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The use of growth hormone in in vitro fertilization

Year 2013, , 123 - 127, 04.03.2014

Kübra Boynukalın , Tolga Güler

https://doi.org/10.12808/bcs.v2i3.35

Abstract

Abstract

Growth hormone (GH) is a 191 amino acid, single chain polypeptide hormone, produced, stored and secreted by somatotroph cells in the anterior pituitary gland. Normal fertility does not seem to require a normal GH axis. Aim of this review is to evaluate GH medication for controlled ovarian hyperstimulation (COH) protocols in IVF. All of the randomized controlled trials (RCTs) in the literature about this topic are small numbered. There is currently enough evidence to be moderately confident that adjuvant GH treatment undergoing IVF/ICSI treatment results in higher delivery rates but caution is required. Fertility specialists must design larger RCTs that may detect the effect of GH in IVF/ICSI treatment clearly.

Keywords: Growth hormone, controlled ovarian hyperstimulation

Özet

Büyüme hormonu (BH), ön hipofiz bezindeki somatotrof hücrelerce üretilen, depolanan ve salgılanan, 191 amino asitlik tek zincirli polipeptit bir hormondur. Normal fertilite için normal bir BH aksı şart değildir. Bu derlemede kontrollü ovaryan hiperstimülasyon sikluslarında BH kullanımının yeri irdelenmiştir. Literatürde bu konu işe ilgili randomize kontrollü çalışmalar küçük örneklem sayısı içerirler. Ancak, IVF sikluslarında adjuvan BH kullanımının daha yüksek doğum oranları ile ilişkili olduğunu söylemek için yeterli kanıt mevcuttur. İnfertilite uzmanları BH'nın IVF tedavisi üzerindeki etkisini daha net açıklayabilmek amacıyla daha büyük çapta randomize kontrollü çalışmalar dizayn etmelilerdir.

Anahtar sözcükler: Büyüme hormonu, kontrollü ovaryan hiperstimülasyon

Keywords

Growth hormone controlled ovarian hyperstimulation

References

  • Giudice LC. Insulin-like growth factors and ovarian follicular development. Endocr Rev. 1992 Nov;13(4):641-69.
  • Hull KL, Harvey S. Growth hormone: roles in female reproduction. J Endocrinol. 2001 Jan;168(1):1-23.
  • Yoshimura Y, Iwashita M, Karube M, Oda T, Akiba M, Shiokawa S, Ando M, Yoshinaga A, Nakamura Y. Growth hormone stimulates follicular development by stimulating ovarian production of insulin-like growth factor-I. Endocrinology. 1994 Sep;135(3):887-94.
  • Ovesen P, Ingerslev HJ, Orskov H, Ledet T. Effect of growth hormone on steroidogenesis, insulin-like growth factor-I (IGF-I) and IGF-binding protein-1 production and DNA synthesis in cultured human luteinized granulosa cells. J Endocrinol. 1994 Feb;140(2):313-9. de Boer JA, Schoemaker J, van der Veen EA. Impaired reproductive function in women treated for growth hormone deficiency during childhood. Clin Endocrinol (Oxf). 1997 Jun;46(6):681-9.
  • Hsu CJ, Hammond JM. Concomitant effects of growth hormone on secretion of insulin-like growth factor I and progesterone by cultured porcine granulosa cells. Endocrinology. 1987 Oct;121(4):1343-8.
  • Erickson GF, Garzo VG, Magoffin DA. Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab. 1989 Oct;69(4):716-24.
  • Mendoza C, Cremades N, Ruiz-Requena E, Martinez F, Ortega E, Bernabeu S, Tesarik J. Relationship between fertilization results after intracytoplasmic sperm 127

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Year 2013, , 123 - 127, 04.03.2014

Kübra Boynukalın , Tolga Güler

https://doi.org/10.12808/bcs.v2i3.35

Abstract

Büyüme hormonu (BH), ön hipofiz bezindeki somatotrof hücrelerce üretilen, depolanan ve salgılanan, 191 amino asitlik tek zincirli polipeptit bir hormondur. Normal fertilite için normal bir BH aksı şart değildir. Bu derlemede kontrollü ovaryan hiperstimülasyon sikluslarında BH kullanımının yeri irdelenmiştir. Literatürde bu konu işe ilgili randomize kontrollü çalışmalar küçük örneklem sayısı içerirler. Ancak, IVF sikluslarında adjuvan BH kullanımının daha yüksek doğum oranları ile ilişkili olduğunu söylemek için yeterli kanıt mevcuttur. İnfertilite uzmanları BH’nın IVF tedavisi üzerindeki etkisini daha net açıklayabilmek amacıyla daha büyük çapta randomize kontrollü çalışmalar dizayn etmelilerdir.

