Biological Activities of Currant (Ribes sp.) and its Effects on Human Health

Abstract

Currants which have black, red and white color show high level antioxidant activity, because of containing phenols, flavone and flavonoids. These functional components that are active in protecting against many diseases have increased the important of currants especially in food industry. In recent years, black currant oil has been used as food supplements in the market. It has been proven in studies that the most common culture form of Ribes rubrum’s fruits, seeds, leaves and buds have antioxidants, anti-inflammatory, antiviral, anticancer, antidiabetic and antitumor activity. Just as fruits of Ribes rubrum have antibacterial, antiseptic, antiaging, cardio protective and anti-inflammatory effect, its leaves also have antioxidant effect. In addition, leaves and branches of Ribes species have antibacterial and antitumor activity. The results of several researches about the biological activity of currant and its effects on human health are given in this review.

Keywords

• Currant (Ribes sp.)
• antioxidant
• anticancer
• health

Frenk Üzümünün (Ribes sp.) Biyolojik Aktivitesi ve İnsan Sağlığı Üzerine Etkileri

Abstract

Kırmızı, siyah ve sarı renklere sahip olan frenküzümlerinin içerdikleri fenoller, flavon ve flavonoidler nedeniyle yüksek oranda antioksidan özellik gösterdiği bilinmektedir. Bu fonksiyonel bileşenlerin insan sağlığında birçok hastalığa karşı koruyucu role sahip olması frenküzümünün özellikle gıda sanayisindeki önemini arttırmıştır. Siyah frenküzümü yağının, son yıllarda gıda takviyesi olarak piyasalarda yer aldığı görülmektedir. En yaygın kültür formu olan Ribes nigrum’un yaprak, tomurcuk, meyve ve tohumlarının antioksidan, antienflamatuvar, antiviral, antidiyabetik, antikanser ve antitümör aktivitesi yapılan çalışmalarla kanıtlanmıştır. Meyveleri antibakteriyel, antiseptik, antiaging, cardioprotective ve antienflamatuvar etkiye sahip olan Ribes rubrum’un yapraklarının da antioksidan etkiye sahip olduğu bilinmektedir. Bununla birlikte Ribes türlerinin yaprak ve dallarının antibakteriyel ve antitümör etkisi de kanıtlanmıştır. Bu derlemede frenküzümünün biyolojik aktivitesi ve bu aktivitenin insan sağlığına kattığı faydalar hakkında bilgi verilmiştir.

Keywords

• Frenk üzümü (Ribes sp.)
• antioksidan
• antikanser
• sağlık

References

1. Aneta, W., O. Jan, M. Magdalena and W. Joanna, 2013. Phenolic Profile, Antioxidant and Antiproliferative Activity of Black and Red Currants (Ribes sp.) From Organic and Conventional Cultivation. International Journal of Food Science and Technology 48:715–726.
2. Bakowska–Barczak, A.M. and P.P. Kolodziejczyk, 2011. Black Currant Polyphenols: Their Storage Stability and Microencapsulation. Industrial Crops and Products 34:1301–1309.
3. Bakowska–Barczak, A.M., A. Schieber and P. Kolodziejczyk, 2009. Characterization of Canadian Black Currant (Ribes nigrum L.) Seed Oils and Residues. Journal of Agriculture Food Chemistry 57:11528–11536.
4. Baytop, T., 1999. Türkiye’de Bitkiler ile Tedavi. Geçmişte ve Bugün (İlaveli İkinci Baskı). Nobel Tip Kitabevleri, İstanbul. 208s.
5. Benvenuti, S., F. Pellati, M. Melegari and D. Bertelli, 2004. Polyphenols, Anthocyanins, Ascorbic Acid and Radical Scavenging Activity of Rubus, Ribes and Aronia. Journal of Food Science 69(3):164–169.
6. Cavanagh, M.A., M. Hipwell and J.M. Wilkinson, 2003. Antibacterial Activity of Berry Fruits Used for Culinary Purposes. Journal of Medicinal Food 6(1):57–62.
7. Cosmulescu, S., I. Trandafir and V. Nour, 2015. Mineral Composition of Fruit in Black and Red Currant South Western. Journal of Horticulture, Biology and Environment 6(1):43–51.
8. Çağlarırmak, N., 2006. Üzümsü Meyvelerin Polifenolik Bileşenlerin İnsan Sağlığı Yönünden Önemleri. 2. Ulusal Üzümsü Meyve Sempozyumu, 14–16 Eylül 2006. Tokat. 317–321

