İneklerde Vitamin A, D ve E’nin Fertilite Üzerine Etkisi: Derleme
Year 2025,
Volume: 14 Issue: 1, 28 - 43, 30.06.2025
Enes Çerçi
,
Mustafa Kemal Sarıbay
,
Gökhan Uyanık
Abstract
İneklerde vitamin A, D ve E takviyeleri, üreme sağlığını desteklemek, doğum sonrası enfeksiyonları önlemek ve fertiliteyi artırmak açısından kritik bir öneme sahiptir. Doğum öncesi ve sonrası dönemlerde yapılan uygun doz ve zamanlamadaki takviyeler, retensiyo sekundinarum ve metritis gibi enfeksiyonların sıklığını azaltırken, postpartum ilk östrüs süresini kısaltmakta ve gebelik oranlarını iyileştirmektedir. Vitamin A, üreme fonksiyonlarında ve bağışıklık sisteminde destekleyici bir rol üstlenirken, D vitamini kalsiyum dengesini koruyarak kemik mineralizasyonuna katkıda bulunmaktadır. E vitamini, güçlü antioksidan özellikleriyle hücre zarlarını koruyarak bağışıklık sistemini destekler. Bu vitaminlerin doğru bir şekilde uygulanması, ineklerde doğum sonrası toparlanmayı hızlandırmak ve genel sağlık durumunu iyileştirmek için etkili bir stratejidir. Bu nedenle bu vitaminlerin kullanımı ile ilgili veteriner hekimlerin güncel detaylı bilgilere ulaşması büyük bir önem arz etmektedir. Sunulan derlemede saha uygulamalarında yaygın olarak kullanılan A, D ve E vitaminlerinin fertilite üzerindeki etkileri ve uygulama stratejileri ile ilgili güncel bilgilere yer verilmeye çalışılmıştır.
References
-
Abay, M., Bekyürek, T. (2010). Effectiveness of two different GnRH analogues with or without beta-carotene and vitamin E supplementation in ovsynch protocol in Heifers. 14th Annual Conference of the European Societies Domestic Animals Reproduction, 45(3), 84, Hungary.
-
Agarwal, A., Allamaneni, S.S. (2004). Role of free radicals in female reproductive diseases and assisted reproduction. Reproductive biomedicine online, 9(3), 338-347, https://doi.org/10.1016/S1472-6483(10)62151-7
-
Aksoy, A., Daş, Y.K. (2012). Vitaminlerin Veteriner Sağaltımda Kullanımı. Turkiye Klinikleri J Vet Sci, 3(3), 65-76.
-
Allison, R. D., Laven, R. A. (2000). Effect of vitamin E supplementation on the health and fertility of dairy cows: a review. Veterinary Record, 147(25), 703-708, https://doi.org/10.1136/vr.147.25.703
-
Altıner, A., Atalay, H., Bilal, T. (2017). Bir antioksidan olarak E vitamini. Balıkesir Sağlık Bilimleri Dergisi, 6(3), 149-157, https://dx.doi.org/10.5505/bsbd.2017.47450
-
Amengual, J., Golczak, M., Palczewski, K., Von Lintig, J. (2012). Lecithin: retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. Journal of Biological Chemistry, 287(29), 24216-24227.
-
Arechiga, C. F., Vazquez-Flores, S., Ortiz, O., Hernandez-Ceron, J., Porras, A., McDowell, L. R., Hansen, P. J. (1998). Effect of injection of β-carotene or vitamin E and selenium on fertility of lactating dairy cows. Theriogenology, 50(1), 65-76, https://doi.org/10.1016/S0093-691X(98)00114-9
-
Azzi, A., Ricciarelli, R., Zingg, J. M. (2002). Non-antioxidant molecular functions of α-tocopherol (vitamin E). FEBS letters, 519(1-3), 8-10, https://doi.org/10.1016/S0014-5793(02)02706-0
-
Balamurugan, B., Ramamoorthy, M., Mandal, R. S. K., Keerthana, J., Gopalakrishnan, G., Kavya, K., Katiyar, R. (2017). Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, 6(1), 694-701.
-
Belorusova, A. Y., Rochel, N. (2016). Structural studies of vitamin D nuclear receptor ligand-binding properties. Vitamins & Hormones, 100, 83-116, https://doi.org/10.1016/bs.vh.2015.10.003
-
Bentes, C. M., Resende, M., Miranda, H., Netto, C. C., & Marinheiro, L. P. (2018). Can Vitamin D supplementation alone effective to increase a physical fitness levels in post-menopausal women with metabolic disorders? Brief Review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(1), 65-68. https://doi.org/10.1016/j.dsx.2017.08.010
-
Bilgiç, S., Aktaş, İ. (2023). Antioksidan İçeren Besinler 3. Cilt. İksad Yayınevi, Ankara, https://doi.org/10.5281/zenodo.10207212
-
Bindari, Y. R., Shrestha, S., Shrestha, N., Gaire, T. N. (2013). Effects of nutrition on reproduction-A review. Advances in Applied Science Research, 4(1), 421-429.
-
Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Martinez, N., Lima, F. S., Staples, C. R., Santos, J. E. P. (2018). Influences of nutrition and metabolism on fertility of dairy cows. Animal Reproduction (AR), 9(3), 260-272.
-
Bonrath, W., Gao, B., Houston, P., McClymont, T., Müller, M. A., Schäfer, C., Medlock, J. A. (2023). 75 years of vitamin A production: a historical and scientific overview of the development of new methodologies in chemistry, formulation, and biotechnology. Organic Process Research & Development, 27(9), 1557-1584, https://doi.org/10.1021/acs.oprd.3c00161
-
Brzezinska-Slebodzinska, E., Miller, J. K., Quigley III, J. D., Moore, J. R., Madsen, F. C. (1994). Antioxidant status of dairy cows supplemented prepartum with vitamin E and selenium. Journal of Dairy Science, 77(10), 3087-3095, https://doi.org/10.3168/jds.S0022-0302(94)77251-9
-
Campbell, M. H., Miller, J. K. (1998). Effect of supplemental dietary vitamin E and zinc on reproductive performance of dairy cows and heifers fed excess iron. Journal of dairy science, 81(10), 2693-2699, https://doi.org/10.3168/jds.S0022-0302(98)75826-6
-
Cemeroğlu, B.S., Karadeniz, F., Özkan, M. (2003). Meyve ve Sebze İşleme Teknolojisi. Gıda Teknolojisi Derneği Yayınları, 28, 541, Ankara.
