Üzümsü Meyvelerdeki Antikanserojen Fenolik Bileşikler

Year 2016, Volume: 45 Issue: (Özel Sayı 2) 5. Uluslararası Üzümsü Meyveler Sempozyumu, 37 - 46, 31.12.2016

Mustafa Kenan Geçer Müttalip Gündoğdu Yakup Erdal Ertürk

Abstract

Bu çalışmada, üzümsü meyvelerin sahip oldukları fenolik bileşikler ve bunların insan sağlığı üzerine etkileri ile antikanserojen özellikleri açıklanmaya çalışılmıştır. Meyvelerde bulunan bir çok fenolik bileşikler özellikle tat ve aroma ile renk oluşturucu özelliğe sahiptirler. Yapılan çalışmalarla bilhassa üzümsü meyvelerin içerdikleri fenolik bileşikler vasıtasıyla değişik kanserleri önlemede önemli katkılar sağladıkları anlaşılmıştır. Bu bileşikler, fenolik asitler ve flavonoidler olarak iki ana gruba ayrılmaktadır. Yapısal farklılıklarından dolayı bugüne kadar oldukça fazla sayıda fenolik bileşik tespit edilmiştir ve başta bitkisel ürünler olmak üzere gıdadan ilaç endüstrisine kadar birçok alanda tat ve aroma verici, renklendirici ve koruyucu olarak kullanılmaktadırlar. Ayrıca çoğu fenolikler bir taraftan antioksidan özellikleri sayesinde kalp hastalıkları ve bazı kanser türlerini önleyici ajanlar olarak kullanılırken, diğer taraftan bağışıklık sistemini koruma görevi üstlenen takviye gıdalar olarak ta önemli bir yere sahip olmuşlardır. Bu bakımdan değerlendirildiğinde; üzümsü meyvelerin önemi, günlük beslenmede lezzetli meyveler olarak kullanılmasından ziyade sahip oldukları bu kimyasal nitelikleri bakımından sağladıkları faydalar sebebiyle çok daha artmaktadır. Taze tüketiminin yanı sıra gıda sanayisi tarafından farklı ve cazibesi yüksek ürünlerin imalatında kullanımından ve insan sağlığına etkisinden dolayı, her geçen gün bu ürünlerin talebi artmakta, üreticiler için üretimi artırma dolayısı ile alternatif bir gelir kaynağı oluşturmaktadır. Çalışmada, üzümsü meyvelerin sahip oldukları fenolik bileşikler sayesinde hem işlenmiş ürün olarak hem de taze tüketimde değerlerinin anlaşılması açısından önemli noktalara değinilmiş ve daha kapsamlı çalışmalar yapılmasının gerekliliği vurgulanmıştır.

Keywords

Fenolik bileşikler , sağlık , üzümsü meyve tüketimi ve gelir kaynağı

Anti–Carcinogenic Phenolic Compounds in Berry Fruits

Abstract

In this study, it was endeavoured to explain phenolic compounds of berry fruits, their effects on human health and their anti–carcinogenic properties. Many phenolic compounds found in fruits especially have flavour, aroma and coloring characteristics. It was understood in previous studies that especially berry fruits made significant contributions to prevent various cancers thanks to phenolic compounds they contain. These compounds were divided into two major groups as phenolic acids and flavonoids. A great number of phenolic compounds was determined until today due to their structural differences and they are used as flavorant, colorant and preservative in numerous fields from food to drug industry, particularly in herbal products. Most phenolics are also used as agents preventing heart diseases and certain cancer types thanks to their antioxidant properties; on the other hand, they have an important place as food supplements undertaking a role of protecting immunity system. When it is assessed in this aspect; importance of berry fruits has increased much more due to benefits they provide in terms of these chemical qualifications rather than their use as delicious fruits in daily nutrition. In addition to their fresh consumption, demand for these products has increasing day by day due to their use in manufacturing different and highly attractive products by food industry and their effect on human health and they have become an alternative income source for producers to increase production. In the study, important points were mentioned in terms of understanding value of berry fruits in consumption both as processed product and freshly owing to their phenolic compounds and necessity of conducting more comprehensive studies was emphasized.

