Genetik ve Diabetes Mellitus

Year 1973, Volume: 26 Issue: 3, 817 - 840, 30.06.1973

Bekir Sıtkı Şaylı

Abstract

Diabetes mellitus is one of disorders of carbohydrate metabolism, according to several authors, present at the time of conception of the individual. in fact, there are several lines of evidence indicating that the heredity plays an important role in the genesis of the disease. These are given as familial aggregation, monozygotic twin concordance, pedigree patterns and animal models. The associated syndro mes, population studies and different pathological investigations also support this view of hereditary basis.
Despite these observations and some but limited experiments, the mode of transmission has not been yet established and it seems impossible at the present stage of our knowledge to decide which of the different kinds of transmission is involved. This, of course, is due to difficulties of ascertainement and that the basic defect, whether central or peripheral, macroscopic or microscopic, molecular or enzymatic, is almost completely unknown.

Keywords

Diabetes Mellitus , Genetics , Prevalence

Genetics and Diabetes Mellitus

Abstract

Genetik diabetes mellitusdan söz edilmesine ve bu anlayışın haklılığının çeşitli metodlarla desteklenmesine rağmen, hastalığın kalıtım yolu bilinmemektedir. öte yandan, kondisyona yol açan temel kusur açık değildir. O nedenle ileri sürülen çeşitli hipotezler ve teklif olunan santral veya periferik, makroskopik veya moleküler modeller henüz tartışmasız kabul edilememektedir.