-
Chew, B.P. (1995). Antioxidant vitamins affect food animal immunity and health. Journal of Nutrition, 125: 1804-1808, https://doi.org/10.1093/jn/125.suppl_6.1804S
-
Chew, B.P. (1993). Effects of supplemental β-carotene and vitamin A on reproduction in swine. J Anim Sci, 71(1): 247-252, https://doi.org/10.2527/1993.711247x
-
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., Carmeliet, G. (2016). Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological reviews, 96(1), 365-408, https://doi.org/10.1152/physrev.00014.2015
-
Cleal, J. K., Hargreaves, M. R., Poore, K. R., Tang, J. C., Fraser, W. D., Hanson, M. A., Green, L. R. (2017). Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep. Journal of developmental origins of health and disease, 8(3), 370-381, https://doi.org/10.1017/S2040174417000149
-
Coelho, M. B. (1991). Functions of vitamin E. Vitamin E in Animal Nutrition and Management, 11-17.
Colotta, F., Jansson, B., Bonelli, F. (2017). Modulation of inflammatory and immune responses by vitamin D. Journal of autoimmunity, 85, 78-97, https://doi.org/10.1016/j.jaut.2017.07.007
-
Cornell, L., Arita, K., Goodrich, R. (2020). Fat-Soluble Vitamins: A, E, and K. In: Pitchumoni, C.S., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-90761-1_22-1
-
Das, S., Chattopadhyay, R., Ghosh, S., Ghosh, S., Goswami, S. K., Chakravarty, B. N., Chaudhury, K. (2006). Reactive oxygen species level in follicular fluid—embryo quality marker in IVF?. Human reproduction, 21(9), 2403-2407, https://doi.org/10.1093/humrep/del156
-
Daşkın, A. (2005). Sığırcılık İşletmelerinde Reprodüksiyon Yönetimi ve Suni Tohumlama Kitabı, 226-244, Uğurer Tarım Yayınevi, Ankara.
-
Debski, B., Nowicki, T., Zalewski, W., Ochota, M., Mrowiec, J., Twardon, J. (2016). Evaluation of acute phase proteins in clinically healthy dairy cows in perinatal period and during lactation. Pol. J. Vet. Sci., 19:519–523, https://doi.org/10.1515/pjvs-2016-0065
-
Erskine, R. J., Bartlett, P. C., Herdt, T., Gaston, P. (1997). Effects of parenteral administration of vitamin E on health of periparturient dairy cows. Journal of the American Veterinary Medical Association, 211(4), 466-469, https://doi.org/10.2460/javma.1997.211.04.466
-
Faisel, H., Pittrof, R. (2000). Vitamin A and causes of maternal mortality: association and biological plausibility. Public Health Nutrition, 3(3), 321-327, https://doi.org/10.1017/S1368980000000367
-
Garcia, M., Seelaender, M., Sotiropoulos, A., Coletti, D., Lancha Jr, A. H. (2019). Vitamin D, muscle recovery, sarcopenia, cachexia, and muscle atrophy. Nutrition, 60, 66-69, https://doi.org/10.1016/j.nut.2018.09.031
-
Glynn, R. J., Ridker, P. M., Goldhaber, S. Z., Zee, R. Y., Buring, J. E. (2007). Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women’s Health Study. Circulation, 116(13), 1497-1503, https://doi.org/10.1161/CIRCULATIONAHA.107.716407
-
Goff, J. P. (2008). The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. The veterinary journal, 176(1), 50-57, https://doi.org/10.1016/j.tvjl.2007.12.020
-
Grilo, E. C., Medeiros, W. F., Silva, A. G. A., Gurgel, C. S. S., Ramalho, H. M. M., Dimenstein, R. (2016). Maternal supplementation with a megadose of vitamin A reduces colostrum level of α‐tocopherol: a randomised controlled trial. Journal of human nutrition and dietetics, 29(5), 652-661, https://doi.org/10.1111/jhn.12381
-
Grundmann, M., von Versen-Höynck, F. (2011). Vitamin D-roles in women's reproductive health?. Reproductive biology and endocrinology, 9, 1-12, https://doi.org/10.1186/1477-7827-9-146
-
Gunville, C. F., Mourani, P. M., Ginde, A. A. (2013) The role of vitamin D in prevention and treatment of infection. Inflamm. Allergy Drug Targets, 12, 239-245.
-
Hafez, E.S.E., Hafez, B. (2000). Reproduction in Farm Animals. Editors: Hafez ESE, Hafez B. In: Reproductive Cycles. 7th Ed., Wiley-Blackwell, Oxford, 55-67.
-
Haliloglu, S., Baspinar, N., Serpek, B., Erdem, H., Bulut, Z. (2002). Vitamin A and β‐carotene levels in plasma, corpus luteum and follicular fluid of cyclic and pregnant cattle. Reproduction in Domestic Animals, 37(2), 96-99, https://doi.org/10.1046/j.1439-0531.2002.00338.x
-
Hammon, D., Evjen, I. M., Dhiman, T. R., Goff, J. P., Walters, J. L. (2006). Neutrophil function and energy status in Holstein cows with uterine health disorders. Veterinary immunology and immunopathology, 113(1-2), 21-29, https://doi.org/10.1016/j.vetimm.2006.03.022
-
Hayırlı, A., Çolak, A. (2011). İneklerin kuru ve geçiş dönemlerinde sevk-idare ve besleme stratejileri: postpartum süreçte metabolik profil, sağlık durumu ve fertiliteye etkisi. Turkiye Klinikleri Journal of Veterinary Science, 2, 1-35.
-
Heaney, R. P., Armas, L. A. (2015). Quantifying the vitamin D economy. Nutrition Reviews, 73, 51-67, https://doi.org/10.1093/nutrit/nuu004
-
Holcombe, S. J., Wisnieski, L., Gandy, J., Norby, B., Sordillo, L. M. (2018). Reduced serum vitamin D concentrations in healthy early-lactation dairy cattle. Journal of dairy science, 101(2), 1488-1494, https://doi.org/10.3168/jds.2017-13547
-
Holick, M. F. (2005). The vitamin D epidemic and its health consequences. The Journal of nutrition, 135(11), 2739-2748, https://doi.org/10.1093/jn/135.11.2739S
-
Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-281.
-
Horst, R. L., Goff, J. P., Renhardt, T. A. (2003). Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis. Acta Vet Scan Supp, 97, 35-50.
