The effects of mutations on pericentromeric localization of shugoshin

Yıl 2022, Cilt: 24 Sayı: 2, 869 - 877, 08.07.2022

Begumhan Yılmaz Kardas , Serap Doğan

Öz

Elucidating the effects of mutations on protein-protein interactions can be useful for detecting damaged biological functions like chromosome segregations, because cellular structure and functions are mainly built on concerted interactions of proteins. Shugoshin (Sgo1) is one of those proteins that has many roles in correct chromosome segregation during mitosis and meiosis. One of the important aspects about Sgo1, to function properly, is the fact that it has to be on the chromosomal region surrounding the centromere (the pericentromere). However, some mutations can directly or indirectly affect the localization of Sgo1 and result in chromosomal instability which is known as the occasional gain/loss of chromosomes resulting in aneuploidy, cancer and other diseases. Therefore, this review focuses on the mutations that affect the pericentromeric localization of Sgo1.

Anahtar Kelimeler

Shugoshin, pericentromere, mutation, chromosomal instability, aneuploidy

Teşekkür

This work is produced from a part of PhD thesis of Begumhan Yilmaz Kardas. Authors would like to thank Adele Marston for introducing authors to this research area and the Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarships provided to Begumhan Yilmaz Kardas.

Mutasyonların şugoşinin perisentromerik lokalizasyonu üzerindeki etkileri

Öz

Mutasyonların protein-protein etkileşimleri üzerindeki etkilerinin aydınlatılması, kromozom segregasyonları gibi biyolojik fonksiyonlardaki hasarlarn tespiti için faydalı olabilir, çünkü hücresel yapı ve fonksiyonlar esas olarak proteinlerin uyumlu etkileşimleri üzerine kuruludur. Shugoshin (Sgo1), mitoz ve mayoz bölünme sırasında doğru kromozom ayrımında birçok rolü olan proteinlerden biridir. Sgo1'in düzgün çalışması için gerekli olan faktörlerden biri, bu proteinin sentromeri çevreleyen (perisentromer) kromozomal bölgede bulunması gerekliliğidir. Bununla birlikte, bazı mutasyonlar Sgo1'in lokalizasyonunu doğrudan veya dolaylı olarak etkileyebilir ve anöploidi, kanser ve diğer hastalıklarla sonuçlanabilen kromozom kazanımı/kaybı olarak bilinen kromozomal kararsızlığa neden olabilir. Bu nedenle, bu makale Sgo1'in perisentromerik lokalizasyonunu etkileyen mutasyonlara odaklanmaktadır.

Anahtar Kelimeler

Şugoşin, perisentromer, mutasyon, kromozomal instabilite, anöploidi

Kaynakça

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