Research Article
BibTex RIS Cite

İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme

Year 1982, Volume: 35 Issue: 1, 13 - 24, 31.03.1982

Abstract

This study evaluates the effectiveness of intrathecal morphine administration in managing labor pain. The research was conducted on 12 multiparous women without systemic disorders. Findings demonstrate that morphine provides substantial analgesic effect without impairing uterine contractions or neonatal vital parameters. However, common maternal side effects—including dizziness, somnolence, nausea, and pruritus—were observed. Considering the severity and duration of these effects, the routine use of intrathecal morphine for obstetric analgesia may present significant risks.

References

  • 1. Alper MH : Intrathecal Morphine : A new method of obstetrica analgesia, (Editorial) *Anesthesiology* 51 : 378, 1979.
  • 2. Atweh SF, Kuhar MJ : Autoradiographis localisation of opiate receptors in rat brain, I. Spinal cord and lower medulla, *Brain Res.* 123 : 53. 1977.
  • 3. Baraka A, Noueihid R, Hajj S : Intrathecal injection of morphine for obstetric analgesia, *Anesthesiology* 54 : 136, 1981.
  • 4. Barron DW, Strong JE : Postoperative analgesia in major orthopaedic surgery, *Anaesthesia* 36 : 937, 1981.
  • 5. Brooker P, Wilkes RG, Bryson THL, Beddard J : Clinical experiences with epidural morphine, *Anaesthesia* 35 : 1129, 1980.
  • 6. Bromage PR, Camporesi E, Chestnut D : Epidural narcotics for postoperative analgesia, *Anesth Analg* 59 : 473, 1980.
  • 7. Christensen V : Respiratory depression after extradural morphine, *Brit J Anaesth* 52 : 841, 1980.
  • 8. Collins V : *Principles of anesthesiology*, Lea and Febiger, Philadelphia, 1976 (Second edition).
  • 9. Crawford JS : Site of action of intrathecal morphine, *Lancet* II : 357, 1979.
  • 10. Crawford JS : Intrathecal morphine in obstetrics, *Anesthesiology* 55 : 487, 1981.
  • 11. Crawford JS : Experiences with epidural morphine in obstetrics, *Anaesthesia* 36 : 207, 1981.
  • 12. Davies GK, Tolhurst-Cleaver CL, James TL : CNS depression from intrathecal morphine, *Anesthesiology* 52 : 280, 1980.
  • 13. Glynn CL, Mather LE, Cousin MJ : Spinal narcotics and respiratory depression, *Lancet* II : 357, 1979.
  • 14. Gjessing J, Toulin PJ : Postoperative pain control with intrathecal morphine, *Anaesthesia* 36 : 263, 1981.
  • 15. Graham JL, King R, McCaughey W : Postoperative pain relief using epidural morphine, *Anaesthesia* 35 : 158, 1980.
  • 16. Husemeyer RP, O'Connor MC, Davenport HT : Failure of epidural morphine to relieve pain in labor, *Anaesthesia* 35 : 161, 1980.
  • 17. Jones RDM, Jones JG : Intrathecal morphine. Naloxone reverses respiratory depression but not analgesia, *Brit M J* 281 : 645, 1981.
  • 18. Kitahata LM, Collins JG : Spinal action of narcotic analgesics, *Anesthesiology* 54 : 153, 1981.
  • 19. Le Bars D, Menetrey D, Conseiller C, Besson JM : Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat, *Brain Res* 98 : 261, 1975.
  • 20. Le Bars D, Guilbaud G, Jurna I, Besson JM : Differential effects of morphine on response of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat, *Brain Res* 115 : 518, 1976.
  • 21. Liolios A, Andersen FH : Selective spinal analgesia, *Lancet* II : 357, 1979.
  • 22. Mok MS, Tsai SK : More experience with intrathecal morphine for obstetric analgesia, *Anesthesiology* 55 : 481, 1981.
  • 23. Pert CB, Synder SH : Opiate receptors: Demonstration in nervous tissue, *Science* 179 : 1011, 1973.
  • 24. Pert CB, Synder SH : Properties of opiate receptor binding in rat brain, *Proc Nat Acad* 70 : 2243, 1973.
  • 25. Samii K, Chauvin M, Viars P : Postoperative spinal analgesia with morphine, *Brit J Anaesth* 57 : 817, 1981.
  • 26. Samii K, Feret J, Harari A : Selective spinal analgesia, *Lancet* 126 : 1142, 1979.
  • 27. Stephen JW, Richard RR : Serum levels following epidural administration of morphine and correlation with relief of postsurgical pain, *Anesthesiology* 54 : 210, 1981.
  • 28. Wang JK : Analgesic effect of intrathecally administered morphine, *Reg Anesth* 2 : 3, 1977.
  • 29. Wang JG, Nauss LA, Thomas JE : Pain relief by intrathecally applied morphine in man, *Anesthesiology* 50 : 149, 1979.
  • 30. Writer WD, James FM, Wheeler AS : Double-blind comparison of morphine and bupivacaine for continuous epidural analgesia in labor, *Anesthesiology* 54 : 215, 1981.
  • 31. Wylie WD, Churchill-Davidson HC : *A practice of anaesthesiology*, Lloyd-Luke Ltd, London, 1972, p.1407–1439.
  • 32. Yaksh TL : Analgesic action of intrathecal opiates in cat and primate, *Brain Res* 153 : 205, 1978.
  • 33. Yaksh TL, Rudy TA : Narcotic analgesics: CNS sites and mechanism of action as revealed by intrathecal injection technique, *Pain* 4 : 299, 1977.
  • 34. Yaksh TL, Rudy TA : Analgesia mediated by a direct spinal action of narcotics, *Science* 192 : 1357, 1976.
  • 35. Yaksh TL, Wilson PR, Kaiko RF, Inturrisi CE : Analgesia produced by a spinal action of morphine and effects upon parturition in the rat, *Anesthesiology* 51 : 386, 1979.