Keywords

Phenolic compounds , health , berry fruit consumption and income source

References

• Amaro, L. F., M. T. Soares, C. Pinho, I. F. Almeida, V. O. Ferreira and O. Pinho, 2012. Influence of Cultivar and Storage Conditions in Anthocyanin Content and Radical–Scavenging Activity of Strawberry Jams. International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering 6(9):656–660.
• Aras, Ö., 2006. Üzüm ve Üzüm Ürünlerinin Toplam Karbonhidrat, Protein, Mineral Madde ve Fenolik Bileşik İçeriklerinin Belirlenmesi (Yüksek Lisans Tezi). Süleyman Demirel Üniversitesi Bahçe Bitkileri Anabilim Dalı, Isparta.
• Balasundram, N., K. Sundram and S. Samman, 2006. Phenolic Compounds in Plants and Agri–Industrial By–Products: Antioxidant Activity, Occurrence and Potential Uses. Food Chemistry 99:191–203.
• Carlsen, H., M. C. Myhrstad, M. Thoresen, J. O. Moskaug and R. Blomhoff, 2003. Berry Intake Increases The Activity of The Gamma–Glutamylcysteine Synthetase Promoter in Transgenic Reporter Mice. J. Nutrition 133:2137–2140.
• Chen, P. N., S. C. Chu, H. L. Chiou, W. H. Kuo, C. L. Chiang and Y. S. Hsieh, 2006. Mulberry Anthocyanins, Cyanidin 3–Rutinoside and Cyanidin 3–Glucoside, Exhibited An Inhibitory Effect on The Migration and Invasion of A Human Lung Cancer Cell Line. Cancer Letters 235(2):248–259.
• Choi, J. W., A. Synytsya, P. Capek, R. Bleha, R. Pohl and Y. I. Park, 2016. Structural Analysis and Anti–Obesity Effect of a Pectic Polysaccharideisolated from Korean Mulberry Fruit Oddi (Morus alba L.). Carbohydrate Polymers 146:187–196.
• Çağlarırmak, N., 2006. Üzümsü Meyvelerde Polifenolik Bileşenlerin İnsan Sağlığı Yönünden Önemleri. II. Ulusal Üzümsü Meyveler Sempozyumu, Tokat, 317–321.
• Dembinska–Kiec, A., O. Mykkanen, B. Kiec–Wilk and H. Mykkanen, 2008. Antioxidant Phytochemicals against Type 2 Diabetes. British Journal of Nutrition 99(E–SUPPL. 1): 109–117.
• Dudonné, S., P. Dubé, F. F. Anhê, G. Pilon, A. Marette, M. Lemire, C. Harris, E. Dewailly and Y. Desjardins, 2015. Comprehensive Analysis of Phenolic Compounds and Abscisic Acid Profiles of Twelve Native Canadian Berries. Journal of Food Composition and Analysis 44:214–224.
• Forino, M., L. Tartaglione, C. Dell’Aversano and P. Ciminiello, 2016. NMR–Based Identification of The Phenolic Profile of Fruits of Lycium barbarum (Goji Berries). Isolation and Structural Determination of a Novel N–Feruloyl Tyramine Dimer as the Most Abundant Antioxidant Polyphenol of Goji Berries. Food Chemistry 194:1254–1259.
• Garcia–Salas, P., A. Morales–Soto, A. Segura–Carretero and A. Fernández–Gutiérrez, 2010. Phenolic–Compound–Extraction Systems for Fruit and Vegetable Samples. Molecules 15(12):8813–8826.
• Geçer, M. K., M. Gündoğdu, H. Yılmaz ve E. Orman, 2012. Üzümsü Meyvelerle Gelen Sağlık. IV. Ulusal Üzümsü Meyveler Sempozyumu, Antalya, s:117–126.
• Ghosh, D., T. K. McGhie, J. Zang, A. Adaim and M. Skinner, 2006. Effects of Anthocyanins and Other Phenolics of Boysenberry and Blackcurrant as Inhibitors of Oxidative Stress and Damage to Cellular DNA in SH–SY5Y and HL–60 Cells. J. of the Science of Food and Agr. 86(5):678–686.
• Gonzalez, C. V., M. L. Fanzone, L. E. Cortes, R. Bottini, D. C. Lijavetzky, C. L. Ballare and H. E. Boccalandro, 2015. Fruit–Localized Photoreceptors Increase Phenolic Compounds in Berry Skins of Field–Grown Vitis vinifera L. cv. Malbec. Phytochemistry 110:46–57.
• Gossard, A. A. and K. D. Lindor, 2011. Current Therapies for Nonalcoholic Fatty Liver Disease. Drugs Today 47(12):915–922.
