Otoimmün Tiroid Hastalıkları ve Sekonder Otoimmün Reaksiyonların Müşahede Edildiği Tiroid Rahatsızlıkları: 1 — TİROİDİTLER VE HİPOTİROİDİZM

Year 1973, Volume: 26 Issue: 3, 715 - 736, 30.06.1973

Selahattin Koloğlu

Abstract

A. Ü. Tıp Fakültesi İç Hastalıkları Kliniği Endokrinoloji ve Metabolizma bölümünde yapılan çalışmada, 3 Hashimoto hastalığı, 61 subakut tiroidit vakası ve 22 primer hipotiroidizm vakasında tiroid antikorları ayrıntılı bir şekilde incelenmiştir. Hashimoto hastalığı ve primer erişkin miksödeminde tiroid otoantikorlarının yüksek seviyeleri teyit edilmiş ve bu iki tiroid hastalığının oluş mekanizmalarında otoimmün reaksiyonların rolü tartışılmıştır. Ayrıca, bu yazıda post-radioizotopik hipotiroidizm ile otoimmün reaksiyonlar arasındaki ilişki gözden geçirilmiş ve subakut tiroiditlerde tespit edilen tiroid otoantikorlarının hastalığın seyri sırasında sekonder olarak ortaya çıktığı belirtilmiştir.

Keywords

Tiroid Otoantikorları , Hashimoto Hastalığı , Subakut Tiroidit

Autoimmune Thyroid Diseases and Thyroid Disorders in Which Secondary Autoimmune Reactions Are Observed: 1 — THYROIDITIS AND HYPOTHYROIDISM

Abstract

In a study conducted in the Endocrinology and Metabolism Department of the Internal Medicine Clinic at A. Ü. Faculty of Medicine, thyroid antibodies were examined in detail in 3 cases of Hashimoto's disease, 61 cases of subacute thyroiditis, and 22 cases of primary hypothyroidism. Elevated levels of thyroid autoantibodies were confirmed in Hashimoto's disease and primary adult myxedema, and the role of autoimmune reactions in the mechanisms of these two thyroid diseases was discussed. Additionally, this paper reviewed the relationship between post-radioisotopic hypothyroidism and autoimmune reactions, and it was noted that thyroid autoantibodies detected in subacute thyroiditis appeared secondarily during the course of the disease.