-
Hymøller, L., Jensen, S. K., Lindqvist, H., Johansson, B., Nielsen, M. O., Nadeau, E. (2009). Supplementing dairy steers and organically managed dairy cows with synthetic vitamin D3 is unnecessary at pasture during exposure to summer sunlight. Journal of dairy research, 76(3), 372-378, https://doi.org/10.1017/S0022029909004130
-
Hymøller, L., Jensen, S. K. (2010). Vitamin D3 synthesis in the entire skin surface of dairy cows despite hair coverage. Journal of dairy science, 93(5), 2025-2029, https://doi.org/10.3168/jds.2009-2991
-
Jakobsen, J., Jensen, S. K., Hymøller, L., Andersen, E. W., Kaas, P., Burild, A., Jäpelt, R. B. (2015). Artificial ultraviolet B light exposure increases vitamin D levels in cow plasma and milk. Journal of Dairy Science, 98(9), 6492-6498, https://doi.org/10.3168/jds.2014-9277
-
Jaskowski, J. M. (1993). The effect of antepartum doses of selenium vitamin E combinations on the incidence of puerperal disorders in cattle. Tierarztliche Praxis, 21, 111-116.
-
Kandelousi, M., Alamouti, A. A., Imani, M., Zebeli, Q. (2020). A meta-analysis and meta-regression of the effects of vitamin E supplementation on serum enrichment, udder health, milk yield, and reproductive performance of transition cows. Journal of dairy science, 103(7), 6157-6166. https://doi.org/10.3168/jds.2019-17556
-
Karabulut, H., Gülay, M. Ş. (2016). Antioksidanlar. Veterinary Journal of Mehmet Akif Ersoy University, 1(1), 65-76, https://doi.org/10.24880/maeuvfd.260790
-
Kaya, S., Bilgili, A. (1997). Veteriner Uygulamalı Farmakoloji, Editörler: Kaya, S., Pirinçci, İ., Bilgili, A. Beslenme Farmakolojisi Cilt 1-2, 217-270, Medisan Yayınevi, Ankara.
-
Kennel, K. A., Drake, M. T., Hurley, D. L. (2010). Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc, 85(8), 752-758, https://doi.org/10.4065/mcp.2010.0138
-
Khatti, A., Mehrotra, S., Patel, P. K., Singh, G., Maurya, V. P., Mahla, A. S., Krishnaswamy, N. (2017). Supplementation of vitamin E, selenium and increased energy allowance mitigates the transition stress and improves postpartum reproductive performance in the crossbred cow. Theriogenology, 104, 142-148, https://doi.org/10.1016/j.theriogenology.2017.08.014
-
Koramaz, G. (2020). Honamlı ve kıl keçi kolostrumlarındaki A, D3 ve E vitamin düzeylerinde doğumdan sonraki 5 gün süredeki değişimlerin belirlenmesi. (Doktora Tezi). Burdur Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü, Burdur.
-
Lean, I. J., Van Saun, R., Degaris, P. J. (2013). Mineral and antioxidant management of transition dairy cows. Veterinary Clinics of North America: Food Animal Practice, 29(2), 367-386.
-
Lerchbaum, E., Obermayer-Pietsch, B. (2012). Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. European journal of endocrinology, 166(5), 765-778, https://doi.org/10.1530/EJE-11-0984
-
Lewis, E. D., Meydani, S. N., Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life, 71(4), 487-494, https://doi.org/10.1002/iub.1976.
-
Lin, R. (2016). Crosstalk between vitamin D metabolism, VDR signalling, and innate immunity. BioMed research international, 2016(1), 1375858, https://doi.org/10.1155/2016/1375858
-
Lin, X., Meng, X., Song, Z. (2019). Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. American journal of translational research, 11(9), 5285.
-
Malloy, P. J., Peng, L., Wang, J., Feldman, D. (2009). Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells. Endocrinology, 150(4), 1580-1587, https://doi.org/10.1210/en.2008-1555
-
Martinez, N., Rodney, R. M., Block, E., Hernandez, L. L., Nelson, C. D., Lean, I. J., Santos, J. E. P. (2018). Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Health and reproductive responses. Journal of dairy science, 101(3), 2563-2578, https://doi.org/10.3168/jds.2017-13740
-
Martinez, N., Risco, C. A., Lima, F. S., Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Santos, J. E. P. (2012). Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. Journal of dairy science, 95(12), 7158-7172, https://doi.org/10.3168/jds.2012-5812
-
McDowell, L. R. (2000). Vitamins in Animal Nutrition Comparative Aspects to Human Nutrition. Academic Press Inc, 93-131, California.
-
Mehdi, Y., Dufrasne, I. (2016). Selenium in cattle: a review. Molecules, 21(4), 545.https://doi.org/10.3390/molecules21040545
-
Merhi, Z., Doswell, A., Krebs, K., Cipolla, M. (2014). Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. The Journal of Clinical Endocrinology & Metabolism, 99(6), E1137-E1145, https://doi.org/10.1210/jc.2013-4161
-
Muscogiuri, G., Altieri, B., de Angelis, C., Palomba, S., Pivonello, R., Colao, A., Orio, F. (2017). Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders, 18, 273-283, https://doi.org/10.1007/s11154-017-9407-2
-
Nelson, C. D., Reinhardt, T. A., Beitz, D. C., Lippolis, J. D. (2010). In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection. PloS one, 5(11), e15469, https://doi.org/10.1371/journal.pone.0015469
-
Nelson, C. D., Reinhardt, T. A., Lippolis, J. D., Sacco, R. E., Nonnecke, B. J. (2012). Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements. Nutrients, 4(3), 181-196, https://doi.org/10.3390/nu4030181
-
Nelson, C. D., Merriman, K. E. (2014). Vitamin D metabolism in dairy cattle and implications for dietary requirements. In 25th Annual Florida Ruminant Nutrient Symposium, 78-90.
-
Nelson, C. D., Powell, J. L., Price, D. M., Hersom, M. J., Yelich, J. V., Drewnoski, M. E., Bridges, G. A. (2016a). Assessment of serum 25-hydroxyvitamin D concentrations of beef cows and calves across seasons and geographical locations. Journal of Animal Science, 94(9), 3958-3965, https://doi.org/10.2527/jas.2016-0611
-
Nelson, C. D., Lippolis, J. D., Reinhardt, T. A., Sacco, R. E., Powell, J. L., Drewnoski, M. E., Weiss, W. P. (2016b). Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of dairy science, 99(12), 10150-10160, https://doi.org/10.3168/jds.2016-11727
-
Öngen, B., Kabaroğlu, C., Parıldar, Z. (2008). D vitamininin biyokimyasal ve laboratuvar değerlendirmesi. Türk Klinik Biyokimya Dergisi, 6, 23-31.
