Effect of Fox Pathway on Cancer

Year 2024, , 698 - 706, 07.12.2024

Funda Kosova , Nurcan Umur

https://doi.org/10.58605/bingolsaglik.1491979

Abstract

Cancer; It is a disease caused by changes in critical genes that control cell proliferation, differentiation and survival. Continuous and uncontrolled proliferation of cells is the fundamental change that causes cancer to develop. Cells freed from the control of various control mechanisms continue to proliferate, causing the formation of an abnormal cell mass that grows unusually. Under normal circumstances, if new cells are not needed, some mechanism within each cell tells the cell to stop dividing. However, cancer cells continue to grow and divide and spread to other parts of the body. Cancer cells accumulate and form tumors (masses). Tumors can compress, infiltrate or destroy normal tissues. Scientific studies continue on many molecules in order to use them in the diagnosis of diseases. The ability to use even one of these molecules for diagnostic purposes is very important for clinicians in diagnosing the disease. When we look at the literature, we see that biomarkers are used in research in many areas. Ang-2 is a protein that plays a role in the growth and stabilization of blood vessels. Some studies on Ang-2 have shown that Ang-2 levels may be associated with the prognosis of cancer. It is thought that Foxa2 may also play a role in the pathogenesis of cancer. Some studies have suggested that Foxa2 expression may be associated with the prognosis of cancer. However, the use of these biomarkers has not yet been approved for the diagnosis or treatment of cancer. Therefore, further research is needed on the effects of these biomarkers on cancer. In this review, we aimed to investigate the relationships between cancer and the Foxa2 pathway and present it to the reader from a broad perspective.

Keywords

Cancer, Ang-2, Foxa2

Fox Pathway’inin Kanser Üzerine Etkisi

Abstract

Kanser; hücrenin çoğalmasını, farklılaşmasını ve sağ kalımını denetleyen kritik genlerde meydana gelen değişikliklerden kaynaklanan bir hastalıktır. Hücrelerin sürekli ve kontrolsüz çoğalması kanserin gelişmesine neden olan temel değişikliktir. Çeşitli kontrol mekanizmalarının denetiminden kurtulan hücreler çoğalmalarına devam ederek sıra dışı büyüyen anormal hücre kitlesinin oluşmasına neden olmaktadırlar. Normal şartlar altında, eğer yeni hücreler gerekmiyorsa her hücrenin içinde bulunan bazı mekanizmalar hücreye bölünmesini durdurmasını söyler. Buna karşın kanser hücreleri, büyümeye ve bölünmeye devam ederler ve vücudun diğer bölgelerine yayılırlar. Kanser hücreleri birikerek tümörleri (kitleleri) oluştururlar, tümörler normal dokuları sıkıştırabilirler, içine sızabilirler ya da tahrip edebilirler. Hastalıkların tanısında kullanabilmek amacıyla birçok molekül üzerinde bilimsel çalışmalar devam etmektedir. Bu moleküllerden bir tanesinin bile tanı amacıyla kullanılabilmesi, klinisyenler açısından hastalığın tanısının konmasında oldukça önemlidir. Literatüre baktığımızda biyobelirteçlerin birçok alanda araştırmalarda kullanıldığı görülmektedir. Ang-2 protein olup, kan damarlarının büyümesi ve stabilizasyonunda rol oynar. Ang-2 ile ilgili yapılan birtakım araştırmalarda, Ang-2 seviyelerinin kanserin prognozu ile ilişkili olabileceğini göstermiştir. Foxa2 de kanserin patogenezinde rol oynayabileceği düşünülmektedir. Bazı çalışmalar, Foxa2 ekspresyonunun kanserin prognozu ile ilişkili olabileceğini öne sürmüştür. Ancak, bu biyobelirteçlerin kullanımı kanserin tanısı veya tedavisi için henüz onaylanmamıştır. Bu nedenle, bu biyobelirteçlerin kanser üzerindeki etkileri hakkında daha fazla araştırma yapılması gerekmektedir. Biz bu derlemede, kanser ile Foxa2 patway arasındaki ilişkileri araştırmayı ve geniş bir perspektifle okuyucuya sunmayı hedefledik.

Keywords

Kanser, Ang-2, Foxa2

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