9. Çubukçu, B., A.H. Meriçli, A. Mat, G. Sarıyar, N. Sütlüpınar ve F. Meriçli, 2002. Fitoterapi Yardımcı Ders Kitabı. İstanbul Üniversitesi Eczacılık Fakültesi Farmakognazi Anabilim Dalı, İstanbul, 131s.
10. Djordjevic, D., K. Savikin, G. Zdunic, T. Jankovic, T. Vulic, C. Oparnica and D. Radivojevic, 2010. Biochemical Properties of Red Currant Varieties in Relation to Storage. Plant Foods Hum Nutr. 65:326–332.
11. Garbacki, N., M. Tits, L. Angenot and J. Damas, 2004. Inhibitory Effects of Proanthocyanidins from Ribes nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats. BMC Pharmacology 4(25):1–9.
12. Gençaslan, G., 2007. Türkiye’de Tıbbi Amaçla Kullanılan Bazı Bitkilerin Antioksidan Özelliklerinin Taranması (Yüksek Lisans Tezi). Ankara Üniversitesi Sağlık Bilimleri Enstitüsü Eczacılık ve Farmokoloji Anabilim Dalı, Ankara, 102 s.
13. Hernson, J., 2012. RSV (Respiratuar Sinsityal Virüs) Enfeksiyonu (http://tr.healthline.com/ health/rsv-respiratuar-sinsityal-virues-enfeksi yonu) (Erişim tarihi: Temmuz 2016)
14. Ikuta, K., K. Hashimoto, H. Kaneko, S. Mori, K. Ohashi and T. Suzutani, 2012. Antiviral and Antibacterial Activities of an Extract of Blackcurrants (Ribes nigrum L.). Microbiol Immunol 56:805–809.
15. Kendir, G., 2012. Türkiye’de Doğal Olarak Yetişen Ribes L. Türleri Üzerinde Farmasötik Botanik Yönünden Araştırmalar (Doktora Tezi). Ankara Üniversitesi Sağlık Bilimleri Enstitüsü Farmasötik Botanik Anabilim Dalı, Ankara, 384 s.
16. Kılıç, C.S., M. Koyuncu, T. Özek and K.H.C. Başer, 2008. Essential Oil of the Leaves of Ribes nigrum L. From Turkey. Journal of Essential Oil Research 20(6):512–514.
17. Knox, Y.M., K. Hayashi, T. Suzutani, M. Ogasawara, I. Yoshida, R. Shiina, A. Tsukui, N. Terahara and M. Azuma, 2001. Activity of Anthocyanins from Fruit Extract of Ribes nigrum L. against Influenza A and B viruses. Acta Virologica 45:209–215.
18. Krisch, J., L. Galgoczy, T. Papp and C. Vagvölgyi, 2009. Antimicrobial and Antioxidant Potential of Waste Products Remaining After Juice Pressing. Annals of the Faculty of Engineering Hunedoara–Journal of Engineering 7(4):131–134.
19. Nohynek, L.J., H.L. Alakomi, M.P. Kahkönen, M. Heinonen, I. M. Helander, K. M. Oksman–Caldentey and R. H. Puupponen–Pimia, 2006. Berry Phenolics: Antimicrobial Properties and Mechanisms of Action against Severe Human Pathogen. Nutrition and Cancer 54(1):18–32.
20. Nour, V., I. Trandafir and M.E. Ionica, 2011. Ascorbic Acid, Anthocyanins, Organic Acids and Mineral Content of Some Black and Red Currant Cultivars. Fruits 66(5):353–362.
21. Oprea, E., V. Radulescu, C. Balotescu, V. Lazar, M. Bucur, P. Mladin and I.C. Farcasanu, 2008. Chemical and Biological Studies of Ribes nigrum L. Buds Essential Oil. Bio Factors 34:3–12.
22. Ördögh, L., L. Galgoczy, J. Krisch, T. Papp and C. Vagvölgyi, 2010. Antioxidant and Antimicrobial Activities of Fruit Juices and Pomace Extracts against Acne–Inducing Bacteria. Acta Biologica Szegediensis 54(1):45–49.
23. Pehluvan, M. ve M. Güleryüz, 2004. Ahududu ve Böğürtlenlerin İnsan Sağlığı Açısından Önemi. Bahçe 33(1–2):51–57.
24. Picci, V., 1980. The Exploitation of Medicinal Plants of the Mediterranean Area. Journal of Ethnopharmacology 2(1):81–89.
