Koyunlarda Myostatin Geni ve Önemi

Abstract

İnsan beslenmesinde bitkisel ve hayvansal proteinlerin çok önemli bir yeri vardır. Dolayısıyla, bu proteinler bakımından zengin besinlerin yeterli ve dengeli miktarda alınması gereklidir. Hayvansal proteinlerin alınması bakımından et tüketilmesi ve etin de üretim miktarı ve kalitesinin artırılması önem taşımaktadır. Özellikle son zamanlarda et verimi ve kalitesi üzerine yoğunlaşan çalışmalar neticesinde bazı genler belirlenmiştir. Bunlardan biri de çift kaslılığa neden olan myostatin genidir. Bu derlemede, koyunlarda myostatin geni ve bu genin et verimi ve kalitesine etkisi hakkında bilgi verilmiştir.

Keywords

• Et,koyun,myostatin,verim

Myostatin Gene and Importance in Sheep

Abstract

    Vegetable and animal proteins have a very important place in human nutrition. Consequently, it is necessary to take adequate and balanced amounts of nutrients which are rich in these proteins. It is important to consume meat for the intake of animal proteins and increasing the production quantity and quality of the meat. Especially recently, some genes have been determined as a result of studies focusing on meat yield and quality. One of them is the myostatin gene which causes double muscling. In this review, information is given about the myostatin gene in sheep and the effect of this gene on the yield and quality of meat.

Keywords

• Meat,myostatin,production,sheep

References

1. Akçapınar, H. (2000). Koyun Yetiştiriciliği. İsmet Matbaacılık. ISBN: 975-96978-1-5, Ankara.
2. Akçapınar, H., Özbeyaz, C. (1999). Hayvan Yetiştiriciliği Temel Bilgileri. Kariyer Matbaacılık. ISBN: 975-96978-0-7, Ankara.
3. Anonim, (2015a). Charollais Koyunu. ErişimAdresi: www.hayvanbilgisi.com/koyunyetistiriciliği Erişim Tarihi: 09.12.2017.
4. Anonim, (2015b). Baluki Koyunu. Erişim Adresi: http: www.tdk.gov.tr Erişim Tarihi: 09.12.2017.
5. Ansary, M., Tahmoorespur, M., Nassiry, M. R., Taheri, A., Vafaye Valleh, M. (2011). Polymorphism in Intron-I of Myostatin gene and its association with estimated breeding values of growth traits in Baluchi sheep (Ovis aries). Indian Journal of Animal Sciences, 81 (8): 75-100.
6. Archibald, A. L., Imlah, P. (1985). The halothane sensitivity locus and its linkage relationships. Animal Blood Groups and Biochemical Genetics, 16: 253-263.
7. Arthur, P. F. (1995). Double muscling in cattle: a review. Australian Journal of Agricultural Research, 46: 1493-1515.
8. Banks, R. (1997). The Meat Elite Project: establishment and achievements of an elite meat sheep nucleus.Adv. Anim. Breed. Genet., 12.

