Endometrium, serviks ve larinks kanserlerinin yoğunluk ayarlı radyoterapi tekniğinde doz homojenite indeksinin kantitatif olarak değerlendirilmesi ve homojenite indeks değerlerinin karşılaştırılması

Abstract

Bu araştırmada amaç; endometrium, serviks ve larinks kanserlerinin yoğunluk ayarlı radyoterapi (YART) tekniğinde 6 farklı homojenite indeks formülleri kullanılarak hesaplanan değerleri karşılaştırmak ve doz homojenitesi  için en iyi homojenite indeksini belirlemektir.

Bu calışmada, ELEKTA SYNERGY lineer hızlandırıcısında 6 MV   foton enerjisi ile dinamik Multi Lif Kolimatör (dMLC) yoğunluk ayarlı radyoterapi (YART) tedavi tekniği ile tedavi edilen 30 hastanın (10 endometrium, 10 serviks, 10 larinks) 6 farklı formülle hesaplanan homojenite indeks sonuçları değerlendirilmiştir. Yoğunluk ayarlı radyoterapi (YART) planları MONACO tedavi planlama sisteminde planlanmıştır. Ayrıca, homojenite indeksini etkileyen faktörler de incelenmiştir. Elde edilen veriler Sosyal Bilimler İçin İstatistik Programı (SPSS) istatistiksel analiz programı yardımıyla analiz edilmiştir.

Keywords

• Homojenite,indeks,YART,doz,monaco

Comparison of homogeneity indices for quantitative evaluation of dose homogeneity for ımrt treatments of endometrium, cervix and larynx cancers

Abstract

The aim of this study  is to compare results that are calculated using 6  different homogeneity index formulae for Intensity Modulated Radiation Therapy (IMRT) in endometrium , cervix and larynx cancers and to determine the best homogeneity indices for dose homogeneity.

In this study 6 different homogeneity index formulae were evaluated for 30 patients for endometrium, cervix and larynx cancer patients receiving dynamic Multileaf Collimator (dMLC) Intensity Modulated Radiation Therapy (IMRT) treatments on ELEKTA SYNERGY linear accelerator with 6 MV photon beam. Intensity Modulated Radiation Therapy (IMRT) plannings were carried out on MONACO treatment planning system. The factors that could effect the homogeneity indices were examined. The data obtained that were analyzed with Statistical Package for the Social Sciences (SPSS) statistical programme.

Keywords

• Homogeneity,indices,IMRT,dose,monaco

References

1. Bilge, H., Planların Değerlendirilmesi, in Çetingöz, R., Garipağaoğlu, M., Uzal, C., Bilge, H., Gökçe, Ş.Ç., Özyiğit, G. ve Yıldız, O.G., Temel ve Klinik Radyoterapi, Hürriyet Matbaa, 82-83, İzmir, (2013).
2. Van’t ,Riet, A., Mak, A.C., Moerland, M.A.ve Elders, L.H., A conformation number to quantify the degree of conformality in brachytherapy and external beamm irradiation: Application to the prostate. International Journal Radiation Oncology Biology Physics.37, 731-736 (1997).
3. Yu, C., Jozsef, G., Apuzzo, M.L.ve Petrovich, Z., Dosimetric comparison of cyberKnife with other radiosurgical modalities for an ellipsoidal target. Neurosurgery.53, 1155-62.discussion 1162-1163 (2003).
4. ICRU83, Prescribing,Recording and Reporting İntensity modulated Photon Beam Therapy, IMRT, ICRU, (2010).
5. Kataria, T., Sharma, K., Subramani, V., Karrthick, K.P. ve Bisht, S.S., Homogeneity Index: An objevtice tool for assessment of conformal radiation treatments. Journal Medical Physics, 37, 4, 207-213 (2012).
6. Yoon, M., Park, S.Y., Shin, D., Lee, S.B., Pyo, H.R., Kim, D.Y. ve Cho, K.H., A new homogeneity index based on statistical analysis of the dose-volume histogram. Journal of Applied Clinical Medical Physics, 8, 2, 9-17, (2007).
7. Semerenko, V.A., Reitz, B., Day, E., Qi, X.S., Miften, M. ve Li, X.A., Evaluation of a commercial biologically based IMRT treatment planning system. Medical Physics, 35, 5851-5860 (2008).
8. Wu, Q., Mohan, R., Morris, M., Lauve, A. ve Schmidt-Ullrich, R., Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: Dosimetric results. International Journal Radiation Oncology Biology Physics, 26, 573-585(2003).

9. Çelik, Z., Üç boyutlu konformal radyoterapide conformity index (CI), homogeneity index (HI) ve quality of coverage (QC) parametrelerinin hesaplanması ve hesaplanan değerlerin karşılaştırılması, Yükseklisans Tezi, Yıldırım Beyazıt Üniversitesi, Ankara, (2015).
10. Knoss, T., Kristensen, I. ve Nilsson, P., Volumetric and dosimetric evaluation of radiation treatment plans: Radiation conformity index. International Journal Radiation Oncology Biology Physics,42, 1169-1176 (1998).
11. Wu, V.W., Kwong, D.L. ve Sham, J.S., Target dose conformity in 3-dimensional conformal radiotherapy and intensity modulated radiotherapy. International Journal Radiation Oncology Biology Physics,71, 201-206 (2004).
12. Wu, Q.R., Wessels, B.W., Einstein, D.B., Maciaunas, R.J., Kim, E.Y. ve Kinsella, T.J., Quality of coverage: Conformity measures for stereotactic Radiosurgery. Journal Applied Clinical Medical Physics, 4, 374-381 (2003).