-
Paffoni, A., Ferrari, S., Viganò, P., Pagliardini, L., Papaleo, E., Candiani, M., Somigliana, E. (2014). Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. The Journal of Clinical Endocrinology & Metabolism, 99(11), E2372-E2376, https://doi.org/10.1210/jc.2014-1802
-
Pontes, G. C. D. S., Monteiro Jr, P. L. J., Prata, A. B., Guardieiro, M. M., Pinto, D. A. M., Fernandes, G. O., Sartori, R. (2015). Effect of injectable vitamin E on incidence of retained fetal membranes and reproductive performance of dairy cows. Journal of dairy science, 98(4), 2437-2449, https://doi.org/10.3168/jds.2014-8886
-
Pu, Y., Wang, Z., Bian, Y., Zhang, F., Yang, P., Li, Y., Zhang, X. (2014). All‐trans retinoic acid improves goat oocyte nuclear maturation and reduces apoptotic cumulus cells during in vitro maturation. Animal Science Journal, 85(9), 833-839, https://doi.org/10.1111/asj.12216
-
Qureshi, Z. I, Siddiq, M., Lodhi, L. A., Muhammad, G., Jamil, H. (2009). Effect of vitamin E-selenium administration during late gestation on productive and reproductive performance in dairy buffaloes and on growth performance of their calves. Pakistan Veterinary Journal, 30(2), 83-86.
-
Radostits, O. M., Gay, C. C., Hinchcliff, K. W., Constable, P. D. (2007). A textbook of the diseases of cattle, horses, sheep, pigs and goats. Vet. Med, 10, 2045-2050.
-
Ribeiro, E. S., Gomes, G., Greco, L. F., Cerri, R. L. A., Vieira-Neto, A., Monteiro Jr, P. L. J., Santos, J. E. P. (2016). Carryover effect of postpartum inflammatory diseases on developmental biology and fertility in lactating dairy cows. Journal of dairy science, 99(3), 2201-2220, https://doi.org/10.3168/jds.2015-10337
-
Roche, J. R., Burke, C. R., Crookenden, M. A., Heiser, A., Loor, J. L., Meier, S., Turner, S. A. (2018). Fertility and the transition dairy cow. Reproduction, Fertility and Development, 30(1), 85-100, https://doi.org/10.1071/RD17412
-
Rode, L. M., Coulter, G. H., Kastelic, J. P., Bailey, D. R. C. (1995). Seminal quality and sperm production in beef bulls with chronic dietary vitamin A deficiency and subsequent re-alimentation. Theriogenology, 43(7), 1269-1277, https://doi.org/10.1016/0093-691X(95)00098-S
-
Shastak, Y., Obermueller-Jevic, U., Pelletier, W. (2023). A century of vitamin E: Early milestones and future directions in animal nutrition. Agriculture, 13(8), 1526, https://doi.org/10.3390/agriculture13081526
-
Sönmez, M., Bozkurt, T., Türk, G., Gür, S., Kızıl, M., Yüce, A. (2009). The effect of vitamin E treatment during preovulatory period on reproductive performance of goats following estrous synchronization using intravaginal sponges. Animal Reproduction Science, 114(1-3), 183-192, https://doi.org/10.1016/j.anireprosci.2008.09.007
-
Starič, J. (2010). Dynamics of biochemical markers of bone metabolism in dairy cows treated with high dose of vitamin D3 as prevention against periparturient hypocalcaemia. (PhD thesis). University of Ljubljana, Veterinary Faculty, Slovenia.
-
Şahin, N. (2008). Vitaminler. Hayvan Besleme ve Beslenme Hastalıkları. 85-112, Medipres, Malatya.
Trojačanec, S., Boboš, S., Pajić, M. (2012). Influence of β-carotene and vitamin A supplementation on the ovarian activity of dairy cows with chronic fertility impairment. Veterinarski Arhiv, 82(6), 567-575.
-
Tuncer, Ş. D. (2008). Hayvan Besleme ve Beslenme Hastalıkları. Ergün, A., Tuncer, Ş. D., Çolpan, İ,, Yalçın, S., Yıldız, G., Küçükersan, M. K., Küçükersan, S., Şehu, A. (Ed). Süt Sığırlarının Beslenmesi. 253-299, Ankara.
-
Turan, Ö. D. (2018). Vitamin D Level and Infertility. Meandros Med Dental J, 19(2), 106-110, https://doi.org/10.4274/meandros.2399
-
Turner, R. J., Finch, J. M. (1991). Selenium and the immune response. Proceedings of the Nutrition Society, 50(2), 275-285, https://doi.org/10.1079/PNS19910037
-
Valastyan, S., Thakur, V., Johnson, A., Kumar, K., Manor, D. (2008). Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis. Biochemistry, 47(2), 744-752, https://doi.org/10.1021/bi701432q
-
Verstuyf, A., Carmeliet, G., Bouillon, R., Mathieu, C. (2010). Vitamin D: a pleiotropic hormone. Kidney international, 78(2), 140-145, https://doi.org/10.1038/ki.2010.17
-
Xiao, J., Khan, M. Z., Ma, Y., Alugongo, G. M., Ma, J., Chen, T., Cao, Z. (2021). The antioxidant properties of selenium and vitamin E; their role in periparturient dairy cattle health regulation. Antioxidants, 10(10), 1555, https://doi.org/10.3390/antiox10101555
-
Xu, J., Lawson, M. S., Xu, F., Du, Y., Tkachenko, O. Y., Bishop, C. V., Hennebold, J. D. (2018). Vitamin D3 regulates follicular development and intrafollicular vitamin D biosynthesis and signaling in the primate ovary. Frontiers in physiology, 9, 1600, https://doi.org/10.3389/fphys.2018.01600
-
Yao, X., Wang, Z., El-Samahy, M. A., Ren, C., Liu, Z., Wang, F., You, P. (2020). Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat. Reproduction, Fertility and Development, 32(3), 335-348, https://doi.org/10.1071/RD18442
-
Yazıcıoğlu, Ö. (1994). Sığırlarda hipovitaminosis-A. Etlik Veteriner Mikrobiyoloji Dergisi, 7(5), 183-194.
Yeşil, M., Sarıözkan, S. (2017). Dişi üreme sistemi açısından önemli bazı vitamin ve mineraller. Erciyes Üniv Vet Fak Derg, 14(3), 201-208.
