Serum Amylase Determination in Children with Infectious Hepatitis

Year 1967, Volume: 20 Issue: 3, 399 - 405, 30.09.1967

Binnaz Ege

Abstract

Bu çalışmada, yaşları 4 ile 12 arasında değişen 43 enfeksiyöz hepatitli çocukta hastalığın akut ve şifa safhalarında serum amilaz seviyeleri değerlendirilmiştir. Tüm vakalarda akut safhada serum amilaz değerleri normalden düşük bulunmuş, şifa halinde ise normale dönmüştür. Bulgular, karaciğerin amilaz regulasyonunda özellikle hastalık döneminde önemli rol oynadığını göstermektedir. Düşük serum amilazın sebebi olarak hepatik hücre hasarının yol açtığı anormal glikojen yıkımı sonucu karaciğerin amilazı daha fazla kullanması öne sürülmektedir. Konuyla ilgili çelişkili literatür verileri de ele alınmıştır.

Enfeksiyöz Hepatit Gösteren Çocuklarda Serum Amilaz Seviyesinin Tetkiki

Abstract

This study evaluates serum amylase levels in 43 children (aged 4–12) diagnosed with infectious hepatitis during both the acute and recovery phases. In all cases, serum amylase levels were significantly lower than normal during the acute phase, returning to normal during recovery. The findings suggest that the liver plays a critical role in amylase regulation, especially under pathological conditions. Potential mechanisms include increased hepatic utilization of amylase due to cell damage, leading to reduced serum concentrations. Previous research supporting both low and high serum amylase levels in hepatic conditions is discussed, highlighting the complexity of liver-enzyme interactions.

Keywords

Infectious hepatitis, serum amylase, liver function, glycogenolysis

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