Keywords

Diabetes Mellitus , Genetik , Prevalans

References

• 1— Postgraduate Med., Editorial. 43 : 1968.
• 2— A TABER, E. : Kapadokyall Aretaeus (Aretaeus de Cappodoce). Gelikcilt Matbaası, Istanbul, 1973.
• 3— RiMOtN, D. L. : Genetics of diabetes mellitus. Diabetes, 16 : 346, 1967 tarafından zikredildiği üzere.
• 4— Diabetes Mellitus. Wrid. Hith. org. tech. Rep. ser., No. 310, 1965.
• 5— NEEL, J. V., SHAW, M., SCHULL W. : Genetics and Epidemiology of Chronic Diseases. U. S. Dept. Health Education and Welfare, Public Health Service, 1965.
• 6— FAJANS, S. S., CONN, J. W. : Prediabetes, subclinical diabetes and latent diabetes: Interpretation, diagnosis and treatment. On the Nature and Treatment of Diabetes'de, Yayınlayan: Leibel B. S., Wrenshall, G. S., New York, Excerpta Medica Foundation, International Congress series, 84 : 641 - 656, 1965.
• 7— PINCUS, G., WHITF, P. : On the inheritance of diabetes: 1. Analysis of 675 family histories. Amer. J. Med. Sci., 186 : 1, 1933.
• 8— RÏMOIN, D. L. : Inheritance in diabetes mellitus. Symposium on Diabetes Mellitus'da. Med. Clin North America, 55 : 807 - 819, 1971.
• 9— BRAUNSTEINER, H., HANSEN, W., JUNG, A., SEILER, S. : Latent diabetes in the parents of juvenile diabetics. German Med. Monthly, 1.1 227, 1966.
• 10— JOSLIN, E. P., ROOT, H. F., WHITE, P., MARBLE A. : The treatment of diabetes mellitus. Lea and Febiger. 10. Baskı, Philadelphia, 1959.
• 11— HANHART E. : Zur Vererbung des Diabetes mellitus. Schweiz Med. Wchschr., 81 : 1127, 1951.
• 12— CONN, J. W., FAJANS, S. S. : The prediabetic stage. Amer. J. Med., 31 : 839, 1961.
• 13— NEEL, J. V. : The genetics of diabetes mellitus. Adv. Metab. Dis., 1 (Suppl.) : 3, 1970.
• 14— FALCONER, D. S. : The inheritance of liability to disease with variable age of onset with particular reference to diabetes mellitus. Ann. Hum. Genet. (Lond.), 31 : 1, 1967.
• 15— SIMPSON, N. : Heritabilities of liability to diabetes when sex and age of onset are considered. Ann. Hum. Genet. (Lond.), 32 : 283, 1969.
• 16— STEINER, F. : Untersuchungen zur Frage der Erblichkeit des Diabetes mellitus. Dtsch. Arch. Klin. Med., 118 : 497, 1963.
• 17— THEN BERG H. : The genetic aspect of diabetes mellitus. JAMA (foreign letters, German), 112 : 1091, 1939.
• 18— CERASt, LUFT, R. : Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs: Genetic control of insulin response. Acta Endocrinol., 55 : 330, 1967.
• 19— D. A. CASSAR, J., TODD, J., TAYLOR, K. W.: Glucose tolerance test and serum insulin in identical twins of diabetics. Brit. Med. J., iv : 649, 1970.
• 20— NILSSON, S. E. : On the heredity of diabetes mellitus and its interrelationship with some other diseases. Acta Genetica, 14 : 97, 1964.
• 21— STEINBERG, A. G. : Genetics and Diabetes. On the Nature and Treatment of Diabetes'de. Excerpta Medica International Congress Series, 88 : 601, 1965.
• 22— BARRAT L., CANN, H. M. : Segregation analysis of juvenile diabetes mellitus. J. Med. Genet., 2 : 8, 1965.
• 23— POST, R. H. : An approach to the question, Does all diabetes depend on a single genetic locus? Amer. J. Human Genet., 11 : 1962.
• 24— SIMPSON, N. E. : Multifactorial inheritance. A possible hypothesis for diabetes. Diabetes, 13 : 462, 1964.
• 25— NAVARETTE V. N., TORRES, I. H. : Triamcinolone provocative test in offspring of two diabetic parents. Diabetes, 16 : 57, 1967.
• 26— KAHN, C. B., SOELDNER, J. S., GLEASON, N., ROJAS L., CAME, RINT-DAVALOS, R. A., MARBLE A. : Clinical and chemical diabetes in offspring of diabetic couples. New Eng. J. Med., 281 : 343, 1969.
• 27— WALLANCE, OWEN, J. : Synalbumin in insulin antagonism. Diabetes, 19 : 241, 1964.
• 28— MIMURA, G., MIYAO, S. : Heredity and constitution of diabetes mellitus. Bull. Res. Inst. Diathetic Med., Kumamoto University, 12 (Suppl.) : 1, 1962. (D. L. Rimoin tarafından zikredildiği üzere, 1971).
• 29— PAVEL, I., PTEPTEA R. : Etude sur le diabète hereditare au cours de 3 et 4 générations successives. Diabetologia, 2 : 281, 1966.
• 30— On the mode of transmission of hereditary diabetes. Diabetologia, 4 : 358, 1968.
• 31— GEDDA, L., CASA, D., BRENC, G. : Chronon and the problem of anticipation (on two family cases of diabetes): Acta Genet. Medic. Gemellol., 16 : 217, 1967.
• 32— LEVIT, S., PESSTKOVA, L. N. : The genetics of diabetes mellitus. Proc. Maxim Gorky Medico. Biol. Inst. (Moscow), 3 : 132 - 47, 1934. (D. L. Rimoin tarafından zikredildiği üzere, 1967).
• 33— O. : Zur Genetik von Diabetes mellitus und renalem Diabetes. Med. Klin. 56 : 835, 1961.
• 34— LAWRENCE, R. D. : Three types of human diabetes. Ann. Int. Med., 48 : 1199, 1955.
• 35— PENROSE, L. S., WATSON, E. : A sex-linked tendency in familial diabetes. Proc. Amer. Diabetes Assoc., 5 : 165, 1945.
• 36— GRONBERG, A., LARSSON, T., JUNG, J. : Diabetes in Sweden. A clinical-statistical, epidemiological and genetic study of hospital patients and death certificates. Acta Med. Scandinav., 47 (Suppl.) : 126, 1967.
• 37— Cammidge, P. J. : Heredity as a factor in the aetiology of diabetes mellitus. Lancet, i : 393, 1934.
• 38— HARRIS, H. : The familial distribution of diabetes mellitus: A study of the relatives of 1241 diabetic propositi. Ann. Eugen., 15 : 95, 1950.
• 39— GEDDA, Ia., CASA, D., BRENC, G. : Chronon and the problem of anticipation. (On two family cases of diabetes). Acta Genet. Medic, Gemell., 16 : 217, 1967.
• 40— BURCH, P. R., A. : Early onset diabetes mellitus in the general and Down's syndrome populations. Lancet, i : 554, 1969.
• 41— LAMY, M., FREZAL, J., J. : Heredité du diabète sucré. J. Ann. Diabet. Hotel Dieu, 2 : 5, 1961.
• 42— GRUNNET, J. : Heredity in diabetes mellitus. A proband study. Opera ex Dome Biologiae Hereditariae Humanae Universitatis Hafniensis, 39 : 1 - 128, Copenhagen, Munksgaard, 1957 (J. Köbberling tarafından zikredildiği üzere, Studies on the genetic heterogeneity of diabetes mellitus. Diabetologia, : 46 -