15 mgm. antrenyl, açlık ve bazal sekresyon miktarında %50 azalma husule getirmiş, fakat asit seviyesinde ancak %18 kadar bir düşme olmuştur. Buna göre ifraz edilen 1 saatlik asit miktarı 168 mgm. dan 64 mgm. a inmiş, yani %62 nisbetinde azalmıştır. Ayrıca midenin boşalma zamanı iki misli uzamıştır. Buna göre antrenylin ülser ağrısını giderici tesirini asiditeyi azaltmaktan ziyade motilite üzerine vaki tesiriyle izah mümkündür. Fakat antrenyl kalevi ilâçlarla bir- .
likte verildiği zaman, boşalma zamanının uzaması ile, midede daha uzun süren bir anasidite hali temin edilebilir. Bu bakımdan antrenyl ülser tedavisinde faideli bir yardımcıdır.
Keywords
References
- 1 — BACHRACH, W.H., ROWEN,B.R,, HALSTED, J. A, SHAPIRO,H. HOLMSTORM, W, and PRICE, P. (Citedin 2).
- 2 — BARRETT, W., RUTLEDGE,R,, PLUMMER, A. J. and YONKMAN, F. E. (1951) Trasentine analogues, inhibitors of gastric secretion, Fed. Proc, 10, 278.
- 3 — BEM, H, GROSS, F, SOHULER, H and TRIPOD, J. (1952) Pharmacologle differentiation of substances with parasympathicolytic and gangliönic blocking oeffecis as Obasis for their Üherapeutic use. Schweiz. Med. Wehnschbr,, 82, 1143,
- 4 — HENNİNG, N. (1952) Aerzti, Wesehr., 7, 665,
- ö— KAY,A, W. (1958) B.M.J. TL 77
- 6 — KİRSNER, J. B. AND PALMER, W. L. (1953) Newer gastric antisecretory compounds. J. Am, Med. Ass, 151, 798.
- 7 — ROGER, M. P. AND BARRETT, W. (1953) Laboratory and clinical evalua- tion of Antrenyl, a new anticholinergic drug, and its application to sur- , gery, Am. Surgeon, 19, 896.
- 8 — ROWEN,B.R, BAOHRACH, W. H., HALSTED, J. A, AND SHAPİRO, H, (1953) Studies on a new anticholinergic drug, Antrenyl,, Gastroentero- logy, 24, 88.
Details
| Primary Language | English |
|---|---|
| Subjects | Gastroenterology and Hepatology |
| Journal Section | Systematic Reviews and Meta Analysis |
| Authors | |
| Publication Date | December 30, 1955 |
| Published in Issue | Year 1955 Volume: 5 Issue: 1-4 |