9. Bellinge, R. H. S., Liberles, D. A., Laschi, S. P. A., Brien, O., Tay, G. K. (2005). Myostatin and its implications on animal breeding: a review. International Society for Animal Genetics, 36: 1-6.
10. Boman, I. A, Klemetsdal, G., Blichfeldt, T., Nafstad, O., Vage, D. I. (2009). A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis Aries). Animal Genetics, 40: 418-422.
11. Boman, I. A., Klemetsdal, G., Blichfeldt, T., Nafstad, O., Vage, D. I. (2010): Impact of two myostatin (MSTN) mutations on weight gain and lamb carcass classification in Norwegian White Sheep (Ovis aries). Genetics Selection Evolution, 42: 4.
12. Broad, T. E., Glass, B. C., Greer, G. J., Robertson, T. M., Bain, W. E., Lord, E. A., Mcewan, J. C. (2000). Search for a locus near to myostatin that increases muscling in Texel sheep in New Zealand. Proceedings of New Zealand Society of Animal Production, 60: 110-2.
13. Casas, E., Bennett, G. L., Smith, T. P. L., Cundiff, L. V. (2004). Association of myostatin on early calf mortality, growth, and carcass composition traits in crossbred cattle. Journal of Animal Science, 82: 2913-2918.
14. Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibe, B., Bouix, J., Caiment, F., Elsen, J. M., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, C., Georges, M. (2006). A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nature Genetics, 38: 813-818.
15. Cockett, N. E., Jackson, S. P., Green, R. D., Shay, T. L., George, M. (1993). Identification of genetic markers for and the location of a gene (callipyge) causing muscle hypertrophy in sheep. Texas Tech Univ. Agricultural Science Technology Representative, T-5-327, 4-6.
16. Eikje, E. D. (1976). Sauerasar. Forelesingsnotat Institutt for husdyravl, Ås-NLH.
17. Farhadian, M., Hashemi, A., Mardani, K., Darvishzadeh, R., Jafari, S. (2012). Polymorphisms in the ovine myostatin gene are associated with birth weight but not with weight gain in Iranian Makoei sheep. Genet Mol Res. 11 (4): 3568-75.
18. Grobet, L., Poncelet, D., Royo, L. J., Brouwers, B., Pirottin, D., Michaux, C., Menissier, F., Zanotti, M., Georges, M. (1998). Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double muscling in cattle. Mammalian Genome, 9: 210-213.
19. Hadjipavlou, G., Matika, O., Clop, A., Bishop, S. C. (2008). Two single nucleotide polymorphisms in the myostatin (GDF-8) gene have significant association with muscle depth of commercial charollais sheep. Animal Genetics, 39: 346-353.
20. Han, J., Zhou, H., Forrest, R. H., Sedcole, J. R., Frampton, C. M., Hickford, J. G. H. (2010). Effect of myostatin (MSTN) g+6223G>A on production and carcass traits in New Zealand Romney sheep. Asian-Aust. Journal of Animal Science, 23 (7): 863-866.
21. Hanset, R. (1991). Breeding for disease resistance in farm animals. In: CAB International, 467-78. Axford, Wallingford, UK.
22. Hanset, R., Michaux, C. (1985a). On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed. Experimental Data. Genetics Selection Evolution, 17 (3): 359-368.
23. Hanset, R., Michaux, C. (1985b). On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed. Population Data. Genetics Selection Evolution, 17 (3): 369-386.
24. Hickford, J. G., Forrest, R. H., Zhou, H., Fang, Q., Han, J., Frampton, C. M., Horrell, A. L. (2010). Polymorphisms in the ovine myostatin gene (MSTN) and their association with growth and carcass traits in New Zealand Romney sheep. Anim Genet. 41 (1): 64-72.
25. Johnson, P. L., Dodds, K. G., Bain, W. E., Greer, G. J., Mclean, N. J., Mclaren, R. J., Galloway, S. M., Van Stijn, T. C., Mcewan, J. C. (2009). Investigations into the GDF8 g+6273 G-A polymorphism in New Zealand Texel sheep. Journal of Animal Science, 87: 1856-1864.
26. Johnson, P. L., Mcewan, J. C., Dodds, K. G., Purchas, R. W., Blair, H. T. (2005). A directed search in the region of GDF8 for quantitative trait loci affecting carcass traits in Texel sheep. Journal of Animal Science, 83: 1988-2000.
