Status of hepatitis C virus infection in lung cancer patients

Year 2010, Volume: 1 Issue: 2, 39 - 44, 05.04.2013

Sulhattin Arslan Neslihan Taş İbrahim Akkurt

https://doi.org/10.12808/bcs.v1i2.8

Abstract

Abstract

Aim. The aim of this study was to evaluate the association between HCV and lung cancer. Methods. The study included 60 patients who admitted department of chest diseases our hospital for diagnosis of lung cancer. These patients were performed the blood test for HCV before to invasive procedures. Results: Of 60 patients included in this study, 58 (96.7%) were male and 2 (3.3%) were female. There was a statistically no significant difference between patients with Anti-HCV (+) and Anti-HCV (-) for gender and age (p>0.05). We found that anti-HCV antibodies were positive in 3 of 60 (5%) patients with lung cancer. Histologic types of lung cancer were 38.0 % squamous cell cancer, 30.0 % adenocarcinoma, 10.0% undifferentiated, and 21.7% small cell lung cancer. There was a statistically non-significant difference between patients with anti-HCV (+) and anti-HCV (-) for histological type of lung cancer (p>0.05). Conclusions: The development of lung cancer is a multifactorial process, including the environment factors, smoking, certain occupations, and genetic factors. HCV positivity alone may not be sufficient evidence for cause lung cancer. Therefore, there is a need studies that have large numbers of patients with HCV infection and lung cancer patients for this association.

Keywords: Lung cancer, hepatitis C virus

Özet

Akciğer kanserli hastalarda hepatit C virüs enfeksiyonun yeri

Amaç: Bu çalışmanın amacı akciğer kanseri ile Hepatit C virüsü arasındaki ilişkiyi incelemektir. Yöntem: Hastanemiz göğüs hastalıkları bölümüne akciğer kanseri ön tanısıyla başvuran 60 hasta çalışmaya alındı. Hastalara tanısal invaziv girişimler yapmadan önce hepatit C için kan örnekleri alındı. Bulgular: Çalışmaya dahil edilen 60 hastanın 58'i (%96.7) erkek, 2'si (%3.3) kadındı. Altmış hastanın 3'ü (%5) anti HCV (+) idi. Anti-HCV (+) ve anti-HCV (-) gruplar arasında yaş ve cinsiyet bakımından anlamlı bir fark yoktu (p>0.05). Akciğer kanserli hastaların histolojik tipi olarak %38.0'ı squamöz hücreli kanser, % 30.0'ı adenokarsinoma, %10.0'ı tiplendirilemeyen ve % 21.7'si küçük hücreli akciğer kanseri idi. Anti-HCV (+) ve anti-HCV (-) gruplar arasında akciğer kanserinin histolojik tipi bakımından anlamlı bir fark yoktu (p>0.05). Sonuçlar: HCV pozitifliği akciğer kanserinin nedeni olarak göstermek için yeterli kanıt olmayabilir. Akciğer kanserinin gelişmesinde sigara, bazı meslekler, çevresel ve genetik faktörleri içeren multifaktöryel etkenler rol oynamaktadır.  Akciğer kanseri ile HCV infeksiyonu arasındaki ilişki değerlendirmek için ileride daha geniş serili çalışmalara ihtiyaç vardır.

Anahtar sözcükler: Akciğer kanseri, hepatit C virüsü

Keywords

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