BibTex RIS Cite

Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride

Year 2013, , 116 - 122, 04.03.2014

Mustafa Alparslan Koray Ak , Emine Dinçer Cevdet Düger

https://doi.org/10.12808/bcs.v2i3.34

Abstract

Abstract

Aim. The objective of this study was to compare the efficacy of ketamine or lidocaine on relieving the pain during the injection of a new formulation of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride (MCT/LCT). Methods. This study including patients, ASA I and II, was conducted as double-blinded and placebo-controlled randomized trial on 75 subjects aged 18-65 years scheduled for elective surgical operation under general anesthesia. Propofol MCT/LCT 1% (2.5 mg/kg) plus 40 mg lidocaine, 10 mg ketamine, and normal saline were administered in groups I, II, and III, respectively. Scores of pain intensity and arm withdrawal were assessed during the propofol injection. Results. There was no significant difference among the study groups with regard to the ratios of no and mild pain (p>0.05); however, the ratios of moderate pain of the lidocaine and ketamine groups were significantly lower than that of the normal saline group (2% vs. 28%; p<0.05). The study groups were found comparable with regard to the arm withdrawal score (p>0.05). Conclusion. Propofol MCT/LCT as the new formation of propofol generally cause less pain during injection and for reducing its pain, ketamine 10 mg has similar effects with lidocaine40 mg.

Keywords: Propofol medium-chain triglyceride/long-chain triglyceride, lidocaine, ketamine, pain

Özet

Amaç. Orta zincirli trigliserit/uzun zincirli trigliserit (MCT/LCT) karışımı içeren yeni formülasyon propofolün enjeksiyon ağrısının giderilmesinde ketamin ve lidokainin etkinliğinin karşılaştırılması amaçlandı. Yöntem. Çalısma ASA I-II, 18-65 yaş arasında genel anestezi altında elektif cerrahi operasyon uygulanan 75 olgu üç gruba ayrılarak randomize, çift kör ve plasebo kontrollü olarak planlandı. Grup 1'e (n=25) 40 mg lidokain ile, grup 2'ye (n=25) 10 mg ketamin ile, ve grup 3'e (n=25) serum fizyolojik ile birlikte 2,5 mg/kg dozunda %1'lik propofol MCT/LCT verildi. Propofol enjeksiyonu sırasında ağrı yoğunluğu ve kol çekme skorlaması yapıldı. Bulgular. Ağrı görülmeme ve az ağrı görülme oranları gruplara göre anlamlı farklılık göstermezken (p>0,05); lidokain ve ketamin ile orta düzeyde ağrı oranları serum fizyolojik grubuna göre anlamlı olarak daha düşük bulundu (%28'e karşın %2; p<0,05). Gruplara göre kol çekme yanıtları arasında istatistiksel olarak anlamlı farklılık bulunmadı (p>0,05). Sonuç. Propofolun yeni formu olan propofol MCT/LCT genel olarak çok fazla enjeksiyon ağrısına neden olmazken, oluşabilecek ağrıyı önlemede 10 mg ketamin 40 mg lidokaine benzer etkinlik sağlayabilir.

Anahtar sözcükler: Propofol orta zincirli trigliserit/uzun zincirli trigliserit, lidokain, ketamin, ağrı

Keywords

Propofol medium-chain triglyceride/long-chain triglyceride lidocaine ketamine pain

References

  • Angst MS, Mackey SC, Zupfer GH, et al. Reduction of propofol injection pain with a double lumen i.v set. J Clin Anesth 1997; 9: 462-66.
  • Stark RD., Binks SM., Dukta VN., O’Connor KM., Arnstein MJA., Glen JB.: A review of the safety and tolerance of propofol (‘Diprivan’). Postgrad Med J. 61 (suppl3) : 152-56, 1985
  • Doenicke AW, Roizen MF, Rau J, O'Connor M, Kugler J, Klotz U, et al. Pharmacokinetics and pharmacodynamics of propofol in a new solwent. Anesth Analg 1997;85(6):1399-403.
  • Scott RP, Saunders DA, Norman J. Propofol: clinical strategies for preventing the pain of injection. Anaesthesia 1988;43(6):492-4.
  • Doenicke A, Roizen M, Rau J, et al. Reducing pain during propofol injection: the role of the solvent. Anesth Analg 1996; 82:472–4.
  • Babl J, Doenicke A, MGnch V. New propofol MCT/LCT fat emulsions as solvent: approach to reducing pain on injection of propofol? Eur Hosp Pharm 1995;1:15-21.
  • Özkoçak I, Altunkaya H, Özer Y, Ayoğlu H, Demirel CB, Çiçek E. Comparison of ephedrine and ketamine in preventing of injection pain and hypotension due to propofol induction. Eur J Anaesth 2005; 22: 44-8. 122

