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Coronavirus ve Fitoterapi

Year 2020, Volume: 1 Issue: 2, 49 - 57, 09.05.2020

Abstract

Dünya Sağlık Örgütü tarafından, 2020 yılının şubat ayında, SARS-CoV-2 olarak adlandırılan ve COVID-19 hastalığına neden olan virüs pandemi nedeni olarak ilan edilmiştir. Ani gelişen solunum sıkıntısıyla ortaya çıkan alt solunum sistemi tutulumu özellikle immun yetersizliği olan bireylerde mortal seyretmektedir.
Halihazırda SARS-CoV-2’yi hedefleyen etkili spesifik bir ilaç tanımlanmış değildir. Esas olan; hastalık öncesinde immuniteyi artırmak, hastalık etkeniyle karşılaşıldığında ise kimyasal ilaçların beklenen/olası yan etkilerini belirli oranda azaltılarak hastanın tedaviye uyumunun artırılmasıdır.
COVID-19 enfeksiyonunun tedavisinde fitoterapötik düzeyde Curcuma Longa, Vitamin D, Vitamin C, Vitamin A, Zn, Fe, Propolis, Scutellaria baicalensis, Glycyrrhiza glabra, Allium cepa, Malus domestica, Solanum lycopersicum, Fragaria, Matricaria recutita, Petroselinum crispum, Apium graveolens, Allium sativum, Quercetin, Astragalus membranaceus, Miselyum Mantarı Ekstresi, Mentha piperita, Andrographis paniculata, Rheum Palmatum, Aloe vera, Salvia officinalis, Melissa officinalis ,Rosa canina, Nigella Sativa ve Rhus typhina kullanılabilir.
Ayrıca Geleneksel Çin Tıbbı’na ait Saposhnikoviae divaricata, Rhizoma Atractylodis Macrocephalae, Lonicerae Japonicae Flos, Fructus forsythia, Atractylodis Rhizoma, Radix platycodonis, Agastache rugosa, Cyrtomium fortune J. Sm, ShuFengJieDu ve Lianhuaqingwen kapsülleri önerilebilir.
GÇT'da kullanılan tıbbi bitkilerin viruslerin hücreye tutunmasını, hücre içine girmesini, sinsisyal formasyon oluşumunu inhibe ettiği, hava yolu inflamasyonunu azalttığı, interferon sekresyonu ve immun sistem stimulasyonu yaptığı bildirilmiştir.
Coronavirus tedavisinde konvansiyonel tedavinin yanında fitoterapinin integratif bir tedavi yöntemi olarak kullanılmasının faydalı olacağı öngörülmektedir.

References

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Coronovirus and Pyhtotherapy

Year 2020, Volume: 1 Issue: 2, 49 - 57, 09.05.2020

Abstract

In February 2020, the virus called SARS-CoV-2 causing COVID-19 disease was announced by the World Health Organization as the cause of the pandemia. Lower respiratory tract involvement with sudden developing respiratory distress is especially mortal in individuals with immune deficiency. An effective specific drug currently targeting SARS-CoV-2 has not been identified yet. Main purpose is; to increase the immunity before the disease and to increase the patient's compliance to the treatment by reducing the expected / possible side effects of chemical drugs during the disease. At the phytotherapeutic level in the treatment of COVID-19 infection, Curcuma Longa, Vitamin D, Vitamin C, Vitamin A, Zinc (Zn), Iron (Fe), Propolis, Scutellaria baicalensis, Glycyrrhiza glabra, Allium cepa, Malus domestica, Solanum lycopersicum, Fragaria, Matricaria recutita, Petroselinum crispum, Apium, Allium sativum, Quercetin, Astragalus membranaceus, Mycelium Mushroom Extract, Mentha piperita, Andrographis paniculata, Rheum Palmatum, Aloe vera, Salvia officinalis, Melissa officinalis, Rosa canina, Nigella Sativa, and Rhus typhina can be used. In Traditional Chinese Medicine (TCM), Saposhnikoviae divaricata, Rhizoma Atractylodis Macrocephalae, Lonicerae Japonicae Flos, Fructus forsythia, Atractylodis Rhizoma, Radix platycodonis, Agastache rugosa, Cyrtomium fortune J. Sm, Shu Feng Ji eDu and Lian hua qing wen capsules can be recommended. It has been published that medicinal plants used in TCM; inhibit the attachment of viruses to the cell, the entry into the cell, the formation of syncytial formation, reduce airway inflammation, increase interferons secretion and immune system stimulation. It is predicted that it would be beneficial to use phytotherapy as an integrative treatment method besides conventional treatment in COVID-19.