-
Yılmaz, N., Seven, B. (2021) Üreme Sağlığı ve D Vitamini. Turkish Journal of Reproductive Medicine and Surgery, 5(1), 36-42, https: doi.org//10.24074/tjrms.2020-80791
-
Zafalon, R. V. A., Ruberti, B., Rentas, M. F., Amaral, A. R., Vendramini, T. H. A., Chacar, F. C., Brunetto, M. A. (2020). The role of vitamin D in small animal bone metabolism. Metabolites, 10(12), 496, https://doi.org/10.3390/metabo10120496
-
Zingg, J. M. (2007). Vitamin E: an overview of major research directions. Molecular aspects of medicine, 28(5-6), 400-422, https://doi.org/10.1016/j.mam.2007.05.004
The Effect of Vitamins A, D and E on Fertility in Cows: Review
Year 2025,
Volume: 14 Issue: 1, 28 - 43, 30.06.2025
Enes Çerçi
,
Mustafa Kemal Sarıbay
,
Gökhan Uyanık
Abstract
Vitamin A, D and E supplements are critical to support reproductive health, prevent postpartum infections and increase fertility in cows. Appropriate doses and timing of supplements in the pre- and postnatal periods reduce the frequency of infections such as retensio secundinarum and metritis, shorten the duration of the first postpartum oestrus and improve pregnancy rates. Vitamin A plays a supportive role in reproductive function and the immune system, while vitamin D contributes to bone mineralisation by maintaining calcium balance. Vitamin E supports the immune system by protecting cell membranes with its powerful antioxidant properties. The correct administration of these vitamins is an effective strategy to accelerate postpartum recovery and improve overall health status in cows. Therefore, it is of great importance for veterinarians to have up-to-date detailed information on the use of these vitamins. In the present review, it has been tried to include current information on the effects of vitamins A, D and E on fertility and application strategies, which are widely used in field applications.
References
-
Abay, M., Bekyürek, T. (2010). Effectiveness of two different GnRH analogues with or without beta-carotene and vitamin E supplementation in ovsynch protocol in Heifers. 14th Annual Conference of the European Societies Domestic Animals Reproduction, 45(3), 84, Hungary.
-
Agarwal, A., Allamaneni, S.S. (2004). Role of free radicals in female reproductive diseases and assisted reproduction. Reproductive biomedicine online, 9(3), 338-347, https://doi.org/10.1016/S1472-6483(10)62151-7
-
Aksoy, A., Daş, Y.K. (2012). Vitaminlerin Veteriner Sağaltımda Kullanımı. Turkiye Klinikleri J Vet Sci, 3(3), 65-76.
-
Allison, R. D., Laven, R. A. (2000). Effect of vitamin E supplementation on the health and fertility of dairy cows: a review. Veterinary Record, 147(25), 703-708, https://doi.org/10.1136/vr.147.25.703
-
Altıner, A., Atalay, H., Bilal, T. (2017). Bir antioksidan olarak E vitamini. Balıkesir Sağlık Bilimleri Dergisi, 6(3), 149-157, https://dx.doi.org/10.5505/bsbd.2017.47450
-
Amengual, J., Golczak, M., Palczewski, K., Von Lintig, J. (2012). Lecithin: retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. Journal of Biological Chemistry, 287(29), 24216-24227.
-
Arechiga, C. F., Vazquez-Flores, S., Ortiz, O., Hernandez-Ceron, J., Porras, A., McDowell, L. R., Hansen, P. J. (1998). Effect of injection of β-carotene or vitamin E and selenium on fertility of lactating dairy cows. Theriogenology, 50(1), 65-76, https://doi.org/10.1016/S0093-691X(98)00114-9
-
Azzi, A., Ricciarelli, R., Zingg, J. M. (2002). Non-antioxidant molecular functions of α-tocopherol (vitamin E). FEBS letters, 519(1-3), 8-10, https://doi.org/10.1016/S0014-5793(02)02706-0
-
Balamurugan, B., Ramamoorthy, M., Mandal, R. S. K., Keerthana, J., Gopalakrishnan, G., Kavya, K., Katiyar, R. (2017). Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, 6(1), 694-701.
-
Belorusova, A. Y., Rochel, N. (2016). Structural studies of vitamin D nuclear receptor ligand-binding properties. Vitamins & Hormones, 100, 83-116, https://doi.org/10.1016/bs.vh.2015.10.003
-
Bentes, C. M., Resende, M., Miranda, H., Netto, C. C., & Marinheiro, L. P. (2018). Can Vitamin D supplementation alone effective to increase a physical fitness levels in post-menopausal women with metabolic disorders? Brief Review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(1), 65-68. https://doi.org/10.1016/j.dsx.2017.08.010
-
Bilgiç, S., Aktaş, İ. (2023). Antioksidan İçeren Besinler 3. Cilt. İksad Yayınevi, Ankara, https://doi.org/10.5281/zenodo.10207212
-
Bindari, Y. R., Shrestha, S., Shrestha, N., Gaire, T. N. (2013). Effects of nutrition on reproduction-A review. Advances in Applied Science Research, 4(1), 421-429.
-
Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Martinez, N., Lima, F. S., Staples, C. R., Santos, J. E. P. (2018). Influences of nutrition and metabolism on fertility of dairy cows. Animal Reproduction (AR), 9(3), 260-272.
-
Bonrath, W., Gao, B., Houston, P., McClymont, T., Müller, M. A., Schäfer, C., Medlock, J. A. (2023). 75 years of vitamin A production: a historical and scientific overview of the development of new methodologies in chemistry, formulation, and biotechnology. Organic Process Research & Development, 27(9), 1557-1584, https://doi.org/10.1021/acs.oprd.3c00161
-
Brzezinska-Slebodzinska, E., Miller, J. K., Quigley III, J. D., Moore, J. R., Madsen, F. C. (1994). Antioxidant status of dairy cows supplemented prepartum with vitamin E and selenium. Journal of Dairy Science, 77(10), 3087-3095, https://doi.org/10.3168/jds.S0022-0302(94)77251-9
-
Campbell, M. H., Miller, J. K. (1998). Effect of supplemental dietary vitamin E and zinc on reproductive performance of dairy cows and heifers fed excess iron. Journal of dairy science, 81(10), 2693-2699, https://doi.org/10.3168/jds.S0022-0302(98)75826-6
-
Cemeroğlu, B.S., Karadeniz, F., Özkan, M. (2003). Meyve ve Sebze İşleme Teknolojisi. Gıda Teknolojisi Derneği Yayınları, 28, 541, Ankara.