-

Year 2013, , 116 - 122, 04.03.2014

Mustafa Alparslan Koray Ak , Emine Dinçer Cevdet Düger

https://doi.org/10.12808/bcs.v2i3.34

Abstract

Amaç. Orta zincirli trigliserit/uzun zincirli trigliserit (MCT/LCT) karışımı içeren yeni formülasyon propofolün enjeksiyon ağrısının giderilmesinde ketamin ve lidokainin etkinliğinin karşılaştırılması amaçlandı. Yöntem. Çalısma ASA I-II, 18-65 yaş arasında genel anestezi altında elektif cerrahi operasyon uygulanan 75 olgu üç gruba ayrılarak randomize, çift kör ve plasebo kontrollü olarak planlandı. Grup 1'e (n=25) 40 mg lidokain ile, grup 2'ye (n=25) 10 mg ketamin ile, ve grup 3’e (n=25) serum fizyolojik ile birlikte 2,5 mg/kg dozunda %1’lik propofol MCT/LCT verildi. Propofol enjeksiyonu sırasında ağrı yoğunluğu ve kol çekme skorlaması yapıldı. Bulgular. Ağrı görülmeme ve az ağrı görülme oranları gruplara göre anlamlı farklılık göstermezken (p>0,05); lidokain ve ketamin ile orta düzeyde ağrı oranları serum fizyolojik grubuna göre anlamlı olarak daha düşük bulundu (%28’e karşın %2; p<0,05). Gruplara göre kol çekme yanıtları arasında istatistiksel olarak anlamlı farklılık bulunmadı (p>0,05). Sonuç. Propofolun yeni formu olan propofol MCT/LCT genel olarak çok fazla enjeksiyon ağrısına neden olmazken, oluşabilecek ağrıyı önlemede 10 mg ketamin 40 mg lidokaine benzer etkinlik sağlayabilir.

Keywords

Propofol orta zincirli trigliserit/uzun zincirli trigliserit lidokain ketamin ağrı

References

  • Angst MS, Mackey SC, Zupfer GH, et al. Reduction of propofol injection pain with a double lumen i.v set. J Clin Anesth 1997; 9: 462-66.
  • Stark RD., Binks SM., Dukta VN., O’Connor KM., Arnstein MJA., Glen JB.: A review of the safety and tolerance of propofol (‘Diprivan’). Postgrad Med J. 61 (suppl3) : 152-56, 1985
  • Doenicke AW, Roizen MF, Rau J, O'Connor M, Kugler J, Klotz U, et al. Pharmacokinetics and pharmacodynamics of propofol in a new solwent. Anesth Analg 1997;85(6):1399-403.
  • Scott RP, Saunders DA, Norman J. Propofol: clinical strategies for preventing the pain of injection. Anaesthesia 1988;43(6):492-4.
  • Doenicke A, Roizen M, Rau J, et al. Reducing pain during propofol injection: the role of the solvent. Anesth Analg 1996; 82:472–4.
  • Babl J, Doenicke A, MGnch V. New propofol MCT/LCT fat emulsions as solvent: approach to reducing pain on injection of propofol? Eur Hosp Pharm 1995;1:15-21.
  • Özkoçak I, Altunkaya H, Özer Y, Ayoğlu H, Demirel CB, Çiçek E. Comparison of ephedrine and ketamine in preventing of injection pain and hypotension due to propofol induction. Eur J Anaesth 2005; 22: 44-8. 122
There are 7 citations in total.

Details

Primary Language English
Journal Section Clinical Sciences
Authors

Mustafa Alparslan This is me

Koray Ak

Emine Dinçer This is me

Cevdet Düger This is me

Publication Date March 4, 2014
Published in Issue Year 2013

Cite

APA Alparslan, M., Ak, K., Dinçer, E., Düger, C. (2014). Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride. Basic and Clinical Sciences, 2(3), 116-122. https://doi.org/10.12808/bcs.v2i3.34
AMA Alparslan M, Ak K, Dinçer E, Düger C. Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride. Basic and Clinical Sciences. March 2014;2(3):116-122. doi:10.12808/bcs.v2i3.34
Chicago Alparslan, Mustafa, Koray Ak, Emine Dinçer, and Cevdet Düger. “Placebo-Controlled Comparison of Using Lidocaine or Ketamine to Reduce the Pain During Injection of Propofol Containing a Mixture of Medium-Chain triglyceride/Long-Chain Triglyceride”. Basic and Clinical Sciences 2, no. 3 (March 2014): 116-22. https://doi.org/10.12808/bcs.v2i3.34.
EndNote Alparslan M, Ak K, Dinçer E, Düger C (March 1, 2014) Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride. Basic and Clinical Sciences 2 3 116–122.
IEEE M. Alparslan, K. Ak, E. Dinçer, and C. Düger, “Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride”, Basic and Clinical Sciences, vol. 2, no. 3, pp. 116–122, 2014, doi: 10.12808/bcs.v2i3.34.
ISNAD Alparslan, Mustafa et al. “Placebo-Controlled Comparison of Using Lidocaine or Ketamine to Reduce the Pain During Injection of Propofol Containing a Mixture of Medium-Chain triglyceride/Long-Chain Triglyceride”. Basic and Clinical Sciences 2/3 (March 2014), 116-122. https://doi.org/10.12808/bcs.v2i3.34.
JAMA Alparslan M, Ak K, Dinçer E, Düger C. Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride. Basic and Clinical Sciences. 2014;2:116–122.
MLA Alparslan, Mustafa et al. “Placebo-Controlled Comparison of Using Lidocaine or Ketamine to Reduce the Pain During Injection of Propofol Containing a Mixture of Medium-Chain triglyceride/Long-Chain Triglyceride”. Basic and Clinical Sciences, vol. 2, no. 3, 2014, pp. 116-22, doi:10.12808/bcs.v2i3.34.
Vancouver Alparslan M, Ak K, Dinçer E, Düger C. Placebo-controlled comparison of using lidocaine or ketamine to reduce the pain during injection of propofol containing a mixture of medium-chain triglyceride/long-chain triglyceride. Basic and Clinical Sciences. 2014;2(3):116-22.