HEPARIN TREATMENT IN ATHEROSCLEROTIC ANGINA PECTORIS SYNDROME

Year 1961, Volume: 14 Issue: 3, 1 - 6, 30.09.1961

Muzaffer Erman

Abstract

1—76 patients with atherosclerotic angina pectoris were treated with intravenous injections of 100 mg heparin twice weekly for 1.5-2 months. Sixteen of these 76 patients returned for follow-up. Four of these 16 patients showed complete clinical improvement. Obvious improvement was observed in the electrocardiograms of seven patients. Additionally, the effect of heparin on alimentary hyperlipemia induced by feeding fat to 10 patients with coronary sclerosis and four normal controls was investigated. Angina pectoris (in four cases), erythrocyte agglutination in the bulbar conjunctival vessels (in five cases), and electrocardiographic changes (in six cases) that occurred during the hyperlipemia phase returned to normal with intravenous injection of a small amount (50 mg) of heparin.
2 — The mechanism of action of heparin in ischemic angina pectoris has been debated.

Keywords

Heparin, Ischemic angina pectoris, Electrocardiogram

Aterosklerotik Angina Pectoris Sendromunda Heparin Tedavisi

Abstract

1—76 ateroskloretik angina pectoris'li hasta, haftada 2 defa 100 mg heparine damardan şırınga edilmek suretiyle 1,5-2 ay müddetle tedavi edilmiştir. 76 hastadan 16 tanesi tekrar kontrole gelmiştir. Bu 16 vakada 4'ünde tam klinik salah müşahede edilmiştir. 7 hastanın elektrokardiogramlarında aşikâr düzelme tesbit edilmiştir. Ayrıca 10 koroner sklerozlu hastaya ve 4 normal kontrol şahsa yağ yedirmek suretiyle, husule getirilen alimanter hiperlipemi üzerine heparinin tesiri incelenmiştir. Hiperlipemi safhasında meydana çıkan angina pectoris (4 vakada), bülber konjonktiva damarlarında eritrosit aglütinasyonu (5 vakada) ve elektrokardiografik değişiklikler (6 vakada) az miktarda (5o mg) heparinin damardan şırıngasiyle normale dönmüşlerdir.
2 — Heparinin iskemik angina pectoris'te tesir mekanizması münakaşa edilmiştir.

Keywords

Heparin, İskemik angina pektoris, Elektrokardiogram

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