Three-dimensional reconstruction and morphometry of the mandible in New Zealand rabbits

Abstract

This study was conducted to create three-dimensional (3D) models of the lower jaw using computed tomography (CT) images of New Zealand rabbits and to reveal whether there are differences between genders. 12 New Zealand rabbits (6 female, 6 male) were used in the study. Computed tomography (CT) images of the animals were taken, and a three-dimensional model of the mandible was obtained from the two-dimensional images using the MIMICS 20.1 program. Length measurements were performed on the resulting 3D model. When the values measured in male and female rabbits were compared, it was determined that the length between the molars (B) was longer in females, and the corona length of the lower jaw teeth (I) was longer in males and was statistically significant (p <0.05). It is thought that the 3D mandible model and measurements obtained in this study would be a resource for researchers working on experimental mandibular surgery in rabbits, would guide researchers as reference data in creating a rabbit model, would assist the physician in the clinic, and would help learn the anatomy of this region.

Keywords

• Computer tomography
• mandible
• rabbit
• 3D reconstruction

References

1. Akbulut Y, Demiraslan Y, Gürbüz İ, Aslan K (2014) Yeni Zelanda tavşanı (Oryctolaguscuniculus L.)’ında cinsiyet faktörünün mandibula morfometrisine etkisi. Fırat Üniv Sağl Bil Vet Derg 28(1):15-18.
2. Baskin JZ, White BM, Vasanji A, Love TE, Eppell SJ (2021) Mandible biomechanics and continuously erupting teeth: a new defect model for studying load-bearing biomaterials. Biomedicines 9(7):730. doi:10.3390/biomedicines9070730
3. Borie E, Calzzani R, Dias FJ, Fuentes R, Salamanca C (2017) Morphometry of rabbit anatomical regions used as experimental models in implantology and oral surgery. Biomed Res J 28(12):5486-5472.
4. Campillo VE, Langonnet S, Pierrefeu A, Chaux-Bodard AG (2014) Anatomic and histological study of the rabbit mandible as an experimental model for wound healing and surgical therapies. Lab anim 48(4):273-277. doi:10.1177/0023677214540635
5. Dayan MO, Beşoluk K, Eken E, Aydoğdu S, Turgut N (2019) Three-dimensional modelling of the femur and humerus in adult male guinea pigs (guinea pig) with computed tomography and some biometric measurement values. Folia Morphol 78(3):588-594. doi:10.5603/FM.a2019.0002
6. El-Bialy T, El-Shamy I, Graber TM (2003) Growth modification of the rabbit mandible using therapeutic ultrasound: is it possible to enhance functional appliance results?. Angle Orthod 73(6):631-639. doi:10.1043/0003-3219(2003)073<0631:GMOTRM>2.0.CO;2
7. Haleem A, Javaid M (2019) 3D scanning applications in medical field: a literature-based review. CEGH 7(2):199-210. doi:10.1016/j.cegh.2018.05.006
8. Kim MK, Ham MJ, Kim WR, Kim HG, Kwon KJ, Kim SG, Park YW (2023) Investigating the accuracy of mandibulectomy and reconstructive surgery using 3D customized implants and surgical guides in a rabbit model. Maxillofac Plast Reconstr Surg 45(8):1-17. doi:10.1186/s40902-023-00375-9

9. Li Y, Chen SK, Li L, Qin, L, Wang XL, Lai YX (2015) Bone defect animal models for testing efficacy of bone substitute biomaterials. J Orthop Translat 3(3):95-104. doi:10.1016/j.jot.2015.05.002
10. Monfared AL (2013). Applied anatomy of the rabbit’s skull and its clinical application during regional anesthesia. Glob Vet 10(6):653-7. doi:10.5829/idosi.gv.2013.10.6.72111
11. Nomina Anatomica Veterinaria (2017) International committee on veterinary gross anatomical nomenclature (6th ed. (Revised version)). Published by the Editorial Committee Hannover (Germany), Columbia, MO (USA), Ghent (Belgium), Sapporo (Japan).
12. Remzi OA, Caner B, Okan E, Ufuk K, Nuriye ÖK (2019) Accuracy and reliability of measurements obtained from 3-dimensional rabbit mandible model: a micro-computed tomography study. Acta Vet 69(2):192-200. doi:10.2478/acve-2019-0015
13. Salih QM (2016) Morphological and morph metric study of the mandible in the local Rabbits (Oryctolagus Cunicuius). Iraqi J Vet Med 40(1):25-29.
14. Selcuk ML (2023) Computed tomography reconstruction and morphometric analysis of the humerus and femur in New Zealand rabbits. Eurasian J Vet Sci 39(4):164-170. doi:10.15312/EurasianJVetSci.2023.413
15. Selçuk ML, Tıpırdamaz S (2020) A morphological and stereological study on brain, cerebral hemispheres and cerebellum of New Zealand rabbits. Anat, histol, embryol 49(1):90-96. doi:10.1111/ahe.12489
16. Schlund M, Depeyre A, Ranganath SK, Marchandise P, Ferri J, Chai F (2022) Rabbit calvarial and mandibular critical-sized bone defects as an experimental model for the evaluation of craniofacial bone tissue regeneration. J Stomatol Oral Maxillofac Surg 123(6):601-609. doi:10.1016/j.jormas.2021.12.001
17. Turgut N, Bahar S, Kılınçer A (2023) CT and cross‐sectional anatomy of the paranasal sinuses in the Holstein cow. Vet Radiol Ultrasound 64(2):211-223. doi:10.1111/vru.13166
18. Wang Y, Zhang X, Mei S, Li Y, Khan AA, Guan S, Li X (2023) Determination of critical-sized defect of mandible in a rabbit model: Micro-computed tomography, and histological evaluation. Heliyon 9(7):e18047. doi:10.1016/j.heliyon.2023.e18047