Keywords

Thyroid Autoantibodies , Hashimoto , Subacute Thyroiditis

References

• 1 — BELING, U., et al.: Post-radioisotopic hypothyroidism, Acta Radiol (Stockholm), 56: 275, 1961.
• 2 — BLAGG, C.R.: Antithyroid antibodies after I-131 treatment, Lancet, 2; 1364, 1960.
• 3 — BOYDEN, S.V.: The erythrocytes treated with tannic acid anti-protein sera, J. Exp. Med., 93: 107, 1951.
• 4 — BUCHANAN, W.W., et al.: Skin test in thyroid disease, Lancet, 2: 928, 1958.
• 5 — BUCHANAN, W.W., et al.: Thyroid autoantibodies following I-131 treatment, J. Endocr., 24: 115, 1962.
• 6 — CASSIDY, C.E., MURPHY, S.S.: Post-radioiodine myxedema, Clinical Endocrinology (Ed. Astwood, Cassidy), 11: 253, 1968.
• 7 — CİCİOĞLU, R., PAYZIN, S., ÖKTEM, K.: Tiroid hastalığı belirtileri gösteren ve normal bireylerde antitiroid antikorların durumu. I. Dolaşım oto-antikorların durumu, Tiroid Bezi ve Hastalıkları Simpozyumu, Diyarbakır Tıp Fak., 1971, sayfa: 54.
• 8 — CSIZMAS, L.: Preparation of formalinized erythrocytes, Proc. Soc. Exp. Biol. (NY) 103: 1957, 1960.
• 9 — DeGROOT, L.J., et al.: Hashimoto's thyroiditis: a genetically conditioned case, New Eng. J. Med., 267: 267, 1962.
• 10 — DONIACH, D., ROITT, I.M.: Autoimmunity in Hashimoto's disease and its implications, J. Clin. Endocr., 17: 1923, 1957.
• 11 — DONIACH, D., ROITT, I.M.: Clinical applications of thyroid autoantibody tests, In Clinical Aspects of Immunology, pp: 612, 1963.
• 12 — DONIACH, D., et al.: Auto-immune phenomena in pernicious anemia: Serological overlap with thyroiditis, thyrotoxicosis, and systemic lupus erythematosus, Brit. Med. J., 1: 1374, 1963.
• 13 — DUNN, J.J., CHAPMAN, E.M.: Post-radioisotopic hypothyroidism, New Eng. J. Med., 271: 1037, 1964.
• 14 — EINHORN, J., et al.: Autoantibodies after I-131 treatment, Clin. Endocr., 25/9: 1218, 1965.
• 15 — EINHORN, J.: Hypothyroidism following I-131 treatment for hyperthyroidism, J. Clin. Endocr. Met., 26/1: 33, 1966.
• 16 — EYLAN, E., ZMUCKY, R.: Mumps virus and subacute thyroiditis, Lancet, 1062: 6978, 1957.
• 17 — FIALKOW, P.J., et al.: Increased frequency of thyroid autoantibodies in mothers of patients with Down's syndrome, Lancet, 2: 868, 1965.
• 18 — FREEMAN, M., et al.: Post-radioisotopic thyroiditis, New York J. Med., 69: 2036, 1969 (in Year Book of Endocr., 1970/151).
• 19 — FÜLTHORPE, A.J., ROITT, I.M., DONIACH, D.: Thyroid hemagglutination test, J. Clin. Path., 14: 654, 1961.
• 20 — GOLDSMITH, R., McADAMS, A.J., LARSEN, P.R.: Familial autoimmune thyroiditis: Maternal-fetal relationship and the role of generalized autoimmunity, J. Clin. Endocr. Met., 37/2: 265, 1978.
• 21 — GREEN, N.M., WILSON, C.M.: Hypothyroidism after I-131 treatment, Brit. Med. J., 1: 1005, 1964.
• 22 — HALL, R., et al.: Paternal transmission of thyroid autoimmunity, Lancet, 2: 115, 1964.
• 23 — HALL, R., STANBURY, J.B.: Hashimoto disease, Clin. Exp. Immunol., 2: T19, 1967.
• 24 — HALL, R., et al.: Study of the parents of patients with Hashimoto disease, Lancet, 2: 1291, 1962.
• 25 — HASSAN, T.H.A., et al.: Toxic diffuse goiter in monozygotic twins, Lancet, 2: 806, 1966.
• 26 — HJORT, T., MOGENSEN, B.F.: Post-thyroidectomic hypothyroidism, Acta Med. Scan., 171: 289, 1962.
• 27 — HOFFMAN, E.: Hashimoto's thyroiditis, Arch. Surg., 92: 865, 1966.
• 28 — IRVINE, W.J., et al.: Post-radioisotopic myxedema, Lancet, 2: 843, 1962.
• 29 — IRVINE, W.J.: Hashimoto disease, Quart. J. Exp. Physiol., 49: 324, 1969.
• 30 — KRISS, J.P., et al.: Studies on the pathogenesis of the ophthalmopathy of Graves' disease, J. Clin. Endocr., 27: 582, 1967.
• 31 — MAENPAA, J.: Hashimoto disease, Acta Pediatr. Scand., 61: 49, 1972.
• 32 — MAHIEU, P., WINAND, R.: Demonstration of delayed hypersensitivity to retrobulbar and thyroid tissues in human exophthalmos, Abstracts, IV. Intern. Cong. of Endocr., Washington 1972.
• 33 — MORI, T., KRISS, J.P.: Measurements by competitive binding radioassay of serum anti-microsomal and anti-thyroglobulin antibodies in Graves' disease, J. Clin. End. and Met., 33/4: 688, 1971.
• 34 — NAKAMURA, R.M., WEIGLE, W.O.: Antibody transfer, J. Exp. Med., 130: 268, 1969.
• 35 — O'GORMAN, P., et al.: Anti-T and Anti-M autoantibodies, J. Clin. Endocr., 24: 1072, 1964.
• 36 — OUCHTERLONY, O.: Handbook of Immunodiffusions and Immunoelectrophoresis, Ann Arbor-Humphrey Science Publishers, 1971.
• 37 — PAINE, J.R.: Hashimoto disease, Surgery, 42: 799, 1957.
• 38 — PARKER, R.H., BEIERWALTES, W.H.: Thyroid antibodies during pregnancy and in newborn, J. Clin. Endocr., 21: 792, 1961.
• 39 — PINCHERA, A., et al.: Thyrotropin and LATS assays in thyroid disease, J. Clin. End., 25: 189, 1965.
• 40 — PINCHERA, A., et al.: Antithyroid antibodies, J. Clin. Endocr., 27/12: 1758, 1967.
• 41 — ROITT, I.M., CAMPBELL, P.N.: The nature of the thyroid autoantibodies present in patients with Hashimoto's thyroiditis, Biochem. J., 69: 248, 1958.
• 42 — ROITT, I.M., DONIACH, D.: Human autoimmune thyroiditis serological studies, Lancet, II: 1027, 1958.
• 43 — ROSENBERG, I.N.: Thyroiditis and thyroid antibodies, Clin. Endocr., Grune and Stratton (Astwood), New York, 1960.
• 44 — SCHEIDEGGER, J.J.: Une microméthode de l'immunoélectrophorèse, Int. Arch. Allergy, 1108: 110, 1955.
• 45 — SKANSE, B., NILSON, S.B.: Antithyroid antibodies, Acta Med. Scand., 171: 289, 1962.
• 46 — STAVITSKY, A.B.: Micromethods for the study of proteins and antibodies, J. Immunol., 72: 360, 1954.
• 47 — VOLPE, K., et al.: Circulating viral and antithyroid antibodies in subacute thyroiditis, Proceedings, American Thyroid Association, pp: 48, 1966.
• 48 — VOLPE, R., et al.: Thyroid antibodies, Amer. J. Med., 46: 217, 1969.
• 49 — WITEBSKY, E., ROSE, N.R.: Production of rabbit thyroid antibodies in the rabbit, J. Immunol., 76: 408, 1956.
• 50 — WITEBSKY, E.: Chronic thyroiditis and autoimmunization, J. Amer. Med. Ass., 164/13: 1439, 1957.
• 51 — WITEBSKY, E., ROSE, N.R.: The autoantibody nature of the thyroiditis antibody, Lancet, 7025: 808, 1958.