-
Chew, B.P. (1995). Antioxidant vitamins affect food animal immunity and health. Journal of Nutrition, 125: 1804-1808, https://doi.org/10.1093/jn/125.suppl_6.1804S
-
Chew, B.P. (1993). Effects of supplemental β-carotene and vitamin A on reproduction in swine. J Anim Sci, 71(1): 247-252, https://doi.org/10.2527/1993.711247x
-
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., Carmeliet, G. (2016). Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological reviews, 96(1), 365-408, https://doi.org/10.1152/physrev.00014.2015
-
Cleal, J. K., Hargreaves, M. R., Poore, K. R., Tang, J. C., Fraser, W. D., Hanson, M. A., Green, L. R. (2017). Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep. Journal of developmental origins of health and disease, 8(3), 370-381, https://doi.org/10.1017/S2040174417000149
-
Coelho, M. B. (1991). Functions of vitamin E. Vitamin E in Animal Nutrition and Management, 11-17.
Colotta, F., Jansson, B., Bonelli, F. (2017). Modulation of inflammatory and immune responses by vitamin D. Journal of autoimmunity, 85, 78-97, https://doi.org/10.1016/j.jaut.2017.07.007
-
Cornell, L., Arita, K., Goodrich, R. (2020). Fat-Soluble Vitamins: A, E, and K. In: Pitchumoni, C.S., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-90761-1_22-1
-
Das, S., Chattopadhyay, R., Ghosh, S., Ghosh, S., Goswami, S. K., Chakravarty, B. N., Chaudhury, K. (2006). Reactive oxygen species level in follicular fluid—embryo quality marker in IVF?. Human reproduction, 21(9), 2403-2407, https://doi.org/10.1093/humrep/del156
-
Daşkın, A. (2005). Sığırcılık İşletmelerinde Reprodüksiyon Yönetimi ve Suni Tohumlama Kitabı, 226-244, Uğurer Tarım Yayınevi, Ankara.
-
Debski, B., Nowicki, T., Zalewski, W., Ochota, M., Mrowiec, J., Twardon, J. (2016). Evaluation of acute phase proteins in clinically healthy dairy cows in perinatal period and during lactation. Pol. J. Vet. Sci., 19:519–523, https://doi.org/10.1515/pjvs-2016-0065
-
Erskine, R. J., Bartlett, P. C., Herdt, T., Gaston, P. (1997). Effects of parenteral administration of vitamin E on health of periparturient dairy cows. Journal of the American Veterinary Medical Association, 211(4), 466-469, https://doi.org/10.2460/javma.1997.211.04.466
-
Faisel, H., Pittrof, R. (2000). Vitamin A and causes of maternal mortality: association and biological plausibility. Public Health Nutrition, 3(3), 321-327, https://doi.org/10.1017/S1368980000000367
-
Garcia, M., Seelaender, M., Sotiropoulos, A., Coletti, D., Lancha Jr, A. H. (2019). Vitamin D, muscle recovery, sarcopenia, cachexia, and muscle atrophy. Nutrition, 60, 66-69, https://doi.org/10.1016/j.nut.2018.09.031
-
Glynn, R. J., Ridker, P. M., Goldhaber, S. Z., Zee, R. Y., Buring, J. E. (2007). Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women’s Health Study. Circulation, 116(13), 1497-1503, https://doi.org/10.1161/CIRCULATIONAHA.107.716407
-
Goff, J. P. (2008). The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. The veterinary journal, 176(1), 50-57, https://doi.org/10.1016/j.tvjl.2007.12.020
-
Grilo, E. C., Medeiros, W. F., Silva, A. G. A., Gurgel, C. S. S., Ramalho, H. M. M., Dimenstein, R. (2016). Maternal supplementation with a megadose of vitamin A reduces colostrum level of α‐tocopherol: a randomised controlled trial. Journal of human nutrition and dietetics, 29(5), 652-661, https://doi.org/10.1111/jhn.12381
-
Grundmann, M., von Versen-Höynck, F. (2011). Vitamin D-roles in women's reproductive health?. Reproductive biology and endocrinology, 9, 1-12, https://doi.org/10.1186/1477-7827-9-146
-
Gunville, C. F., Mourani, P. M., Ginde, A. A. (2013) The role of vitamin D in prevention and treatment of infection. Inflamm. Allergy Drug Targets, 12, 239-245.
-
Hafez, E.S.E., Hafez, B. (2000). Reproduction in Farm Animals. Editors: Hafez ESE, Hafez B. In: Reproductive Cycles. 7th Ed., Wiley-Blackwell, Oxford, 55-67.
-
Haliloglu, S., Baspinar, N., Serpek, B., Erdem, H., Bulut, Z. (2002). Vitamin A and β‐carotene levels in plasma, corpus luteum and follicular fluid of cyclic and pregnant cattle. Reproduction in Domestic Animals, 37(2), 96-99, https://doi.org/10.1046/j.1439-0531.2002.00338.x
-
Hammon, D., Evjen, I. M., Dhiman, T. R., Goff, J. P., Walters, J. L. (2006). Neutrophil function and energy status in Holstein cows with uterine health disorders. Veterinary immunology and immunopathology, 113(1-2), 21-29, https://doi.org/10.1016/j.vetimm.2006.03.022
-
Hayırlı, A., Çolak, A. (2011). İneklerin kuru ve geçiş dönemlerinde sevk-idare ve besleme stratejileri: postpartum süreçte metabolik profil, sağlık durumu ve fertiliteye etkisi. Turkiye Klinikleri Journal of Veterinary Science, 2, 1-35.
-
Heaney, R. P., Armas, L. A. (2015). Quantifying the vitamin D economy. Nutrition Reviews, 73, 51-67, https://doi.org/10.1093/nutrit/nuu004
-
Holcombe, S. J., Wisnieski, L., Gandy, J., Norby, B., Sordillo, L. M. (2018). Reduced serum vitamin D concentrations in healthy early-lactation dairy cattle. Journal of dairy science, 101(2), 1488-1494, https://doi.org/10.3168/jds.2017-13547
-
Holick, M. F. (2005). The vitamin D epidemic and its health consequences. The Journal of nutrition, 135(11), 2739-2748, https://doi.org/10.1093/jn/135.11.2739S
-
Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-281.
-
Horst, R. L., Goff, J. P., Renhardt, T. A. (2003). Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis. Acta Vet Scan Supp, 97, 35-50.
-
Hymøller, L., Jensen, S. K., Lindqvist, H., Johansson, B., Nielsen, M. O., Nadeau, E. (2009). Supplementing dairy steers and organically managed dairy cows with synthetic vitamin D3 is unnecessary at pasture during exposure to summer sunlight. Journal of dairy research, 76(3), 372-378, https://doi.org/10.1017/S0022029909004130
-
Hymøller, L., Jensen, S. K. (2010). Vitamin D3 synthesis in the entire skin surface of dairy cows despite hair coverage. Journal of dairy science, 93(5), 2025-2029, https://doi.org/10.3168/jds.2009-2991
-
Jakobsen, J., Jensen, S. K., Hymøller, L., Andersen, E. W., Kaas, P., Burild, A., Jäpelt, R. B. (2015). Artificial ultraviolet B light exposure increases vitamin D levels in cow plasma and milk. Journal of Dairy Science, 98(9), 6492-6498, https://doi.org/10.3168/jds.2014-9277
-
Jaskowski, J. M. (1993). The effect of antepartum doses of selenium vitamin E combinations on the incidence of puerperal disorders in cattle. Tierarztliche Praxis, 21, 111-116.