• Giusti, M. M. and R. E. Wrolstad, 2003. Acylated Anthocyanins from Edible Sources and Their Applications in Food Systems. Biochemical Engineering J. 14:217–225.
• Hepsağ, F., İ. Hayoğlu ve B. Hepsağ, 2012. Karadut Meyvesinin Antosiyanin İçeriği ve Antosiyaninlerin Gıda Sanayinde Renk Maddesi Olarak Kullanım Olanakları. Gıda Teknolojileri Elektronik Dergisi 7(1):9–19.
• Johnson, J. L., J. A. Bomser, J. C. Scheerens and M. M. Giusti, 2011. Effect of Black Raspberry (Rubus occidentalis L.) Extract Variation Conditioned By Cultivar, Production Site and Fruit Maturity Stage on Colon Cancer Cell Proliferation. J. Agric. Food Chem. 59(5):1638–1645.
• Juranic, Z., Z. Zizak, S. Tasic, S. Petrovic, S. Nidzovic, A. Leposavic and T. Stanojkovic, 2005. Antiproliferative Action of Water Extracts of Seeds or Pulp of Five Different Raspberry Cultivars. Food Chem. 93:39–45.
• Kafkas, E., A. Bozdoğan, A. Burgut, N. Türemiş, S. Paydaş Kargı ve T. Cabaroğlu, 2006. Bazı Üzümsü Meyvelerde Toplam Fenol ve Antosiyanin İçerikleri. II. Ulusal Üzümsü Meyveler Sempoz., Tokat, s:309–312.
• Katsube, T., N. Imawaka, Y. Kawano, Y. Yamazaki, K. Shiwaku and Y. Yamane, 2006. Antioxidant Flavonol Glycosides in Mulberry (Morus alba L.) Leaves Isolated Based on LDL Antioxidant Activity. Food Chemistry 97(1):25–31.
• Kaume, L., L. R. Howard and L. Devareddy, 2012. The Blackberry Fruit: A Review on Its Composition and Chemistry, Metabolism and Bioavailability and Health Benefits. J. Agric. Food Chem. 60(23):5716–5727.
• Keating, S. E., D. A. Hackett, J. George and N. A. Johnson, 2012. Exercise and Non–Alcoholic Fatty Liver Disease: A Systematic Review and Meta–Analysis. Journal of Hepatology 57(1):157–166.
• Keen, C. L., R. R. Holt, P. I. Oteiza, C. G. Fraga and H. H. Schmitz, 2005. Cocoa Antioxidants and Cardiovascular Health. Am. J. Clin. Nutr. 81:298–303.
• Kızılet, E. ve R. E. Anlı, 2006. Kaliteli Kırmızı Şaraplarda Bazı Antioksidan Fenolik Bileşikler. Türkiye 9. Gıda Kongresi, Bolu, s:941–944.
• Kim, H. G., M. S. Ju, J. S. Shim, M. C. Kim, S. H. Lee, Y. Huh, S. Y. Kim and M. S. Oh, 2010. Mulberry Fruit Protects Dopaminergic Neurons in Toxin–Induced Parkinson’s Disease Models. British Journal of Nutrition 104:8–16.
• Kurilich, A. C., B. A. Clevidence, S. J. Britz, P. W. Simon and J. A. Novotny, 2005. Plasma and Urine Responses Are Lower for Acylated vs Nonacylated Anthocyanins from Raw and Cooked Purple Carrots. J. Agric. Food Chem. 53(16):6537–6542.
• Lansky, E. P. and R. A. Newman, 2007. Punica granatum (pomegranate) and Its Potential for Prevention and Treatment of Inflammation and Cancer. Journal of Ethnopharmacology 109(2):177–206.
• Lee, S. H., E. Jeong, S. S. Paik, J. H. Jeon, S. W. Jung, H. B. Kim, M. Kim, M. H. Chun and I. B. Kim, 2014. Cyanidin–3–glucoside Extracted from Mulberry Fruit Can Reduce N–methyl–N–nitrosourea–Induced Retinal Degeneration in Rats. Current Eye Research 39(1):79–87.
• Mahmood, T., A. M. Abas and N. Saari, 2012. Effect of Maturity on Phenolics (Phenolic Acids and Flavonoids) Profile of Strawberry Cultivars and Mulberry Species from Pakistan. Int. J. Mol. Sci. 13:4591–4607.
• Milbury, P. E., 2008. Berries and Cancer. Complementary and Alternative Therapies and the Aging Population: An Evidence–Based Approach (Chapter 17). Elsevier Books, 597 pages.
• Muraki, I., F. Imamura, J. E. Manson, F. B. Hu, W. C. Willett, R. M. Van Dam and Q. Sun, 2013. Fruit Consumption and Risk of Type 2 Diabetes: Results from Three Prospective Longitudinal Cohort Studies, BMJ: 1–15.
