Determination and analytical evaluation of chromium level in urines of workers that exposure the heavy metal using ICP-MS

Abstract

Some heavy metals lead serious health problems to man due to high toxicity. This study aimed to analysis and assessment chromium concentrations in urine of laboratory workers working at the intensive waste water. As a part of this study, urine samples were taken, at the end of the shift, from laboratory workers (n=6, age range 24 to 33) that exposed the heavy metals. Chromium concentrations (ngL-1andµgL-1) were determined by inductively coupled plasma mass spectrometry (ICP-MS). The analytical performance of the device was evaluated and their results have been given as ng L-1. Consequently, it was observed that, in the course of time, the chromium concentrations in the urine samples exceeded the limit values declared by the Agency for Toxic Substances and Disease Registry (ATSDR)

Keywords

• Chromium, Urine, ICP-MS

Ağır metale maruz kalan çalışanların idrarlarındaki krom değerlerinin ICP-MS ile belirlenmesi ve analitik değerlendirmesi

Abstract

. Bu çalışmada 3 aylık bir çalışma periyodunda, mesleki olarak ağır metale maruz kalmış laboratuar çalışanlarının idrarlarındaki krom değerleri belirlenmiş ve bu süreçteki değişim incelenmiştir. İdrar yoğunluklarını belirlemek için Endüktif Eşleşmiş Plazma Kütle Spektrometresi (ICP-MS) cihazı kullanılmıştır. Çalışmada analitik performans özellikleri de incelenmiş ve sonuçlar ngL-1 seviyelerinde verilmiştir. Çalışma sonucunda idrarların krom değerlerinin zamanla artış gösterdiği ve bu değerlerin zararlı maddeler ve hastalıklar birliği (ATSDR) tarafından belirtilen limit değerlerin üzerinde olduğu gözlenmiştir

Keywords

• Krom, İdrar, ICP-MS

References

1. ]. Högberg J., Alexander J., 1986. Handbook on the Toxicology of Metals 2, 482- 520.
2. [2]. http://www.atsdr.cdc.gov/toxprofiles/tp7-c1.pdf , (12.12.2013)
3. [3]. http://www.atsdr.cdc.gov/csem/chromium/docs/chromium.pdf., (18.03.2014)
4. [4]. Korallus U, Ulm K, Steinmann-Steiner-Haldenstaett W (1993). Bronchial carcinoma mortality in the German chromate producing industry: the effects of process modification’’. International Archives of Occupational and Environmental Health, 65, 171–178.
5. [5]. Angerera, J., Ewersb, U., Wilhelm. M., 2007. International Journal of Hgyiene and Environmental Health. Human Biomonitoring, 210, 201-228
6. [6]. Castillo, A., Boix, C., Fabregat, N., Roig-Navarro, A.F., and RodríguezCastrillón J.A., 2012. Rapid screeningof arsenic species in urine from exposed human by inductively coupled plasma mass spectrometry with germanium as internal standard. Journal of Analytical Atomic Spectrometry, 27, 354-358.
7. [7]. Schramel, P., Wendler, I., Angerer, J., 1997. The determination of metals (antimony, bismuth, lead, cadmium, mercury, palladium, platinum, tellurium, thallium, tin and tungsten) in urine samples by inductively coupled plasma-mass spectrometry. International Archives of Occupational and Environmental Health, 69(3), 219-223
8. [8]. Heitland, P., Köster, H.D., 2006. Biomonitoring of 30 trace elements in urine of children and adults by ICP-MS. Clinica Chimica Acta, 365(1-2), 310-8.

9. [9]. Nixon, D.E., Moyer, T.P., 1996. Routine clinical determination of lead,arsenic, cadmium, and thallium in urine and whole blood by inductively coupled plasmamass spectrometry. Spectrochimica Acta, 51(1), 13-25.
10. [10]. Marchante-Gayon, JM, Sariego, M.C., Garcia, J.I., Sanz-Medel, A., 1999. Multielemental trace analysis of biological materials using double focusing inductively coupled plasma mass spectrometry detection. Analytica Chimica Acta, 400, 307-320.
11. [11]. Goulle, J.P., Mahieu, L., Castermant, J. et al., 2005. Metal and metalloid multielementary ICP-MS validation in whole blood, plasma, urine and hair. Reference values. Forensic Science International, 153(1), 39-44.
12. [12]. Usuda, K., Kono, K., Hayashı, S. et al., 2006. determination of reference concentrations of strontium in urine by inductively coupled plasma atomic emission spectrometry. Environmental Health and Preventive Medicine, 11(1), 11-16.
13. [13]. Protocole de validation de techniques, 1985. Commission Validation de Techniques de la Socie´Te ´