Abstract
67 aterosklerotik hastaya günde 600 mg niacine, 1,5-2 aylık bir zaman süresince oral olarak verilmiştir. Bu gruptaki 10 hastada, tedaviden evvel, tedaviden 6 ve 8 hafta sonra kolesterolemi, total lipidemi, fosfolipedemi tayin edilmiş ve Kunkel fenol testi yapılmıştır. 10 hastada günde 600 mg dozunda niacine tedavisinden 6 hafta sonra, total
kolesterolemide yüzde 25,1 mg kadar bir azalma tesbit edilmiştir. 8 hafta sonunda ortalama kolesterolemide, 6 hafta sonraki kolesterolemiden farklı bir değişiklik tesbit edilmemiştir. Ayaktan takip edilen 57 hastadan 12 tanesi bir yıl içinde tekrar kontrole gelmiştir. Bu grupta yalnız kolesterol tayini yapılmıştır. Günde 600 mg dozunda ortalama 2.9 aylık bir niacine tedavisi sonunda, total kolesterolemide ortalama yüzde 30,2 mg bir azalma müşahede edilmiştir.
References
- AlrscuuL, R., Hoffer, A., Stephen, A.J.D.: Arch. Biochem. 54: 558, 1955.
- AlrsomuL, R.: Circulation, 14: 494, 1956 (abstract).
- Merritt, M. et al.: Circulation, 16: 915, 1957.
- O'Reilly, P.O., Demay, M., Kerlewski, K.: A.M.A. Arch. Intern. Med. 100: 797, 1957.
- Persons, W.B. et al.: Circulation, 14: 495, 1956.
- Person, W.B.: J.A.M.A. 165: 1234, 1957.
- Acuor, R.W.P., Berge, K., Barker, N.W., McKenzie, B.P.: Circulation 17: 497, 1955.
- Shade, H., Saltman: Proc. Soc. Exp. Biol. Med. 102: 265, 1959.
- Gymeli, K.: Acta Med. Scandinav. 16: 55, 1960.
Abstract
Sixty-seven atherosclerotic patients were given 600 mg of niacine orally daily for 1.5-2 months. Cholesterolemia, total lipidemia, and phospholipidemia were determined before, 6, and 8 weeks after treatment, and the Kunkel phenol test was performed in 10 patients in this group. After 6 weeks of niacine treatment at a dose of 600 mg per day, a 25.1 mg percent reduction in total cholesterol was observed in 10 patients. After 8 weeks, no change in mean cholesterolemia was observed compared to the 6-week mean cholesterol level. Of the 57 outpatients, 12 patients returned for follow-up within one year. Only cholesterol was measured in this group. After an average of 2.9 months of niacine treatment at a dose of 600 mg per day, a mean reduction in total cholesterolemia of 30.2 mg percent was observed.
References
- AlrscuuL, R., Hoffer, A., Stephen, A.J.D.: Arch. Biochem. 54: 558, 1955.
- AlrsomuL, R.: Circulation, 14: 494, 1956 (abstract).
- Merritt, M. et al.: Circulation, 16: 915, 1957.
- O'Reilly, P.O., Demay, M., Kerlewski, K.: A.M.A. Arch. Intern. Med. 100: 797, 1957.
- Persons, W.B. et al.: Circulation, 14: 495, 1956.
- Person, W.B.: J.A.M.A. 165: 1234, 1957.
- Acuor, R.W.P., Berge, K., Barker, N.W., McKenzie, B.P.: Circulation 17: 497, 1955.
- Shade, H., Saltman: Proc. Soc. Exp. Biol. Med. 102: 265, 1959.
- Gymeli, K.: Acta Med. Scandinav. 16: 55, 1960.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Articles |
| Authors | |
| Publication Date | September 30, 1961 |
| Published in Issue | Year 1961 Volume: 14 Issue: 3 |