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Benign Trofoblastik Hastalıklar 30 Vakanın Analizi

Year 1972, Volume: 25 Issue: 3, 473 - 489, 30.09.1972

Hikmet Yavuz

Abstract

Bu incelememizde 1950-1971 yılları arasında kliniğimizde 15232 adet obstetrikal vaka içerisinde teşhisi konan ve tedavi edilen 28 adet mol ve 2 adet koryoadenoma destruens vakası ele alınmış ve her 544 gebeliğe bir adet mol düştüğü saptanmıştır. Molar gebelik teşhisi ve tedavisinde kullanılan metodlar, vakalarımızın klinik özellikleri, alınan tedavi sonuçları literatürdeki bulgularla karşılaştırı- larak vardığımız sonuçlar belirtilmeye çalışılmıştır. Molar gebeliğin yine trofoblastik bir hastalık olmakla beraber, aşırı malign bir nitelik taşıması dolayısiyle kadın hayatı için çok tehlikeli bir neoplazma olan koryokarsinomaya dönüşebilmesi ihtimali her zaman varolduğundan, tedavisine özel bir önem verilmesi gerekmektedir. Bu amaçla vakalarımızdan bir kısmında tedaviden sonra profilaktik dozda, bir folik asit antagonisti olan Mix.
kullanılmıştır.

