Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats

Year 2023, Volume: 1 Issue: 1, 16 - 22, 30.05.2023

Elif Atabay , Yusuf Kalender

Abstract

Bisphenol A (BPA) is an endocrine disruptor chemical that is frequently used in industry. Taurine is a low molecular weight organic compound in living organisms. Curcumin is a yellow colored bioactive compound of turmeric with antioxidant properties. In this study, the protective effects of taurine and curcumin on the histopathological changes, antioxidant enzyme activities [superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx)] and malondialdehyde (MDA) levels that BPA may cause in the lung tissue of rats were investigated. Rats were divided into 7 groups. 1st group: control group, 2nd group: oil group, 3rd group: taurine (100 mg/kg day) treated group, 4th group: curcumin (100 mg/kg day) treated group, 5th group: BPA (130 mg/kg day) treated group group, 6th group: BPA plus taurine treated group, 7th group: BPA plus curcumin treated group. After the application by gavage for 4 weeks, a statistically significant increase was observed in the MDA levels in the lung tissues of the rats when the BPA treated group was compared with the control group, while a statistically significant decrease was observed in the antioxidant enzyme activities (SOD, CAT, GST, GPx). When the groups treated with BPA plus taurine, BPA plus curcumin were compared with the group treated with BPA, a decrease was observed in the MDA levels in the lung tissues of the rats, while a statistically significant increase was observed in SOD, CAT, GST and GPx enzyme activities. In histopathological examinations, it was determined that while BPA caused cell infiltration, hemorrhage, atrophy and emphysema in the lung tissue of rats, taurine and curcumin reduced these pathological changes.

Keywords

Lung, antioxidants, bisphenol A, histopathology, oxidative stress

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