Üç hücreli motif genelleme ile oluşturulan küçük ölçekli biyolojik sinir ağlarının bellek davranışı

Abstract

Biyolojik bellek yapısını ve fonksiyonlarını anlamak için teorik ve deneysel pek çok çalışma yapılmaktadır. Bu çalışmalarda biyolojik ağların, özel hücreler arası bağlantılardan (motifler) oluştuğu görülmüştür. Deneysel çalışmalar ışığında oluşturulan modeller üzerinde, biyolojik ağlardan oluşan bellek yapıları ve bu yapıların temel yapı taşı olan motifler incelenmektedir.  Çalışmamızda sinir hücresi, sadece soma bölümünden oluşan ve tek bölmeli hücre şeklinde modellendi.  Hücreler arası iletişim kimyasal sinaps şeklinde tercih edildi ve modelde hücreler arası iletişim incelendi.  Hücre rolleri giriş, ara ve çıkış olarak düşünülen üç hücreli motiflerde, uzun -ve kısa dönem bellek davranışı çalışıldı.  Üç hücreli motiflerin giriş, ara ve çıkış hücrelerinin çoklanması yöntemiyle oluşturulan (motif genelleme) küçük ölçekli biyolojik ağların, uzun -ve kısa dönem bellek davranışları tespit edildi.  Motiflerde ve motiflerden oluşan ağlarda yaptığımız çalışmalardan elde edilen bulgular karşılaştırıldı.  Biyolojik ağın, kendisini oluşturan motiflerle aynı bellek davranışını sergilediği gösterildi.  Böylece biyolojik ağların bellek davranışlarını anlayabilmek için öncelikle ağda bulunan motifler üzerinde daha detaylı çalışılması gerektiği ortaya konuldu.

Keywords

• Biyolojik ağ,kısa-dönem bellek,sinaptik iletişim,uzun-dönem bellek,uyarıcı ve engelleyici uyaran,üç hücreli motif

Memory behavior of small-scale biological neural networks generated by generalization of a three-cell motif

Abstract

Many theoretical and experimental studies are performed to understand the structure and functions of biological memory.  In these studies, it was seen that biological networks consisted of special intercellular connection (motifs).  On the models created in the light of experimental studies, the memory structures composed of biological networks and the basic building blocks of these structures are examined.  In our study, the nerve cell was modeled as a single compartment cell consisting only of soma section.  Intercellular communication was preferred in the form of chemical synapses and the intercellular communication was examined in the model.  Long-and short-term memory behavior was studied in three-cell motifs which were thought to be input, intermediate and output of cell roles.  Long-term and short-term memory behaviors of small-scale biological networks which were formed by multiplexing of input, intermediate and output cells (motif generalization) of three-cell motifs were determined.  The results of our studies in the networks consisting of motifs and motifs were compared.  It was shown that the biological network exhibited the same memory behavior as its motifs.  Thus, in order to understand the memory behaviors of the biological networks, it was revealed that the motifs in the network should be studied in more detail.

Keywords

• Biological network,short-term memory,synaptic communication,long-term memory,excitatory and inhibitory stimuli,three-cell motif

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