25. Pinto, M.S., Y. Kwon, E. Apostolidis, F.M. Lajolo, M.I. Genovese and K. Shetty, 2010. Evaluation of Red Currants (Ribes rubrum L.), Black Currants (Ribes nigrum L.), Red and Green Gooseberries (Ribes uva–crispa) for Potential Management of Type 2 Diabetes and Hypertension Using in vitro Models. Journal of Food Biochemistry 34(3):639–660.
26. Poisson, J.P., M. Narce, Y.S. Huang and D.E. Mills, 1996. γ–Linolenic Acid Biosynthesis and Chain Elongation in Fasting and Diabetes Mellitus. In γ–Linolenic Acid. Metabolism and Its Roles in Nutrition and Medicine. AOCS Press: Champaign, IL: 259–272.
27. Puupponen–Pimia, R., L. Nohynek, C. Meier, M. Kahkonen, M. Heinonen, A. Hopia and K.M. Oksman–Caldentey, 2001. Antimicrobial Properties of Phenolic Compounds from Berries. Journal of Applied Microbiology 90(4):494–507.
28. Radovanovic, B., A. Milenkovic-Andjelkovic, A. Radovanovic and M. Andjelkovic, 2015. HPLC Analysis of Phenolic Compounds and Antioxidant Activity of Ribes Fruit Leaves. XX Savetovanje O Biotehnologiji 20(22):341–346.
29. Rauha, J.P., S. Remes, M. Heinonen, A. Hopia, M. Kahkönen, T. Kujala, K. Pihlaja, H. Vuorela and P. Vuorela, 2000. Antimicrobial Effects of Finnish Plant Extracts Containing Flavonoids and Other Phenolic Compounds. International Journal of Food Microbiology 56:3–12.
30. Saric–Kundalic, B., C. Dobes, V. Klatte–Asselmeyer and J. Saukel, 2010. Ethnobotanical Study on Medicinal Use of Wild and Cultivated Plants in Middle, South and West Bosnia and Herzegovina. Journal of Ethnopharmacology 131(1):33–55.
31. Sivalingam, G. and N. Sriram, 2013. Anti–Diabetic Activity of Ribes nigrum Fruit Extract in Alloxan Induced Diabetic Rats. International Journal of Pharmaceutical Sciences and Research 4(3):1196–1201.
32. Soto–Vaca, A., J.N. Losso, Z. Xu and J.W. Finley, 2012. Evolution of Good Polyphenolics from Color and Flavor Problems to Health Benefits. Journal of Agriculture Food Chemistry 60(27):6658–6677.
33. Tabart, J., T. Franck, C. Kevers, J. Pincemail, D. Serteyn, J.O. Defraigne and J. Dommes, 2012. Antioxidant and Anti–inflammatory Activities of Ribes nigrum Extracts. Food Chemistry 131(4):1116–1122.
34. Takata, R., R. Yamamoto, T. Yanai, T. Konno and T. Okubo, 2005. Immunostimulatory Effects of a Polysaccharide–Rich Substance with Antitumor Activity Isolated from Blac Currant (Ribes nigrum L.). Bioscience, Biotechnology and Biochemistry 69(11):2042-2050.
35. Vagiri, M., A. Ekholm, S.C. Andersson, E. Johansson and K. Rumpunen, 2012. An Optimized Method for Analysis of Phenolic Compounds in Buds, Leaves and Fruits of Black Currant (Ribes nigrum L.). Journal of Agriculture Food Chemistry 60(42):10501–10510.
36. Wang, S.Y and H. Lin, 2000. Antioxidant Activity in Fruits and Leaves of Blackberry, Raspberry and Strawberry Varies with Cultivar and Developmental Stage. Journal of Agriculture Food Chemistry 48(200):140-146.
37. Wikipedia, 2016. Caryophyllene (https://en. wikipedia.org/wiki/caryophyllene). (Erişim tarihi: Ağustos 2016)
38. Wikipedia, 2016. Humulene. (https://en. wikipedia.org/wiki/humulene). (Erişim tarihi: Ağustos 2016)
39. Wu, Q.K., J.M. Koponen, H.M. Mykkanen and A. R. Toronen, 2007. Berry Phenolic Extracts Modulate the Expression of p21WAF1 and Bax but Not Bcl–2 in HT–29 Colon Cancer Cells. Journal of Agricultural and Food Chemistry 55:1156–1163.