Approach to systemic lupus erythematosus and skin lesions

Abstract

Abstract

Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that involves a broad spectrum of symptoms. The underlying cause of LE is unknown but the etiology is thought to be multifactorial and polygenic. Although it can occur in both genders, it has a higher incidence in women, commonly around 30 years of age. The cutaneous manifestations of lupus are pleomorphic. Various cutaneous manifestations of LE are divided into LE-specific and LE-nonspecific skin diseases based on histological criteria. Treatment is based on preventive measures, reversal of inflammation, prevention of damage to target organs and relief of adverse events due to pharmacological therapy. In this review, clinical signs, especially skin manifestations of SLE, diagnostic criteria and treatment options have been discussed.

Keywords: cutaneous lupus erythematosus, systemic lupus erythematosus, skin manifestations, therapy

Özet

Sistemik lupus eritematozus (SLE), geniş spektrumda semptomları barındıran, kronik otoimmün bir hastalıktır. Lupus eritematozusun (LE) nedeni tam olarak bilinmemektedir fakat etiyoloji multifaktöryel ve poligenik olabilir. Her iki cinsiyeti etkileyebilse de özellikle 30 yaş civarı kadınlarda insidansı daha yüksektir. Lupusun kutanöz bulguları polimorfiktir. Lupusun kutanöz bulguları histolojik kriterlere göre lupusa spesifik ve lupusa spesifik olmayan lezyonlar olarak ayrılmaktadır. Tedavi, koruyucu önlemler, inflamasyonun baskılanması, hedef organlardaki hasarın önlenmesi ve farmokolojik tedaviye bağlı yan etkilerin azaltılmasına dayalıdır. Bu derlemede, klinik bulgular, özellikle LE’un kutanöz bulguları, tanı kriterleri ve tedavi seçenekleri tartışılmıştır.

Anahtar sözcükler: kutanöz lupus eritematozus; sistemik lupus eritematozus; deri bulguları; tedavi

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