References

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  • Albanna EAM, Ali YF, & Elkashnia RAM. (2010). Vitamin D and LL-37 in children with pneumonia. Egypt J Pediatr Allergy Immunol 2010;8(2):81-86.
  • AlHariri M. (2019). Immune's-boosting agent: Immunomodulation potentials of propolis. Journal of family & community medicine, 26(1), 57–60. https://doi.org/10.4103/jfcm.JFCM_46_18
  • Arreola, R., Quintero-Fabián, S., López-Roa, R. I., Flores-Gutiérrez, E. O., Reyes-Grajeda, J. P., Carrera-Quintanar, L., & Ortuño-Sahagún, D. (2015). Immunomodulation and anti-inflammatory effects of garlic compounds. Journal of immunology research, 2015, 401630. https://doi.org/10.1155/2015/401630
  • Barak, V., Halperin, T., & Kalickman, I. (2001). The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. European cytokine network, 12(2), 290–296.
  • Başer HC. (2018) Tıbbi Bitkiler ve Sağlığımız, Fitomed, Sayı 2, 8-11
  • Benson, K. F., Stamets, P., Davis, R., Nally, R., Taylor, A., Slater, S., & Jensen, G. S. (2019). The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro. BMC complementary and alternative medicine, 19(1), 342. https://doi.org/10.1186/s12906-019-2681-7
  • Burger, R. A., Torres, A. R., Warren, R. P., Caldwell, V. D., & Hughes, B. G. (1997). Echinacea-induced cytokine production by human macrophages. International journal of immunopharmacology, 19(7), 371–379. https://doi.org/10.1016/s0192-0561(97)00061-1
  • Chandrasekaran, C. V., Murali, B., Deepak, M., & Agarwal, A. (2012). In vitro comparative evaluation of non-leaves and leaves extracts of Andrographis paniculata on modulation of inflammatory mediators. Anti-inflammatory & anti-allergy agents in medicinal chemistry, 11(2), 191–197. https://doi.org/10.2174/187152312803305731
  • Chen, C., Zuckerman, D. M., Brantley, S., Sharpe, M., Childress, K., Hoiczyk, E., & Pendleton, A. R. (2014). Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication. BMC veterinary research, 10, 24. https://doi.org/10.1186/1746-6148-10-24
  • Chen, H., Lin, H., Xie, S., Huang, B., Qian, Y., Chen, K., Niu, Y., Shen, H. M., Cai, J., Li, P., Leng, J., Yang, H., Xia, D., & Wu, Y. (2019). Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination. Toxicology and applied pharmacology, 365, 19–29. https://doi.org/10.1016/j.taap.2018.12.019.
  • Cheng R. (2020). Successful High-Dose Vitamin C Treatment of Patients with Serious and Critical COVID-19 Enfection. Orthomoleculer Medicine News Service.
  • Choe, J. Y., & Kim, S. K. (2017). Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines. Inflammation, 40(3), 980–994. https://doi.org/10.1007/s10753-017-0542-4
  • Choi, J. G., Lee, H., Kim, Y. S., Hwang, Y. H., Oh, Y. C., Lee, B., Moon, K. M., Cho, W. K., & Ma, J. Y. (2019). Aloe vera and its Components Inhibit Influenza A Virus-Induced Autophagy and Replication. The American journal of Chinese medicine, 47(6), 1307–1324. https://doi.org/10.1142/S0192415X19500678
  • Del Prete A, Scalera A, Iadevaia MD, Miranda A, Zulli C, Gaeta L, Tuccillo C Federico A, & Loguercio C. (2012). Herbal Products: Benefits, Limits and Applications in Chronic Liver Disease. Evidence-Based Complementary and Alternative Medicine. Article ID 837939 , https://doi.org/10.1155/2012/837939
  • Demirezer Ö. (2011). FFD Monografları Tedavide Kullanılan Bitkiler. Basım Yılı: 2011, ISBN 9789755670737
  • Ding, T., Wang, S., Zhang, X., Zai, W., Fan, J., Chen, W., Bian, Q., Luan, J., Shen, Y., Zhang, Y., Ju, D., & Mei, X. (2018). Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. Phytomedicine : international journal of phytotherapy and phytopharmacology, 41, 45–53. https://doi.org/10.1016/j.phymed.2018.01.026
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There are 55 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Review Articles
Authors

Demet Uçar 0000-0003-3582-5515

Kanat Tayfun 0000-0002-5162-6797

Ahmet Yaser Müslümanoğlu 0000-0002-4025-7092

Mehmet Zafer Kalaycı This is me 0000-0002-8691-0886

Publication Date May 9, 2020
Published in Issue Year 2020 Volume: 1 Issue: 2

Cite

APA Uçar, D., Tayfun, K., Müslümanoğlu, A. Y., Kalaycı, M. Z. (2020). Coronavirus ve Fitoterapi. Bütünleyici Ve Anadolu Tıbbı Dergisi, 1(2), 49-57.

Bütünleyici ve Anadolu Tıbbı Dergisi

Journal of Integrative and Anatolian Medicine