The Transplantation of Spontaneous Mammary Carcinoma of Mice, II – Study of Influence of Transplants on the Mammary Tissue of Mice

Year 1967, Volume: 20 Issue: 3, 370 - 380, 30.09.1967

Orhan Bulay

Abstract

Bu çalışma, spontan meme kanseri transplantlarının fare meme dokusu üzerindeki etkisini incelemektedir. Toplamda 171 İsviçre tipi beyaz fare (82 erkek, 89 dişi) kullanılmıştır. Transplantlar 44 erkekte ve 35 dişide başarıyla tutmuştur. Meme dokusu üzerindeki etki oldukça sınırlıdır; esas olarak duktus epitelinde proliferasyon şeklinde gözlenmiştir. Transplantasyonun prekanseröz lobülo-alveoler yapıların oluşumuna sebep olmadığı saptanmıştır. Bu yapıların oluşumu yaşla bağlantılı olarak artmaktadır, ancak transplant doğrudan etkili değildir.

Keywords

transplantasyon, lobülo-alveoler yapılar, duktus proliferasyonu

Spontan Meme Kanserlerinin Transplantasyonu, II – Transplantın Meme Dokusu Üzerindeki Etkisinin Araştırılması

Abstract

This study investigates the effect of spontaneous mammary carcinoma transplants on mouse mammary tissue. A total of 171 Swiss white mice (Ankara type), including 82 males and 89 females, were used. Transplants successfully engrafted in 44 males and 35 females. The impact on mammary tissue was limited, primarily manifesting as epithelial proliferation in the ducts. There was no significant formation of precancerous lobulo-alveolar structures due to transplantation. These structures were found to increase with age, but not as a direct result of transplant influence.

Keywords

Spontaneous mammary carcinoma, transplantation, lobulo-alveolar structures, ductal proliferation

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