Two Sympathomimetic Amines Used by Inhalation in Bronchial Asthma (A Comparative Study on the Clinical and Cardio-Respiratory Physiological Effects of Isoprenaline Sulfate and Orciprenaline Sulfate)
Abstract
Two sympathomimetic amines, orciprenaline sulfate and isoprenaline sulfate, administered by aerosol in the treatment of acute attacks of bronchial asthma, were studied and compared in 26 cases. Their early (5-10 minutes) and late (2 hours) effects on clinical and cardiorespiratory functions were investigated and compared. Both drugs were found to produce pronounced bronchial dilation starting 5 minutes after inhalation, and this effect, although slightly diminished, persisted for 7 hours. Orciprenaline had a slightly greater bronchodilator effect than Isoprenaline.
Orciprenaline caused an increase in systolic blood pressure of 46.8.7 mmHg, starting immediately after inhalation in 26 cases, while Isoprenaline caused a more rapid decrease in systolic blood pressure. (96 10 mmHg.)
Both sympathomimetic amines were found to cause tachycardia, which began early and lasted for up to 2 hours, and the tachycardiac effect was significantly greater with isoprenaline (224 increase in SHO in the first 5-10 minutes).
Literature review was conducted on drug selection, administration, and side and toxic effects in the treatment of acute attacks of bronchial asthma and compared with the results obtained in the study.
Keywords
References
- 1 — KENNEDY M, JACKSON L.: Oral Synpathomimetic Amines in Treatment of Astma : Brit. Med. J., 1506, 14, 1963 '
- 2 —- FREEDMANN B, and all : Bronchodilatois and Corticosteroids in Chronic Bronchitis and Emphysema : Brit, Med, J,, 14, 1509, 1963
- 3 — FREEDMANN B. MEİSNER P, HILL G, B.; A Comparison of the Actions of Different Bronchodilators in Astma : Thorax, 28, 590, 1968
- 4 -- SANNDERS K. B.: Broshodilator Responses Patterns in Patients with Chronic Air-way Obstructions : Brit, Med. J,, 2, 399, 1067
- 5- i CROMPTON G, K.: A Comparison of Responses to Bronchodilator Drugs in Chronic Bronchitis and Chronic Astma : Thorax : 23, 46, 1966
- 6 -—- RIDING W. D., PINDA P., CHATTEJEE 5S, S,: The Bronchodilators and Cardiac Effects of five Presure-Packet Aerosol in Asthma : Brit, J. Dis. Chest, 1, 387, 1970
- 7 — CHAPMANN T, T, HUGHER D. T.: Hypoxia in Bronchial Asthma : Brii, Med. J, 2, 639, 1967
- 8 - WADDELL IJ, A, EMERSON P, A, GUNSTONE R. F.: Hypoxia in Bronchial Asthma Brit, Med, J,, 2, 402, 1967
- 9 — KERR J, W.: Deaths Form Asthma : Brit, Med. TI, 2, 177, 1967
Bronş Astımında İnhalasyon Yolu ile Kullanılan İki Sempatomimetik Amin (Isoprenaline sulphate ve orciprenaline sulphate’ın klinik ve kardiyo-respiratuar fizyolojik etkileri üzerinde karşılaştırılmalı bir araştırma)
Abstract
Bronş astımının akut nöbet tedavisinde aerosol yolla kullanılan iki sempatomimetik amin-orciprenaline sulphate ve isoprenaline sulphate - 26 vak'a üzerinde kullanıldı. Uygulamadan sonra erken (5-10 Dak.) ve geç (2 saat sonra) klinik ve kardio- respiratuar fonksiyonlar üzerindeki etkileri araştırıldı ve karşılaştırıldı. Her iki ilâ- cında, inhalasyondan sonra 5 dakikadan itibaren aşikâr bronş dila- tasyonu meydana getirdiği bu tesirin hafifçe azalmakla beraber ? saat devam ettiği ve Orciprenaline'de Isoprenaline nazaran biraz da- ha fazla bronkodilatatör etki bulunduğu tesbit edildi.
Orciprenalinde 26 vak'ada hemen inhalasyondan sonra başlayan
ortalama 46 8.7 mmHg. basıncı kadar bir sistolik kan basıncı yüksel- mesi, Isoprenalinde ise aksine ani bir sistolik kan basıncı düşüklüğü
görüldü. (96 10 mmHg.)
Her iki sempatomimetik amininde, erken başlayan ve 2 saat kadar devam eden taşikardiye sebep olduğu ve taşikardiak etkinin Isoprenalinde belirli bir şekilde daha fazla bulunduğu görüldü. (ilk
5-10 Dak. da Şo 224 artma).
Bronş astımının akut nöbet tedavisinde ilâç seçimi, kullanma
şekli ve yan ve toksik etkileri üzerinde literatür bilgisi gözden geçirilerek, çalışmadan çıkarılan sonuçlarla karşılaştırıldı.
Keywords
References
- 1 — KENNEDY M, JACKSON L.: Oral Synpathomimetic Amines in Treatment of Astma : Brit. Med. J., 1506, 14, 1963 '
- 2 —- FREEDMANN B, and all : Bronchodilatois and Corticosteroids in Chronic Bronchitis and Emphysema : Brit, Med, J,, 14, 1509, 1963
- 3 — FREEDMANN B. MEİSNER P, HILL G, B.; A Comparison of the Actions of Different Bronchodilators in Astma : Thorax, 28, 590, 1968
- 4 -- SANNDERS K. B.: Broshodilator Responses Patterns in Patients with Chronic Air-way Obstructions : Brit, Med. J,, 2, 399, 1067
- 5- i CROMPTON G, K.: A Comparison of Responses to Bronchodilator Drugs in Chronic Bronchitis and Chronic Astma : Thorax : 23, 46, 1966
- 6 -—- RIDING W. D., PINDA P., CHATTEJEE 5S, S,: The Bronchodilators and Cardiac Effects of five Presure-Packet Aerosol in Asthma : Brit, J. Dis. Chest, 1, 387, 1970
- 7 — CHAPMANN T, T, HUGHER D. T.: Hypoxia in Bronchial Asthma : Brii, Med. J, 2, 639, 1967
- 8 - WADDELL IJ, A, EMERSON P, A, GUNSTONE R. F.: Hypoxia in Bronchial Asthma Brit, Med, J,, 2, 402, 1967
- 9 — KERR J, W.: Deaths Form Asthma : Brit, Med. TI, 2, 177, 1967
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Thoracic Surgery |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 30, 1973 |
| Published in Issue | Year 1973 Volume: 26 Issue: 3 |