• Nizamlıoğlu, N. M. ve S. Nas, 2010. Meyve ve Sebzelerde Bulunan Fenolik Bileşikler; Yapıları ve Önemleri. Gıda Teknolojileri Elektronik Dergisi 5(1):20–36.
• Patthamakanokporn, O., P. Puwastien, A. Nitithamyong and P. P. Sirichakwal, 2008. Changes of Antioxidant Activity and Total Phenolic Compounds during Storage of Selected Fruits. Journal of Food Composition and Analysis 21(3):241–248.
• Pehluvan, M. ve M. Güleryüz, 2004. Ahududu ve Böğürtlenlerin İnsan Sağlığı Açısından Önemi. Bahçe 33(1–2):51–57.
• Proteggente, A. R., A. S. Pannala, G. Paganga, L. Van Buren, E. Wagner, S. Wiseman, F. Van De Put, C. Dacombe and C. A. Rice–Evans, 2002. The Antioxidant Activity of Regularly Consumed Fruit and Vegetables Reflects Their Phenolic and Vitamin C Composition. Free Radic. Res. 36(2):217–233.
• Reyes–Carmona, J., G. G. Yousef, R. A. Martinez–Penichhe and M. A. Lila, 2005. Antioxidant Capacity of Fruit Extracts of Blackberry (Rubus sp.) Produced in Different Climatic Regions. Journal of Food Science 70(7):497–503.
• Simopoulos, A. P. and N. Salem, 1996. Fatty Acids and Lipids from Cell Biology to Human Disease. Lipids–Chicago–American Oil Chemists Society 31, s–1.
• Song, H., J. Lai, Q. Tang and X. Zheng, 2016. Mulberry Ethanol Extract Attenuates Hepatic Steatosis and Insulin Resistance in High–Fat Diet–Fed Mice. Nurition Research 36:710–718.
• Teleszko, M. and A. Wojdyło, 2015. Comparison of Phenolic Compounds and Antioxidant Potential between Selected Edible Fruits and Their Leaves. Journal of Functional Foods 14:736–746.
• Tetens, I. and S. Alinia, 2009. The Role of Fruit Consumption in the Prevention of Obesity. J. of Horticultural Science & Bio–technology ISAFRUIT Special Issue: 47–51.
• Tudor, V., C. G. Manole, R. Teodorescu, A. Asanica, I. D. Barbulescu, 2015. Analysis of Some Phenolic Compounds and Free Radical Scavenging Activity of Strawberry Fruits during Storage Period. Agriculture and Agricultural Science Procedia 6:157–164.
• Turhan, İ., N. Tetik ve M. Karhan, 2007. Andız Pekmezi Üretimi ve Bileşimi. Gıda Teknolojileri Elektronik Dergisi 2:65–69.
• Wang, S. Y. and H. S. Lin, 2000. Antioxidant Activity in Fruits and Leaves of Blackberry, Raspberry and Strawberry Varies with Cultivar and Developmental Stage. J. Agric. Food Chem. 48(2):140–146.
• Wang, Y., L. Xiang, C. Wang, C. Tang and X. He, 2013. Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyp–henolenhanced Extract. plosone 8(7):e71144. doi:10.1371/ journal.pone. 0071144.
• Wang, S., N. Moustaid–Moussa, L. Chen, H. Mo, A. Shastri, R. Su, R. Bapat, I. Kwun and C. L. Shen, 2014. Novel Insights of Dietary Polyphenols and Obesity. J. Nutr. Biochem. 25(1):1–18.
• Withy, L. M., T. T. Nguyen, R. E. Wrolstad and D. A. Heatherbell, 1993. Storage Changes in Anthocyanin Content of Red Raspberry Juice Concentrate. Journal of Food Science 58(1):190–192.
• Valenti, L., P. Riso, A. Mazzocchi, M. Porrini, S. Fargion and C. Agostoni, 2013. Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity: 1–8.
• Yang, X., L. Yang and H. Zheng, 2010. Hypolipidemic and Antioxidant Effects Ofmulberry (Morus alba L.) Fruit in Hyperlipidaemia Rats. Food and Chemical Toxicology 48(8–9):2374–2379.
• Yağcı, C., M. C. Toker ve G. Toker, 2008. Bitki Doku Kültürü Yoluyla Üretilen Flavonoitler. Türk Bilimsel Derlemeler Dergisi 1(1):47–58.
• Yılmaz, H., 2009. Çilek. Hasad Yayınları, İstanbul. 350s.
• Zafar, M. S., F. Muhammad, I. Javed, M. Akhtar, T. Khaliq, B. Aslam, A. Waheed, R. Yasmin and H. Zafar, 2013. White Mulberry (Morus alba): A Brief Phytochemical and Pharmacological Evaluations Account. Int. J. Agric. Biol. 15(3):612–620.