-
Kandelousi, M., Alamouti, A. A., Imani, M., Zebeli, Q. (2020). A meta-analysis and meta-regression of the effects of vitamin E supplementation on serum enrichment, udder health, milk yield, and reproductive performance of transition cows. Journal of dairy science, 103(7), 6157-6166. https://doi.org/10.3168/jds.2019-17556
-
Karabulut, H., Gülay, M. Ş. (2016). Antioksidanlar. Veterinary Journal of Mehmet Akif Ersoy University, 1(1), 65-76, https://doi.org/10.24880/maeuvfd.260790
-
Kaya, S., Bilgili, A. (1997). Veteriner Uygulamalı Farmakoloji, Editörler: Kaya, S., Pirinçci, İ., Bilgili, A. Beslenme Farmakolojisi Cilt 1-2, 217-270, Medisan Yayınevi, Ankara.
-
Kennel, K. A., Drake, M. T., Hurley, D. L. (2010). Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc, 85(8), 752-758, https://doi.org/10.4065/mcp.2010.0138
-
Khatti, A., Mehrotra, S., Patel, P. K., Singh, G., Maurya, V. P., Mahla, A. S., Krishnaswamy, N. (2017). Supplementation of vitamin E, selenium and increased energy allowance mitigates the transition stress and improves postpartum reproductive performance in the crossbred cow. Theriogenology, 104, 142-148, https://doi.org/10.1016/j.theriogenology.2017.08.014
-
Koramaz, G. (2020). Honamlı ve kıl keçi kolostrumlarındaki A, D3 ve E vitamin düzeylerinde doğumdan sonraki 5 gün süredeki değişimlerin belirlenmesi. (Doktora Tezi). Burdur Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü, Burdur.
-
Lean, I. J., Van Saun, R., Degaris, P. J. (2013). Mineral and antioxidant management of transition dairy cows. Veterinary Clinics of North America: Food Animal Practice, 29(2), 367-386.
-
Lerchbaum, E., Obermayer-Pietsch, B. (2012). Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. European journal of endocrinology, 166(5), 765-778, https://doi.org/10.1530/EJE-11-0984
-
Lewis, E. D., Meydani, S. N., Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life, 71(4), 487-494, https://doi.org/10.1002/iub.1976.
-
Lin, R. (2016). Crosstalk between vitamin D metabolism, VDR signalling, and innate immunity. BioMed research international, 2016(1), 1375858, https://doi.org/10.1155/2016/1375858
-
Lin, X., Meng, X., Song, Z. (2019). Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. American journal of translational research, 11(9), 5285.
-
Malloy, P. J., Peng, L., Wang, J., Feldman, D. (2009). Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells. Endocrinology, 150(4), 1580-1587, https://doi.org/10.1210/en.2008-1555
-
Martinez, N., Rodney, R. M., Block, E., Hernandez, L. L., Nelson, C. D., Lean, I. J., Santos, J. E. P. (2018). Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Health and reproductive responses. Journal of dairy science, 101(3), 2563-2578, https://doi.org/10.3168/jds.2017-13740
-
Martinez, N., Risco, C. A., Lima, F. S., Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Santos, J. E. P. (2012). Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. Journal of dairy science, 95(12), 7158-7172, https://doi.org/10.3168/jds.2012-5812
-
McDowell, L. R. (2000). Vitamins in Animal Nutrition Comparative Aspects to Human Nutrition. Academic Press Inc, 93-131, California.
-
Mehdi, Y., Dufrasne, I. (2016). Selenium in cattle: a review. Molecules, 21(4), 545.https://doi.org/10.3390/molecules21040545
-
Merhi, Z., Doswell, A., Krebs, K., Cipolla, M. (2014). Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. The Journal of Clinical Endocrinology & Metabolism, 99(6), E1137-E1145, https://doi.org/10.1210/jc.2013-4161
-
Muscogiuri, G., Altieri, B., de Angelis, C., Palomba, S., Pivonello, R., Colao, A., Orio, F. (2017). Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders, 18, 273-283, https://doi.org/10.1007/s11154-017-9407-2
-
Nelson, C. D., Reinhardt, T. A., Beitz, D. C., Lippolis, J. D. (2010). In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection. PloS one, 5(11), e15469, https://doi.org/10.1371/journal.pone.0015469
-
Nelson, C. D., Reinhardt, T. A., Lippolis, J. D., Sacco, R. E., Nonnecke, B. J. (2012). Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements. Nutrients, 4(3), 181-196, https://doi.org/10.3390/nu4030181
-
Nelson, C. D., Merriman, K. E. (2014). Vitamin D metabolism in dairy cattle and implications for dietary requirements. In 25th Annual Florida Ruminant Nutrient Symposium, 78-90.
-
Nelson, C. D., Powell, J. L., Price, D. M., Hersom, M. J., Yelich, J. V., Drewnoski, M. E., Bridges, G. A. (2016a). Assessment of serum 25-hydroxyvitamin D concentrations of beef cows and calves across seasons and geographical locations. Journal of Animal Science, 94(9), 3958-3965, https://doi.org/10.2527/jas.2016-0611
-
Nelson, C. D., Lippolis, J. D., Reinhardt, T. A., Sacco, R. E., Powell, J. L., Drewnoski, M. E., Weiss, W. P. (2016b). Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of dairy science, 99(12), 10150-10160, https://doi.org/10.3168/jds.2016-11727
-
Öngen, B., Kabaroğlu, C., Parıldar, Z. (2008). D vitamininin biyokimyasal ve laboratuvar değerlendirmesi. Türk Klinik Biyokimya Dergisi, 6, 23-31.