Effects of Intrathecal Morphine Administration on Labor Analgesia: Clinical Observations and Evaluation

Year 1982, Volume: 35 Issue: 1, 13 - 24, 31.03.1982

Abstract

Bu çalışma, doğum sırasında ağrının giderilmesine yönelik olarak intratekal morfin uygulamasının etkinliğini değerlendirmektedir. Araştırma, sistemik hastalığı olmayan 12 multipar gebe üzerinde gerçekleştirilmiştir. Sonuçlar, morfinin doğum ağrısı üzerinde güçlü analjezik etki sağladığını; doğum sürecinde uterus kontraksiyonlarının olumsuz etkilenmediğini ve bebeklerin vital bulgularının normal kaldığını göstermektedir. Ancak annelerde baş dönmesi, uykuya eğilim, bulantı ve kaşıntı gibi yan etkiler yaygın şekilde gözlemlenmiştir. Yan etkilerin şiddeti ve süresi dikkate alındığında, intratekal morfinin doğum analjezisi için rutin kullanımı sakıncalar taşıyabilir.

References

  • 1. Alper MH : Intrathecal Morphine : A new method of obstetrica analgesia, (Editorial) *Anesthesiology* 51 : 378, 1979.
  • 2. Atweh SF, Kuhar MJ : Autoradiographis localisation of opiate receptors in rat brain, I. Spinal cord and lower medulla, *Brain Res.* 123 : 53. 1977.
  • 3. Baraka A, Noueihid R, Hajj S : Intrathecal injection of morphine for obstetric analgesia, *Anesthesiology* 54 : 136, 1981.
  • 4. Barron DW, Strong JE : Postoperative analgesia in major orthopaedic surgery, *Anaesthesia* 36 : 937, 1981.
  • 5. Brooker P, Wilkes RG, Bryson THL, Beddard J : Clinical experiences with epidural morphine, *Anaesthesia* 35 : 1129, 1980.
  • 6. Bromage PR, Camporesi E, Chestnut D : Epidural narcotics for postoperative analgesia, *Anesth Analg* 59 : 473, 1980.
  • 7. Christensen V : Respiratory depression after extradural morphine, *Brit J Anaesth* 52 : 841, 1980.
  • 8. Collins V : *Principles of anesthesiology*, Lea and Febiger, Philadelphia, 1976 (Second edition).
  • 9. Crawford JS : Site of action of intrathecal morphine, *Lancet* II : 357, 1979.
  • 10. Crawford JS : Intrathecal morphine in obstetrics, *Anesthesiology* 55 : 487, 1981.
  • 11. Crawford JS : Experiences with epidural morphine in obstetrics, *Anaesthesia* 36 : 207, 1981.
  • 12. Davies GK, Tolhurst-Cleaver CL, James TL : CNS depression from intrathecal morphine, *Anesthesiology* 52 : 280, 1980.
  • 13. Glynn CL, Mather LE, Cousin MJ : Spinal narcotics and respiratory depression, *Lancet* II : 357, 1979.
  • 14. Gjessing J, Toulin PJ : Postoperative pain control with intrathecal morphine, *Anaesthesia* 36 : 263, 1981.
  • 15. Graham JL, King R, McCaughey W : Postoperative pain relief using epidural morphine, *Anaesthesia* 35 : 158, 1980.
  • 16. Husemeyer RP, O'Connor MC, Davenport HT : Failure of epidural morphine to relieve pain in labor, *Anaesthesia* 35 : 161, 1980.
  • 17. Jones RDM, Jones JG : Intrathecal morphine. Naloxone reverses respiratory depression but not analgesia, *Brit M J* 281 : 645, 1981.
  • 18. Kitahata LM, Collins JG : Spinal action of narcotic analgesics, *Anesthesiology* 54 : 153, 1981.
  • 19. Le Bars D, Menetrey D, Conseiller C, Besson JM : Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat, *Brain Res* 98 : 261, 1975.
  • 20. Le Bars D, Guilbaud G, Jurna I, Besson JM : Differential effects of morphine on response of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat, *Brain Res* 115 : 518, 1976.
