Infantile Megaloblastic Anemia – Review of 10 Cases

Year 1965, Volume: 18 Issue: 2, 361 - 379, 30.06.1965

Ayhan Okçuoğlu

Abstract

1957–1962 yılları arasında Ankara Üniversitesi Çocuk Kliniği’nde tedavi edilen 10 infantil megaloblastik anemi vakası sunulmuştur. Hastaların çoğu bir yaş civarındadır ve beslenme yetersizliği ile enfeksiyon geçmişi bulunmaktadır. Tipik bulgular arasında solukluk, gelişme geriliği, hepatomegali ve megaloblastik kemik iliği displazisi yer alır. Tedaviye folik asit ile yanıt alınmış, bazı vakalarda transfüzyon ve ek olarak C vitamini veya B12 kullanılmıştır. İki vakada tedaviye yanıt alınamamış, bir vakada thalassemia major eşlik etmiştir. Bulgular Türkiye'de infantil megaloblastik aneminin zannedilenden yaygın olduğunu düşündürmektedir.

Infantil Megaloblastik Anemi – 10 Vak’a Münasebetiyle

Abstract

Clinical and hematologic findings of 10 infants diagnosed with megaloblastic anemia are presented. Most cases were around 1 year of age, with histories of nutritional deficiency and infection. Hallmark signs included pallor, growth delay, hepatomegaly, and megaloblastic bone marrow dysplasia. Folic acid was the main treatment, with some cases receiving transfusion, vitamin C, or B12. Two cases did not respond to therapy; one case was complicated by thalassemia major. Findings suggest that infantile megaloblastic anemia is more prevalent in Turkey than commonly assumed.

Keywords

Infantil anemi, megaloblastik anemi, folik asit, B12 vitamini, enfeksiyon

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