27. Karim, L., Coppieters, W., Grobet, L., Valentini, A., Georges, M. (2000). Convenient genotyping of six myostatin mutations causing double muscling in cattle using multiplex oligonucleotide ligation assay. Animal Genetics, 3: 396-399.
28. Kawabata, M., Miyazono, K. (1999). Signal transduction of the TGF-b superfamily by smad proteins. Journal of Biochemistry, 125: 9-16.
29. Kijas, J. W., Mcculloch, R., Edwards, J. E., Oddy, V. H., Lee, S. H., Van Der Werf, J. (2007). Evidence for multiple alleles effecting muscling and fatness at the Ovine GDF8 Locus. BMC Genetics, 8: 80-90.
30. Kioumarsi, H., Jafari Khorshidi, K., Zahedifar, M., Seidavi, A. R., Rahman, W. A., Mirhosseini, S. Z., Yahaya, Z. S. (2008). Estimation of relationships between components of carcass quality and quantity in Taleshi lambs. Asia Journal of Animal and Veterinary Advances, 3: 337-343.
31. Kobolak, J., Gocza, E. (2002). The role of the myostatin protein in meat quality review. Archive Fur Tierzucht, 45: 159-170.
32. Kronacher, C. (1934). Genetik und Tierzuchtung. Handbuch der Vererbungwissenschaft, 3: 139.
33. Le Roy, P., Naveau, J., Elsen, J. M., Sellier, P. (1990). Evidence for a new major gene influencing meat quality in pigs. Genetic Research Cambridge, 55: 33-40.
34. Marcq, F., Larzul, C., Marot, V., Bouix, J., Eychenne, F., Laville, E., Georges, M., Bibe, B., Leroy, P. L., Elsen, J. M. (2002). Preliminary results of a whole genome scan targeting QTL for carcass traits in a Texel Romanov intercross. Proceedings of the 7th World Congress on Applied Livestock Production, Montpellier, 19-23 August, France, Abstract 02-14.
35. Masri, A. Y., Lambe, N. R., Macfarlane, J. M., Brotherstone, S., Haresign, W., Bunger, L. (2011). Evaluating the effects of the c*1232G>A mutation and TM-QTL in Texel x Welsh Mountain lambs using ultrasound and video image analyses. Small Rumin. Res., 99: 99-109.
36. McPherron, A. C., Lawler, A. M., Lee, S. J. (1997). Regulation of skeletal muscle mass in mice by a new TGF-B superfamily member. Nature, 387: 83-90.
37. McRae, A. F., Bishop, S. C., Walling, G. A., Wilson, A. D., Visscher, P. M. (2005). Mapping of multiple quantitative trait loci for growth and carcass traits in a complex commercial sheep pedigree. Animal Science, 80: 135-41.
38. Öz, A. (2009). Yerli Sığır ırklarında miyostatin gen polimorfizminin araştırılması. Yüksek Lisans Tezi, Çukurova Üniversitesi Fen Bilimleri Enstitüsü. Adana.
39. Ren, H., Li L., Su, H., Xu, L., Wei, C., Zhang, L., Li, H., Liu, W., Du, L. (2011). Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep. BMC Genomics. 14: 411.
40. Sopena Quesada, A., Blanco Cachafeiro, M. E. (1971). Reproduction de la femmelle culardeen race Asturienne. Annales de Génétique et de Sélection Animale, 4: 13.
41. Tahmoorespur, M., Taheri, A., Gholami, H., Ansary, M. (2011). PCR-SSCP variation of gh and stat 5a genes and their association with estimated breeding values of growth traits in baluchi sheep. Animal Biotechnology, 22: 37–43.
42. Ünal, N., Yakan, A. (2008). Bafra (Sakız x Karayaka G1) kuzularında farklı kesim ağırlıklarında besi performansı, kesim, karkas ve bazı et kalite özellikleri. TÜBİTAK Projesi. Proje no: 106058. Ankara.
43. Walling, G. A., Visscher, P. M., Wilson, A. D., Mcteir, B. L., Simm, G., Bishop, S. C. (2004). Mapping of quantitative trait loci for growth and carcass traits in commercial sheep populations. Journal of Animal Science, 82: 2234-45.
44. Wang, J., Zhou, H., Hu, J., Li, S, Luo, Y., Hickford, J. G. (2016). Two single nucleotide polymorphisms in the promoter of the ovine myostatin gene (MSTN) and their effect on growth and carcass muscle traits in New Zealand Romney sheep. J Anim Breed Genet. 133 (3): 219-26.
45. Wriedt, C. (1929). Die Vererbung des Doppellender-Kharacters die Rindern. Zeitsc hrift fuer Induktive Abstammungs und Verebungslehre, 51: 482-6.
46. Xing, H. J., Wang, Z. Y., Zhong, B. S., Ying, S. J., Nie, H. T., Zhou, Z. R., Fan, Y. X., Wang, F. (2014). Effects of different dietary intake on mRNA levels of MSTN, IGF-I, and IGF-II in the skeletal muscle of Dorper and Hu sheep hybrid F1 rams. Genet Mol Res. 13 (3): 5258-68.