Keywords

Mol Hidatiform Trofoblastik Hastalıklar Koryokarsinoma

References

  • 1 — ACOSTA, B. E.: Mole Hydatifonn: Cometario a proposito de 168 observations. Mem. IV Cong. Mex. Ginec. Obstet. 2: 208, 1963.
  • 2 — ACOSTA -SISON, H.: Relationship of hydatiform mole to preeclamsia and eclampsia: A Study of 85 cases. Amer. J. Obstet. Gynec. 71 : 1279, 1956.
  • 3 — ACOSTA - SISON, H. : Diseases of the chorion : Hydatiform mole, Syneytloma, Chorioadenoma Destruens and Choriocarcinoma, Cited in Obstetrics (Greenhill), 13 Baskı, W.B. Saunders Comp. Philadelphia, 1965
  • 4 — CHUND, D., BRAGA, F. CHOW, C., LOK, L. : Clinical observations on some aspects of hydatiform mole. J, Obstet. Gynec. Brit. Cwlth. 71 : 180, 1964.
  • 5 — ÇANGA, Ş, ESANDAL, A., YAVUZ, H.: Over Tümörleri. Ders Kitabı, A.Ü. Basımevi, Sayı : 236, Ankara 1970.
  • 6 — DEREK, L. L. J.: Trophoblastic tumors: Geographical varlatlons in incidence and possiple ethiological factors. J. Obstet. Gynec. Brit. Cwlth.
  • 7 — DIVACK, M. M., JANOVSKY, N.A, : Hydatiform mole in women over 50 years of age. Obstet. Gynec. 19 : 76, 1962. 8-ENGLUND, S., ODEBTOD: Uterus.rupturer under greviditet och förlossring Vid tümörer, endometros och mola hydatidosa. Nord. med. 44:1992, 1950.
  • 9-EVANS, T. N., ZUIDEMA, G. D., ANDERSON, D. G,, BOOKSTEIN, J. J.: Metastatic chorioadenoma destruens with intestinal ohemorrhage. Obstet. Gynec. 26 : 570, 1965.
  • 10-GOLDSTEIN, D. P., REID, D. E.: Recent developments in the management of molar pregnancy. Clinical Obstet. and Gynec. Harper- Row Publ. 10:313. 1967.
  • 11-HAMMOND, C, B., PARKER, R. T.: Diagnosis and treatment of trophoblastic disease. Obstet. Gynec. 35: 133, 1970.
  • 12-HERTING, A. T., SHELDON, W. H.: Hydatiform Mole, A patologica - clinical correlatlon of 200 Cases. Amer. J, Obstet. Gynec, 58: 1, 1947.
  • 13-HERTZ, R., LEWİS, J. L., LEPSETT, M. B.: Five years experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer. J. Obstet. Gynec. 82: 621, 1961.
  • 14-HERTZ, R., ROSS, T., LIPSETT, M.B. : Primary chemotherapy of non-metastatlo trophoblastic disease in women, Amer. J. Obstet. Gynec. 86 : 808, 1963.
  • 15-HOBSON, B. M.: Further observations on the excretlon of chorlonic gonadotropin by women with hydatiform mole. J. Omstet. Gynec. Brit, Emp. 65: 253, 1958.
  • 16-LAMBERT, B., BRUX, J.: Thecalutein cysts of pregnancy without mole or chorlonepithelloma. Report of 2 cases. Obstet, Gynec, 22 : 43, 1963.
  • 17-LEE, A. T., SIRGEL, TI. : Hydatifarm mole with rupture oh the uterus. Report of a case, Obstet, Gynec. 26: 133, 1965.
  • 18-LEWİS, J,, JR, GORE, H., HERTİĞ, A. T.,, GOSE, D. A,: Treatment of trop hoblastic disease, with rationale for the use of adjunctive chemotherepy at the time of indicated operatlon, Amer. J. Obstet. Gynec. 96: 710, 1966.
  • 19-LI, M. C,, Hertz, R., SPENCER, D, B. : Effect of methotrexate therapy upon chorlocarcinoma and chorioadenoma, Prec. Soc. Exp. Biol. (N, Y.) 93: 361, 1956.
  • 20-MACGREGOR, C., ANTIVEROS, E., VARGAS, E, VATENZULLA, S.: Hydatiform mole. Analysis of 145 patlents. Obstet. Gynec, 33 : 343, 1969.
  • 21-MARCHAND, F.: Uber du sogen Annten «decidualen» geschwulste in Auschluss and normale Geburt, Abort, Blasenmole und extreuterin -scehwangerschaft. Msch. Geburtsh, Gynâk. 1:419, 1895.
  • 22-MARÇUEZ, M. H. ALFARO DE LE VAGA, G,, ROBLES, M. BOLİOCICERO, A. : Epidemiology and Pathology of hydatiform molen in the general hospital of Mexico : Study of 105 cases. Amer. JI. Osbtet. Gynec. 856 : 856, 1965.
  • 23-MAUDSLEY, R. F., ROBERTSON, E. M. : Hydatiform mole ina women over 52 years old, Obstet. Gynec. 26: 542, 1965.
  • 24-NOVAK, E.R., WOODRUFF, J. D.: Gynecology and Obstetrical Patolog'y. 5. Baskı, W.B. Saunders Comp. Philadelphia, 1962.
  • 25-ROSE, G, T. HAMMOND, C. B., W. D.: Chemotherapy for nonmetas. tatic gestational trophoblastic neoplasm. Clinical Obstetrics and Gynecology. 10: 323, 1967.
  • 26-STANDERS, R. W.: Abnormalities of placenta, membranes and fetus. Texbook of Obstet. and Gynecology (D. N. Danforth). Harper- Row Publ. New York, 1966.
  • 27-STANDERS, R. W.: Diseases of the trophoblast. Cited in Textbooks of Obstet, and Gynecology (D. N. Danforth), Harper - Row Pubi. New York, 1966.
  • 28-SANGER, M.: Zwei Aussergewohn Liche Falle Von Abortus. Zbi. Gynâk. 18: 132, 188.
  • 29-SMALBRAAK, K. L.: Trophoblastic growths. EBlsevier, Amsterdam, 1947.
  • 30-TAYLOR, E., DROGEMULLER, W. : Ghoriocarcinoma, choriocdenoma destruens, and syeytial endometritis. Amer. J. Obstet. Gynec. 83: 958, 1962.
  • 31-TEACHER, J. H. : Chorlonepithelioma. J. Obstet. Gynec. Brit. Cwlth. A: 145, 1963.

BENIGN TROPHOBLASTIC DISEASES Analysis of 30 Cases

Year 1972, Volume: 25 Issue: 3, 473 - 489, 30.09.1972

Hikmet Yavuz

Abstract

An survey is made of 28 hydatiform molar pregnancies and 2chorioadenoma destruens among a total 15232 pregnancies. The metods which we have used for the diagnosis, treatment of molar pregnancies described in detail, The results taken in our clinic are pointed also. Because of this benign trophoblastik disease plays a role in the ethiology of choriocarcinoma, it is very important to use methotraxate after the treatment of mole hydaiform for he prophylaxy of choriocarcinoma. By the using of prophylactic chemotherapy in benign trophoblastic diseases not only morbidity of molar pregnancy but also the time necessary for follow-up could be minimized.