-
Paffoni, A., Ferrari, S., Viganò, P., Pagliardini, L., Papaleo, E., Candiani, M., Somigliana, E. (2014). Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. The Journal of Clinical Endocrinology & Metabolism, 99(11), E2372-E2376, https://doi.org/10.1210/jc.2014-1802
-
Pontes, G. C. D. S., Monteiro Jr, P. L. J., Prata, A. B., Guardieiro, M. M., Pinto, D. A. M., Fernandes, G. O., Sartori, R. (2015). Effect of injectable vitamin E on incidence of retained fetal membranes and reproductive performance of dairy cows. Journal of dairy science, 98(4), 2437-2449, https://doi.org/10.3168/jds.2014-8886
-
Pu, Y., Wang, Z., Bian, Y., Zhang, F., Yang, P., Li, Y., Zhang, X. (2014). All‐trans retinoic acid improves goat oocyte nuclear maturation and reduces apoptotic cumulus cells during in vitro maturation. Animal Science Journal, 85(9), 833-839, https://doi.org/10.1111/asj.12216
-
Qureshi, Z. I, Siddiq, M., Lodhi, L. A., Muhammad, G., Jamil, H. (2009). Effect of vitamin E-selenium administration during late gestation on productive and reproductive performance in dairy buffaloes and on growth performance of their calves. Pakistan Veterinary Journal, 30(2), 83-86.
-
Radostits, O. M., Gay, C. C., Hinchcliff, K. W., Constable, P. D. (2007). A textbook of the diseases of cattle, horses, sheep, pigs and goats. Vet. Med, 10, 2045-2050.
-
Ribeiro, E. S., Gomes, G., Greco, L. F., Cerri, R. L. A., Vieira-Neto, A., Monteiro Jr, P. L. J., Santos, J. E. P. (2016). Carryover effect of postpartum inflammatory diseases on developmental biology and fertility in lactating dairy cows. Journal of dairy science, 99(3), 2201-2220, https://doi.org/10.3168/jds.2015-10337
-
Roche, J. R., Burke, C. R., Crookenden, M. A., Heiser, A., Loor, J. L., Meier, S., Turner, S. A. (2018). Fertility and the transition dairy cow. Reproduction, Fertility and Development, 30(1), 85-100, https://doi.org/10.1071/RD17412
-
Rode, L. M., Coulter, G. H., Kastelic, J. P., Bailey, D. R. C. (1995). Seminal quality and sperm production in beef bulls with chronic dietary vitamin A deficiency and subsequent re-alimentation. Theriogenology, 43(7), 1269-1277, https://doi.org/10.1016/0093-691X(95)00098-S
-
Shastak, Y., Obermueller-Jevic, U., Pelletier, W. (2023). A century of vitamin E: Early milestones and future directions in animal nutrition. Agriculture, 13(8), 1526, https://doi.org/10.3390/agriculture13081526
-
Sönmez, M., Bozkurt, T., Türk, G., Gür, S., Kızıl, M., Yüce, A. (2009). The effect of vitamin E treatment during preovulatory period on reproductive performance of goats following estrous synchronization using intravaginal sponges. Animal Reproduction Science, 114(1-3), 183-192, https://doi.org/10.1016/j.anireprosci.2008.09.007
-
Starič, J. (2010). Dynamics of biochemical markers of bone metabolism in dairy cows treated with high dose of vitamin D3 as prevention against periparturient hypocalcaemia. (PhD thesis). University of Ljubljana, Veterinary Faculty, Slovenia.
-
Şahin, N. (2008). Vitaminler. Hayvan Besleme ve Beslenme Hastalıkları. 85-112, Medipres, Malatya.
Trojačanec, S., Boboš, S., Pajić, M. (2012). Influence of β-carotene and vitamin A supplementation on the ovarian activity of dairy cows with chronic fertility impairment. Veterinarski Arhiv, 82(6), 567-575.
-
Tuncer, Ş. D. (2008). Hayvan Besleme ve Beslenme Hastalıkları. Ergün, A., Tuncer, Ş. D., Çolpan, İ,, Yalçın, S., Yıldız, G., Küçükersan, M. K., Küçükersan, S., Şehu, A. (Ed). Süt Sığırlarının Beslenmesi. 253-299, Ankara.
-
Turan, Ö. D. (2018). Vitamin D Level and Infertility. Meandros Med Dental J, 19(2), 106-110, https://doi.org/10.4274/meandros.2399
-
Turner, R. J., Finch, J. M. (1991). Selenium and the immune response. Proceedings of the Nutrition Society, 50(2), 275-285, https://doi.org/10.1079/PNS19910037
-
Valastyan, S., Thakur, V., Johnson, A., Kumar, K., Manor, D. (2008). Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis. Biochemistry, 47(2), 744-752, https://doi.org/10.1021/bi701432q
-
Verstuyf, A., Carmeliet, G., Bouillon, R., Mathieu, C. (2010). Vitamin D: a pleiotropic hormone. Kidney international, 78(2), 140-145, https://doi.org/10.1038/ki.2010.17
-
Xiao, J., Khan, M. Z., Ma, Y., Alugongo, G. M., Ma, J., Chen, T., Cao, Z. (2021). The antioxidant properties of selenium and vitamin E; their role in periparturient dairy cattle health regulation. Antioxidants, 10(10), 1555, https://doi.org/10.3390/antiox10101555
-
Xu, J., Lawson, M. S., Xu, F., Du, Y., Tkachenko, O. Y., Bishop, C. V., Hennebold, J. D. (2018). Vitamin D3 regulates follicular development and intrafollicular vitamin D biosynthesis and signaling in the primate ovary. Frontiers in physiology, 9, 1600, https://doi.org/10.3389/fphys.2018.01600
-
Yao, X., Wang, Z., El-Samahy, M. A., Ren, C., Liu, Z., Wang, F., You, P. (2020). Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat. Reproduction, Fertility and Development, 32(3), 335-348, https://doi.org/10.1071/RD18442
-
Yazıcıoğlu, Ö. (1994). Sığırlarda hipovitaminosis-A. Etlik Veteriner Mikrobiyoloji Dergisi, 7(5), 183-194.
Yeşil, M., Sarıözkan, S. (2017). Dişi üreme sistemi açısından önemli bazı vitamin ve mineraller. Erciyes Üniv Vet Fak Derg, 14(3), 201-208.
-
Yılmaz, N., Seven, B. (2021) Üreme Sağlığı ve D Vitamini. Turkish Journal of Reproductive Medicine and Surgery, 5(1), 36-42, https: doi.org//10.24074/tjrms.2020-80791
-
Zafalon, R. V. A., Ruberti, B., Rentas, M. F., Amaral, A. R., Vendramini, T. H. A., Chacar, F. C., Brunetto, M. A. (2020). The role of vitamin D in small animal bone metabolism. Metabolites, 10(12), 496, https://doi.org/10.3390/metabo10120496
-
Zingg, J. M. (2007). Vitamin E: an overview of major research directions. Molecular aspects of medicine, 28(5-6), 400-422, https://doi.org/10.1016/j.mam.2007.05.004