Göz Tümörlerinin Radyoaktif Fosfor (P32) Uptake Metodu ile Araştırılması

Year 1964, Volume: 17 Issue: 1, 35 - 50, 31.03.1964

Yavuz Tarcan

Abstract

Klinik olarak 12 si göz tümörü ve 1 tanesi hemanjiyom düşünülen
en genci 2,5 en yaşlısı 70 olan 4 ü kadın 9 u erkek 13 vak'ada
Radyoaktif Fosfor (P 32) Testi kullanıldı. Tümör teşhisi konulan 7
vak'anın 3 ünde bu bulguların patoloji raporu ile doğrulanmasına
mukabil 1 inde «Keratit Sekeli» 3 ünde hastaların ameliyatı istememelerinden
dolayı vatolojik muayene hakkında bilgi edinilemedi. Tümör
ekarte edilen 4 vak'adan 2 sinin bulguları «Göz Hemorajisi» ve
«Retina Dekolmanı» olarak patoloji raporu ile tevsik edildiği halde 2
vak'ada patolojik muayene yine aynı sebepden dolayı elde edilemedi.
Şüpheli görülen 2 hudut vak'asında denükleasyon yapılmadığından
test hakkında kesin bir bilgi elde olunamadı.
Eksternal beta ışınları sayım farklarına dayanan bu testin,
testte özel ve hassas göz detektörleri kullanılması ve ayni zamanda
göz kapaklarının oftalmolojik metodlar ile mümkün olduğu kadar
açılması ve göz yuvarlağının hiç değilse 50 - 60 derece laterale çekilmesi
suretiyle daha hassas sayımlar elde edilebileceği düşünülerek
bu testin maling göz tümörlerinin teşhisinde daha faydalı olacağı
kanaatına varıldı.

Keywords

Göz tümörleri , Radyoaktif fosfor (P32) , Beta ışınları

Diagnosis of Eye Tumors By Means of (P32) Uptake Method

Abstract

The Radioactive Phosphorus (P 32) test was used in 13 cases, including 12 with ocular tumors and 1 with hemangioma. The youngest was 2.5 years old and the oldest was 70 years old, with 4 women and 9 men. While these findings were confirmed by pathology reports in 3 of the 7 cases diagnosed with tumors, information on the vascular examination was not available due to the presence of "keratitis sequelae" in 1 case and the patient's refusal to undergo surgery in 3 cases. Although the findings in 2 of the 4 cases in which tumors were ruled out were documented in the pathology reports as "eye hemorrhage" and "retinal detachment," pathological examinations were not available in 2 cases for the same reason.
Denucleation was not performed in the 2 suspected borderline cases, and definitive information regarding the test could not be obtained. It was concluded that this test, based on external beta ray count differences, would be more useful in diagnosing malignant eye tumors. It was believed that more accurate counts could be obtained by using special and sensitive eye detectors, simultaneously opening the eyelids as much as possible using ophthalmological methods, and retracting the eyeball at least 50-60 degrees laterally.

Keywords

Eye tumors , Radioactive phosphorus (P32) , Beta rays

References

• 1. Marshak A, Uptake of Radioactive Phosphorus by Nuclei of Liver and Tumors, Science 92, 460-461 (Nov. 15) 1940.
• 2. Kenny J. M., Marinelli L. D., and Woodard H. A., Tracer Studies with Radioactive Phosphorus in Malignant Neoplastic Diseases, Radiology, 37, 683-687 (Dec.) 1941.
• 3. Marinelli L. D., and Goldschmith, B, Concentration of P32 in some Superficial Tissue of Living Patients, Radiology 39,454-463 (Oct.) 1942.
• 4. Low-Beer B.V., Bell H.G., Mc Corkle H.J., and Stone, R.S., Measurement of Radioactive Phosphorus in Breast Tumors in Situ, a possible Diagnostic Procedure, Radiology 47, 492-493 (Nov.) 1946.
• 5. Thomas C.I., Kroher J.S., and Storasil J.P., Detection of Intraocular Tumors with P32, A.M. Arch. Ophthal. 47, 276-286, 1952.
• 6. Bettman J.W., and Fellows, V. Radioactive Phosphorus as a Diagnostic aid in Ophthalmology, Arch. Ophthal. 51, 171, 1954.
• 7. Owens W.C., King J.H., Jr, and Wells H.S., Radioactive Phosphorus for the Detection of Intraocular Tumors, Am. Jour. of Ophthal. 41, 507, 1956.
• 8. Eisenberg I. J., Leopold I. H, and Sklaroff, D. Use of Radioactive Phosphorus in Detection of Intraocular Neoplasms, A.M.A. Arch. Ophthal. 51, 633-641, 1954.
• 9. Terner, I. S., Leopold I. H., and Eisenberg I. J., The Radioactive Phosphorus Uptake Test in Ophthalmology, A Review of the Literature and Analysis of Results in 1962 Cases of Ocular and Adnexal Pathology, Arch. Ophthal. 55, 52, 1956.
• 10. Goldberg B., Tobowitz, D, Kara G.A., Zavell, S., and Espiritu, R., The Use of P32 in the Diagnosis of Ocular Tumors, Arch. Ophthal. 65, 196, 1961.