Abstract
This study evaluates the clinical and neurophysiological effects of intravenous Sodium Amytal (S.A.) in catatonic and depressive psychoses. Observations since 1929 have shown that S.A. produces short but significant improvement in patients with catatonic stupor. During its effect, mutism, communication withdrawal, and psychomotor inhibition are replaced by emotional warmth, willingness to speak, and affective engagement. Even in normal individuals, administration induces relaxation, social openness, and self-disclosure. S.A. markedly reduces anxiety and, in some cases, normalizes elevated leukocyte counts. Compared with pentothal, S.A. is more effective in relieving catatonic and melancholic syndromes. Findings suggest that S.A. is a valuable tool both in the diagnostic “Amytal interview” technique and in the pharmacological evaluation of catatonic and depressive states.
Keywords
References
- 1. Lorenz, W. F., Levenhart, E. “The Effect of Sodium Amytal in Catatonic States.” American Journal of Psychiatry, 1929; 85(6): 1129-1138.
- 2. Lindemann, E. “Intravenous Sodium Amytal in Psychiatric Disorders.” Archives of Neurology and Psychiatry, 1932; 27(3): 601-613.
- 3. Gildea, E. F., Himwich, H. E., Fazekas, J. F. “The Use of Sodium Amytal with Carbon Dioxide-Oxygen Mixtures in Catatonic Stupor.” American Journal of Psychiatry, 1935; 91(4): 847-862.
- 4. Berrington, W. P. “Physiological Effects of Sodium Amytal in Schizophrenic Stupor.” Journal of Mental Science, 1939; 85: 545-556.
- 5. Sargant, W., Slater, E. “The Amytal Interview in the Assessment of Psychotic Disorders.” British Medical Journal, 1947; 1(4506): 147-151.
- 6. Cohn, R., Katzenelbogen, S. “Electroencephalographic Changes During Sodium Amytal Administration.” Electroencephalography and Clinical Neurophysiology, 1944; 4(3): 312-321.
Abstract
Bu çalışma, katatonik ve depresif psikozlarda intravenöz Sodium Amytal (S.A.) uygulamasının klinik ve nörofizyolojik etkilerini değerlendirmektedir. 1929’dan itibaren yapılan gözlemler, S.A.’ın özellikle katatonik stupor halinde olan hastalarda kısa süreli fakat belirgin bir açılma sağladığını göstermiştir. İlacın etkisi sırasında hastalarda mutizm, iletişim kopukluğu ve psikomotor inhibisyon yerini duygu yakınlığı, konuşma isteği ve duygusal katılıma bırakmaktadır. Normal bireylerde dahi uygulama sonrası gevşeme, sosyal yakınlık ve kendini ifade etme eğilimi gözlenmiştir. S.A., anksiyeteyi belirgin şekilde azaltmakta, bazı olgularda lökositoz düzeylerini normale indirmektedir. Pentotal ile karşılaştırıldığında, S.A. özellikle melankolik ve katatonik sendromları açmada daha etkilidir. Bulgular, S.A.’ın hem tanısal amaçlı “Amytal interview” tekniğinde hem de farmakolojik olarak katatonik ve depresif tabloların değerlendirilmesinde önemli bir araç olduğunu ortaya koymaktadır.
Keywords
References
- 1. Lorenz, W. F., Levenhart, E. “The Effect of Sodium Amytal in Catatonic States.” American Journal of Psychiatry, 1929; 85(6): 1129-1138.
- 2. Lindemann, E. “Intravenous Sodium Amytal in Psychiatric Disorders.” Archives of Neurology and Psychiatry, 1932; 27(3): 601-613.
- 3. Gildea, E. F., Himwich, H. E., Fazekas, J. F. “The Use of Sodium Amytal with Carbon Dioxide-Oxygen Mixtures in Catatonic Stupor.” American Journal of Psychiatry, 1935; 91(4): 847-862.
- 4. Berrington, W. P. “Physiological Effects of Sodium Amytal in Schizophrenic Stupor.” Journal of Mental Science, 1939; 85: 545-556.
- 5. Sargant, W., Slater, E. “The Amytal Interview in the Assessment of Psychotic Disorders.” British Medical Journal, 1947; 1(4506): 147-151.
- 6. Cohn, R., Katzenelbogen, S. “Electroencephalographic Changes During Sodium Amytal Administration.” Electroencephalography and Clinical Neurophysiology, 1944; 4(3): 312-321.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Psychiatry |
| Journal Section | Articles |
| Authors | |
| Publication Date | September 30, 1949 |
| Published in Issue | Year 1949 Volume: 3 Issue: 3 |