  • 21. Liolios A, Andersen FH : Selective spinal analgesia, *Lancet* II : 357, 1979.
  • 22. Mok MS, Tsai SK : More experience with intrathecal morphine for obstetric analgesia, *Anesthesiology* 55 : 481, 1981.
  • 23. Pert CB, Synder SH : Opiate receptors: Demonstration in nervous tissue, *Science* 179 : 1011, 1973.
  • 24. Pert CB, Synder SH : Properties of opiate receptor binding in rat brain, *Proc Nat Acad* 70 : 2243, 1973.
  • 25. Samii K, Chauvin M, Viars P : Postoperative spinal analgesia with morphine, *Brit J Anaesth* 57 : 817, 1981.
  • 26. Samii K, Feret J, Harari A : Selective spinal analgesia, *Lancet* 126 : 1142, 1979.
  • 27. Stephen JW, Richard RR : Serum levels following epidural administration of morphine and correlation with relief of postsurgical pain, *Anesthesiology* 54 : 210, 1981.
  • 28. Wang JK : Analgesic effect of intrathecally administered morphine, *Reg Anesth* 2 : 3, 1977.
  • 29. Wang JG, Nauss LA, Thomas JE : Pain relief by intrathecally applied morphine in man, *Anesthesiology* 50 : 149, 1979.
  • 30. Writer WD, James FM, Wheeler AS : Double-blind comparison of morphine and bupivacaine for continuous epidural analgesia in labor, *Anesthesiology* 54 : 215, 1981.
  • 31. Wylie WD, Churchill-Davidson HC : *A practice of anaesthesiology*, Lloyd-Luke Ltd, London, 1972, p.1407–1439.
  • 32. Yaksh TL : Analgesic action of intrathecal opiates in cat and primate, *Brain Res* 153 : 205, 1978.
  • 33. Yaksh TL, Rudy TA : Narcotic analgesics: CNS sites and mechanism of action as revealed by intrathecal injection technique, *Pain* 4 : 299, 1977.
  • 34. Yaksh TL, Rudy TA : Analgesia mediated by a direct spinal action of narcotics, *Science* 192 : 1357, 1976.
  • 35. Yaksh TL, Wilson PR, Kaiko RF, Inturrisi CE : Analgesia produced by a spinal action of morphine and effects upon parturition in the rat, *Anesthesiology* 51 : 386, 1979.
There are 35 citations in total.

Details

Primary Language English
Subjects Pain
Journal Section Articles
Authors

Handan Cuhruk This is me

Publication Date March 31, 1982
Published in Issue Year 1982 Volume: 35 Issue: 1

Cite

APA Cuhruk, H. (1982). İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 35(1), 13-24.
AMA Cuhruk H. İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme. Ankara Üniversitesi Tıp Fakültesi Mecmuası. March 1982;35(1):13-24.
Chicago Cuhruk, Handan. “İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular Ve Değerlendirme”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35, no. 1 (March 1982): 13-24.
EndNote Cuhruk H (March 1, 1982) İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35 1 13–24.
IEEE H. Cuhruk, “İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 35, no. 1, pp. 13–24, 1982.
ISNAD Cuhruk, Handan. “İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular Ve Değerlendirme”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35/1 (March 1982), 13-24.
JAMA Cuhruk H. İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1982;35:13–24.
MLA Cuhruk, Handan. “İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular Ve Değerlendirme”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 35, no. 1, 1982, pp. 13-24.
Vancouver Cuhruk H. İntratekal Morfin Uygulamasının Doğum Analjezisi Üzerindeki Etkileri: Klinik Bulgular ve Değerlendirme. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1982;35(1):13-24.