Akut gastroenteritli bebeklerde sekonder laktoz toleransı

Year 1982, Volume: 35 Issue: 2, 377 - 384, 01.07.1982

Nazım Önder

Abstract

Sekonder karbonhidrat malabsorbsiyon sendromları pek çok bağırsak ve bağırsak dışı hastalıkla birliktedir. En sık gözlenen formu sekonder laktoz intoleransı olup, laktaz enziminin ince bağırsak epitelindeki yüzeyel konumu ve düşük konsantrasyonu nedeniyle klinikte en sık rastlanan disakkaridaz bozukluğudur. Bu çalışmada, 2–18 ay arasında akut gastroenteritli 25 bebek ile herhangi bir hastalığı olmayan 20 kontrol olgusunda sekonder laktoz intoleransı değerlendirilmiştir. Tüm olgulara oral laktoz tolerans testi uygulanmış; sonrasında diyare gözlemi, kan şekeri artışı, gaita pH’sı ve redüktan madde varlığı gibi kriterler dikkate alınmıştır. Bulgular, gastroenteritli grupta laktoz intoleransının kontrol grubuna göre anlamlı olarak daha fazla olduğunu göstermiştir (P<0.05).

Keywords

Sekonder laktoz intoleransı, akut gastroenterit, bebekler, laktaz eksikliği, oral laktoz tolerans testi, gaita pH’sı, redüktan madde, karbonhidrat malabsorbsiyonu

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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Secondary Lactose Intolerance in Infants with Acute Gastroenteritis

Abstract

Secondary carbohydrate malabsorption syndromes are associated with a number of intestinal and extraintestinal diseases. Secondary lactose malabsorption is the most frequent alteration due to the superficial location and low concentration of lactase in the intestinal epithelium. In this study, secondary lactose intolerance was evaluated in 25 infants aged 2–18 months with acute gastroenteritis, and 20 healthy controls. All subjects underwent oral lactose tolerance testing; subsequent criteria such as diarrhea presence, blood glucose rise, stool pH, and reducing substances were assessed. Results showed secondary lactose intolerance was significantly higher in the gastroenteritis group than in controls (P<0.05).

Keywords

Secondary lactose intolerance, acute gastroenteritis, infants, lactase deficiency, oral lactose tolerance test, stool pH, reducing substances, carbohydrate malabsorption

Project Number

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References

• 1 - Ament M. : Intestinal Malabsorbtion : In Nelson, W.E., Vaughan, V.C., McKay, R.J Behrman, R.E. (eds) : Textbook of Pediatrics. 11 th ed. Philedelphia, IÃ1don, Toronto, w.B. Saunders Company, 1979, P. 1075.
• 2 - Barthrop, W., Hull, D. : Transient Lactose Intolerance in Infancy. Arch. Dis. Child. 48 : 963, 1973.
• 3 - Gray, G.M. : Corbohydrate Digestion and Absorbtion. Role of the Small Intestine. N. Engl. J. Med. 292 : 1225, 1975.
• 4 - Kretchmer, N. : Lactose and Lactase. Sci. Am. 227 : 70, 1972.
• 5 _ Lifshitz, F. : Carbohyrate Porblems in Paediatric Gastroenterology. Clin. Gastroenterol. 6 : 415, 1977.
• 6 - Lifshitz, F., Coello-Ramirez, P., Contreras-Gutierrez, M.L. : The Response of Infants to Carbohydrate Oral Loads after Recovery from Diarrhea. J. Pediat. 79 : 612, 1971.
• 7 - Lifshitz, F. Coello-Ramirez, P., Gutierrez-Topete, G., Cornado-Cornet, M.C. : Carbohydrate Intolerance in Infants with Diarrhea. J. Pediatr. 79 : 760, 1971.
• 8 - Lugo-de-Rivero, C., Rodriguez, H., Torres-Pinedo, R. : Studies on the Mechanism of Sugar Malabsorbtion in Infantil Infectious Diarrhea. Am. J. Clin. Nutr. 25 : 1248, 1972.
• 9 - McBi11, D.B., Newcomer, A.D. : Comparisons of Venous and Capillary Blood Samples in Lastose Tolerance Testing. Gastroenterology 53 : 371 1967.
• 10 - McMichael, H.B. : Disorders of Carbohydrate Digestion and Absorbtion. Clin. Endocrinol. 5 : 627, 1976.
• Il - Reddy, V., Pershad, J. : Lactase Deficiency in Indians. Am. J. Clin. Nutr. 25 • 114, 1972. 384 Sarıbaş
• 12 - Silverman, A, Ro y CC, Couetto, F.J. : Pediatric Clinical Gastroenterology. Saint Louis, CV. Mosby Company, 1971, P.- 149.
• 1 - Ament M. : Intestinal Malabsorbtion : In Nelson, W.E., Vaughan, V.C., McKay, R.J Behrman, R.E. (eds) : Textbook of Pediatrics. 11 th ed. Philedelphia, IÃ1don, Toronto, w.B. Saunders Company, 1979, P. 1075.
• 2 - Barthrop, W., Hull, D. : Transient Lactose Intolerance in Infancy. Arch. Dis. Child. 48 : 963, 1973.
• 3 - Gray, G.M. : Corbohydrate Digestion and Absorbtion. Role of the Small Intestine. N. Engl. J. Med. 292 : 1225, 1975.
• 4 - Kretchmer, N. : Lactose and Lactase. Sci. Am. 227 : 70, 1972.
• 5 _ Lifshitz, F. : Carbohyrate Porblems in Paediatric Gastroenterology. Clin. Gastroenterol. 6 : 415, 1977.
• 6 - Lifshitz, F., Coello-Ramirez, P., Contreras-Gutierrez, M.L. : The Response of Infants to Carbohydrate Oral Loads after Recovery from Diarrhea. J. Pediat. 79 : 612, 1971.
• 7 - Lifshitz, F. Coello-Ramirez, P., Gutierrez-Topete, G., Cornado-Cornet, M.C. : Carbohydrate Intolerance in Infants with Diarrhea. J. Pediatr. 79 : 760, 1971.
• 8 - Lugo-de-Rivero, C., Rodriguez, H., Torres-Pinedo, R. : Studies on the Mechanism of Sugar Malabsorbtion in Infantil Infectious Diarrhea. Am. J. Clin. Nutr. 25 : 1248, 1972.
• 9 - McBi11, D.B., Newcomer, A.D. : Comparisons of Venous and Capillary Blood Samples in Lastose Tolerance Testing. Gastroenterology 53 : 371 1967.
• 10 - McMichael, H.B. : Disorders of Carbohydrate Digestion and Absorbtion. Clin. Endocrinol. 5 : 627, 1976. Il - Reddy, V., Pershad, J. : Lactase Deficiency in Indians. Am. J. Clin. Nutr. 25 • 114, 1972. 384 Sarıbaş 12 - Silverman, A, Ro y CC, Couetto, F.J. : Pediatric Clinical Gastroenterology. Saint Louis, CV. Mosby Company, 1971, P.- 149.