Keywords

Büyüme hormonu kontrollü ovaryan hiperstimülasyon

References

  • Giudice LC. Insulin-like growth factors and ovarian follicular development. Endocr Rev. 1992 Nov;13(4):641-69.
  • Hull KL, Harvey S. Growth hormone: roles in female reproduction. J Endocrinol. 2001 Jan;168(1):1-23.
  • Yoshimura Y, Iwashita M, Karube M, Oda T, Akiba M, Shiokawa S, Ando M, Yoshinaga A, Nakamura Y. Growth hormone stimulates follicular development by stimulating ovarian production of insulin-like growth factor-I. Endocrinology. 1994 Sep;135(3):887-94.
  • Ovesen P, Ingerslev HJ, Orskov H, Ledet T. Effect of growth hormone on steroidogenesis, insulin-like growth factor-I (IGF-I) and IGF-binding protein-1 production and DNA synthesis in cultured human luteinized granulosa cells. J Endocrinol. 1994 Feb;140(2):313-9. de Boer JA, Schoemaker J, van der Veen EA. Impaired reproductive function in women treated for growth hormone deficiency during childhood. Clin Endocrinol (Oxf). 1997 Jun;46(6):681-9.
  • Hsu CJ, Hammond JM. Concomitant effects of growth hormone on secretion of insulin-like growth factor I and progesterone by cultured porcine granulosa cells. Endocrinology. 1987 Oct;121(4):1343-8.
  • Erickson GF, Garzo VG, Magoffin DA. Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab. 1989 Oct;69(4):716-24.
  • Mendoza C, Cremades N, Ruiz-Requena E, Martinez F, Ortega E, Bernabeu S, Tesarik J. Relationship between fertilization results after intracytoplasmic sperm 127
There are 7 citations in total.

Details

Primary Language English
Journal Section Clinical Sciences
Authors

Kübra Boynukalın

Tolga Güler This is me

Publication Date March 4, 2014
Published in Issue Year 2013

Cite

APA Boynukalın, K., & Güler, T. (2014). The use of growth hormone in in vitro fertilization. Basic and Clinical Sciences, 2(3), 123-127. https://doi.org/10.12808/bcs.v2i3.35
AMA Boynukalın K, Güler T. The use of growth hormone in in vitro fertilization. Basic and Clinical Sciences. March 2014;2(3):123-127. doi:10.12808/bcs.v2i3.35
Chicago Boynukalın, Kübra, and Tolga Güler. “The Use of Growth Hormone in in Vitro Fertilization”. Basic and Clinical Sciences 2, no. 3 (March 2014): 123-27. https://doi.org/10.12808/bcs.v2i3.35.
EndNote Boynukalın K, Güler T (March 1, 2014) The use of growth hormone in in vitro fertilization. Basic and Clinical Sciences 2 3 123–127.
IEEE K. Boynukalın and T. Güler, “The use of growth hormone in in vitro fertilization”, Basic and Clinical Sciences, vol. 2, no. 3, pp. 123–127, 2014, doi: 10.12808/bcs.v2i3.35.
ISNAD Boynukalın, Kübra - Güler, Tolga. “The Use of Growth Hormone in in Vitro Fertilization”. Basic and Clinical Sciences 2/3 (March 2014), 123-127. https://doi.org/10.12808/bcs.v2i3.35.
JAMA Boynukalın K, Güler T. The use of growth hormone in in vitro fertilization. Basic and Clinical Sciences. 2014;2:123–127.
MLA Boynukalın, Kübra and Tolga Güler. “The Use of Growth Hormone in in Vitro Fertilization”. Basic and Clinical Sciences, vol. 2, no. 3, 2014, pp. 123-7, doi:10.12808/bcs.v2i3.35.
Vancouver Boynukalın K, Güler T. The use of growth hormone in in vitro fertilization. Basic and Clinical Sciences. 2014;2(3):123-7.