Keywords

Hydatidiform Mole Trophoblastic Disease Choriocarcinoma

References

  • 1 — ACOSTA, B. E.: Mole Hydatifonn: Cometario a proposito de 168 observations. Mem. IV Cong. Mex. Ginec. Obstet. 2: 208, 1963.
  • 2 — ACOSTA -SISON, H.: Relationship of hydatiform mole to preeclamsia and eclampsia: A Study of 85 cases. Amer. J. Obstet. Gynec. 71 : 1279, 1956.
  • 3 — ACOSTA - SISON, H. : Diseases of the chorion : Hydatiform mole, Syneytloma, Chorioadenoma Destruens and Choriocarcinoma, Cited in Obstetrics (Greenhill), 13 Baskı, W.B. Saunders Comp. Philadelphia, 1965
  • 4 — CHUND, D., BRAGA, F. CHOW, C., LOK, L. : Clinical observations on some aspects of hydatiform mole. J, Obstet. Gynec. Brit. Cwlth. 71 : 180, 1964.
  • 5 — ÇANGA, Ş, ESANDAL, A., YAVUZ, H.: Over Tümörleri. Ders Kitabı, A.Ü. Basımevi, Sayı : 236, Ankara 1970.
  • 6 — DEREK, L. L. J.: Trophoblastic tumors: Geographical varlatlons in incidence and possiple ethiological factors. J. Obstet. Gynec. Brit. Cwlth.
  • 7 — DIVACK, M. M., JANOVSKY, N.A, : Hydatiform mole in women over 50 years of age. Obstet. Gynec. 19 : 76, 1962. 8-ENGLUND, S., ODEBTOD: Uterus.rupturer under greviditet och förlossring Vid tümörer, endometros och mola hydatidosa. Nord. med. 44:1992, 1950.
  • 9-EVANS, T. N., ZUIDEMA, G. D., ANDERSON, D. G,, BOOKSTEIN, J. J.: Metastatic chorioadenoma destruens with intestinal ohemorrhage. Obstet. Gynec. 26 : 570, 1965.
  • 10-GOLDSTEIN, D. P., REID, D. E.: Recent developments in the management of molar pregnancy. Clinical Obstet. and Gynec. Harper- Row Publ. 10:313. 1967.
  • 11-HAMMOND, C, B., PARKER, R. T.: Diagnosis and treatment of trophoblastic disease. Obstet. Gynec. 35: 133, 1970.
  • 12-HERTING, A. T., SHELDON, W. H.: Hydatiform Mole, A patologica - clinical correlatlon of 200 Cases. Amer. J, Obstet. Gynec, 58: 1, 1947.
  • 13-HERTZ, R., LEWİS, J. L., LEPSETT, M. B.: Five years experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer. J. Obstet. Gynec. 82: 621, 1961.
  • 14-HERTZ, R., ROSS, T., LIPSETT, M.B. : Primary chemotherapy of non-metastatlo trophoblastic disease in women, Amer. J. Obstet. Gynec. 86 : 808, 1963.
  • 15-HOBSON, B. M.: Further observations on the excretlon of chorlonic gonadotropin by women with hydatiform mole. J. Omstet. Gynec. Brit, Emp. 65: 253, 1958.
  • 16-LAMBERT, B., BRUX, J.: Thecalutein cysts of pregnancy without mole or chorlonepithelloma. Report of 2 cases. Obstet, Gynec, 22 : 43, 1963.
  • 17-LEE, A. T., SIRGEL, TI. : Hydatifarm mole with rupture oh the uterus. Report of a case, Obstet, Gynec. 26: 133, 1965.
  • 18-LEWİS, J,, JR, GORE, H., HERTİĞ, A. T.,, GOSE, D. A,: Treatment of trop hoblastic disease, with rationale for the use of adjunctive chemotherepy at the time of indicated operatlon, Amer. J. Obstet. Gynec. 96: 710, 1966.
  • 19-LI, M. C,, Hertz, R., SPENCER, D, B. : Effect of methotrexate therapy upon chorlocarcinoma and chorioadenoma, Prec. Soc. Exp. Biol. (N, Y.) 93: 361, 1956.
  • 20-MACGREGOR, C., ANTIVEROS, E., VARGAS, E, VATENZULLA, S.: Hydatiform mole. Analysis of 145 patlents. Obstet. Gynec, 33 : 343, 1969.
  • 21-MARCHAND, F.: Uber du sogen Annten «decidualen» geschwulste in Auschluss and normale Geburt, Abort, Blasenmole und extreuterin -scehwangerschaft. Msch. Geburtsh, Gynâk. 1:419, 1895.
  • 22-MARÇUEZ, M. H. ALFARO DE LE VAGA, G,, ROBLES, M. BOLİOCICERO, A. : Epidemiology and Pathology of hydatiform molen in the general hospital of Mexico : Study of 105 cases. Amer. JI. Osbtet. Gynec. 856 : 856, 1965.
  • 23-MAUDSLEY, R. F., ROBERTSON, E. M. : Hydatiform mole ina women over 52 years old, Obstet. Gynec. 26: 542, 1965.
  • 24-NOVAK, E.R., WOODRUFF, J. D.: Gynecology and Obstetrical Patolog'y. 5. Baskı, W.B. Saunders Comp. Philadelphia, 1962.
  • 25-ROSE, G, T. HAMMOND, C. B., W. D.: Chemotherapy for nonmetas. tatic gestational trophoblastic neoplasm. Clinical Obstetrics and Gynecology. 10: 323, 1967.
  • 26-STANDERS, R. W.: Abnormalities of placenta, membranes and fetus. Texbook of Obstet. and Gynecology (D. N. Danforth). Harper- Row Publ. New York, 1966.
  • 27-STANDERS, R. W.: Diseases of the trophoblast. Cited in Textbooks of Obstet, and Gynecology (D. N. Danforth), Harper - Row Pubi. New York, 1966.
  • 28-SANGER, M.: Zwei Aussergewohn Liche Falle Von Abortus. Zbi. Gynâk. 18: 132, 188.
  • 29-SMALBRAAK, K. L.: Trophoblastic growths. EBlsevier, Amsterdam, 1947.
  • 30-TAYLOR, E., DROGEMULLER, W. : Ghoriocarcinoma, choriocdenoma destruens, and syeytial endometritis. Amer. J. Obstet. Gynec. 83: 958, 1962.
  • 31-TEACHER, J. H. : Chorlonepithelioma. J. Obstet. Gynec. Brit. Cwlth. A: 145, 1963.
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Obstetrics and Gynaecology
Journal Section Articles
Authors

