Abstract
Abstract
The aim of this study was to investigate the effect of cigarette smoking on intrauterine insemination (IUI) outcome in men with normal sperm concentrations. Semen samples were obtained from smoker (n=120) and non-smoker (n=125) IUI couples in our center. Semen analysis were performed manually according to WHO guidelines and Kruger's strict criteria. We found that the quality of sperm parameters in the smoker men was not significantly different than that of the nonsmoker men (p>0.05) except for ratios of chromatin condensation and progressive motility (p<0.05). Pregnancy rate of the smoker group was significantly lower than that of the nonsmoker group (p<0.001). In conclusion, smoking cigarette has a negative effect on chance of conceiving after IUI in couples with smoking male partners.
Keywords: Infertility, sperm parameters, intrauterine insemination, pregnancy rate
ÖzetBu çalışmada sperm konsantrasyonları normal olan erkeklerde, sigara içmenin intrauterin inseminasyon (İUİ) başarısı üzerindeki etkisi incelendi. Semen örnekleri sigara kullanan (n=120) ve kullanmayan (n=125) İUİ hastalarından sağlandı. Semen analizi WHO önerileri ve Kruger kriterlerine göre manuel olarak yapıldı. Kromatin kondensasyon ve progresif motil spermatozoa yüzdesi (p<0.05) haricindeki sperm parametreleri, sigara içen ve içmeyen erkekler arasında benzer bulundu (p<0.05). Gebelik oranı ise, sigara içen grupta sigara içmeyenlere göre anlamlı olarak düşük izlendi (p<0.001). Sonuç olarak, eşin sigara içmesi İUİ yapılan kadınlarda gebelik şansı üzerine olumsuz etki göstermektedir.
Anahtar sözcükler: Kısırlık, sperm parametreleri, intrauterine inseminasyon, gebelik oranı
References
- Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke: Established List. Available at: http://www.fda.gov/TobaccoProducts/GuidanceComplianceRegulatoryInformation /ucm297786.htm (Accessed January 2013).
- Zavos PM, Correa JR, Karagounis CS, Ahparaki A, Phoroglou C, Hicks CL, Zarmakoupis- Zavos PN. An electron microscope study of the axonemal ultrastructure in human spermatozoa from male smokers and nonsmokers. Fertil Steril. 1998b;69:430-434.
- ASRM. Infertility and Smoking Cessation. Available at: http://www.asrm.org/InfertilityandSmoking/ (Accessed January 2013).
- Collodel G, Capitani S, Pammolli A, Giannerini V, Geminiani M, Moretti E. Semen quality of male idiopathic infertile smokers and nonsmokers: an ultrastructural study. J Androl. 2010 Mar-Apr;31(2):108-13. doi: 10.2164/jandrol.109.007773.
- Zavos P, Correa J, Antypas S, Zarmakoupis-Zavos P, Costantinos N. Effects of seminal plasma from cigarette smokers on sperm viability and longevity. Fertil Steril. 1998a;69:425-429.
- Potts RJ, Newbury CJ, Smith G, Notarianni LJ, Jefferies TM. Sperm chromatin damage associated with male smoking. Mutat Res 1999; 423:103-111.
- Agarwal A, Said T. Role of sperm chromatin abnormalities and DNA damage in male infertility. Human Reprod Update 2003; 9:331-345.
- Alvarez J G. DNA fragmentation in human spermatozoa: significance in the diagnosis and treatment of infertility. Minerva Ginecol 2003; 55:233-239.
- Saleh R, Agarwal A, Sharma R, Nelson D, Tomas AJ. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril 2002; 78:491-499.
- Sun JG, Jurusucova A, Casper RF. Deletion of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol Reprod 1997; 56: 60260
- Aitken R, Buckingham D, Brindle J, Gomez E, Baker G, Irvine S. Analysis of sperm movement in relation to the oxidative stress created by leucocytes in washed sperm preparations and seminal plasma. Hum Reprod1995; 10: 2061-2071.
- Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN. Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res1996; 351: 199-20
Abstract
Bu çalışmada sperm konsantrasyonları normal olan erkeklerde, sigara içmenin intrauterin inseminasyon (İUİ) başarısı üzerindeki etkisi incelendi. Semen örnekleri sigara kullanan (n=120) ve kullanmayan (n=125) İUİ hastalarından sağlandı. Semen analizi WHO önerileri ve Kruger kriterlerine göre manuel olarak yapıldı. Kromatin kondensasyon ve progresif motil spermatozoa yüzdesi (p<0.05) haricindeki sperm parametreleri, sigara içen ve içmeyen erkekler arasında benzer bulundu (p<0.05). Gebelik oranı ise, sigara içen grupta sigara içmeyenlere göre anlamlı olarak düşük izlendi (p<0.001). Sonuç olarak, eşin sigara içmesi İUİ yapılan kadınlarda gebelik şansı üzerine olumsuz etki göstermektedir.
References
- Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke: Established List. Available at: http://www.fda.gov/TobaccoProducts/GuidanceComplianceRegulatoryInformation /ucm297786.htm (Accessed January 2013).
- Zavos PM, Correa JR, Karagounis CS, Ahparaki A, Phoroglou C, Hicks CL, Zarmakoupis- Zavos PN. An electron microscope study of the axonemal ultrastructure in human spermatozoa from male smokers and nonsmokers. Fertil Steril. 1998b;69:430-434.
- ASRM. Infertility and Smoking Cessation. Available at: http://www.asrm.org/InfertilityandSmoking/ (Accessed January 2013).
- Collodel G, Capitani S, Pammolli A, Giannerini V, Geminiani M, Moretti E. Semen quality of male idiopathic infertile smokers and nonsmokers: an ultrastructural study. J Androl. 2010 Mar-Apr;31(2):108-13. doi: 10.2164/jandrol.109.007773.
- Zavos P, Correa J, Antypas S, Zarmakoupis-Zavos P, Costantinos N. Effects of seminal plasma from cigarette smokers on sperm viability and longevity. Fertil Steril. 1998a;69:425-429.
- Potts RJ, Newbury CJ, Smith G, Notarianni LJ, Jefferies TM. Sperm chromatin damage associated with male smoking. Mutat Res 1999; 423:103-111.
- Agarwal A, Said T. Role of sperm chromatin abnormalities and DNA damage in male infertility. Human Reprod Update 2003; 9:331-345.
- Alvarez J G. DNA fragmentation in human spermatozoa: significance in the diagnosis and treatment of infertility. Minerva Ginecol 2003; 55:233-239.
- Saleh R, Agarwal A, Sharma R, Nelson D, Tomas AJ. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril 2002; 78:491-499.
- Sun JG, Jurusucova A, Casper RF. Deletion of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol Reprod 1997; 56: 60260
- Aitken R, Buckingham D, Brindle J, Gomez E, Baker G, Irvine S. Analysis of sperm movement in relation to the oxidative stress created by leucocytes in washed sperm preparations and seminal plasma. Hum Reprod1995; 10: 2061-2071.
- Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN. Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res1996; 351: 199-20
Details
| Primary Language | English |
|---|---|
| Journal Section | Clinical Sciences |
| Authors | |
| Publication Date | April 5, 2013 |
| Published in Issue | Year 2013 Volume: 2 Issue: 1 |