Hikmet Yavuz This is me

Publication Date September 30, 1972
Published in Issue Year 1972 Volume: 25 Issue: 3

Cite

APA Yavuz, H. (1972). Benign Trofoblastik Hastalıklar 30 Vakanın Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 25(3), 473-489.
AMA Yavuz H. Benign Trofoblastik Hastalıklar 30 Vakanın Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. September 1972;25(3):473-489.
Chicago Yavuz, Hikmet. “Benign Trofoblastik Hastalıklar 30 Vakanın Analizi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 25, no. 3 (September 1972): 473-89.
EndNote Yavuz H (September 1, 1972) Benign Trofoblastik Hastalıklar 30 Vakanın Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 25 3 473–489.
IEEE H. Yavuz, “Benign Trofoblastik Hastalıklar 30 Vakanın Analizi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 25, no. 3, pp. 473–489, 1972.
ISNAD Yavuz, Hikmet. “Benign Trofoblastik Hastalıklar 30 Vakanın Analizi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 25/3 (September 1972), 473-489.
JAMA Yavuz H. Benign Trofoblastik Hastalıklar 30 Vakanın Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1972;25:473–489.
MLA Yavuz, Hikmet. “Benign Trofoblastik Hastalıklar 30 Vakanın Analizi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 25, no. 3, 1972, pp. 473-89.
Vancouver Yavuz H. Benign Trofoblastik Hastalıklar 30 Vakanın Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1972;25(3):473-89.