The Importance of Serum Total and Lipid-Bound Sialic Acid as Markers in Patients With Small Cell and Non-Small Cell Lung Carcinoma

Abstract

Objectives: Serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were investigated in patients with small and non-small cell lung carcinoma and their role in discriminating small from non-small cell lung carcinoma and lung carcinoma from healthy individuals was evaluated. Patients and Methods: The study included 159 male patients with non-small cell lung carcinoma (n=102) and small cell lung carcinoma (n=57) who never received chemotherapy and/or radiotherapy and 35 healthy volunteers as controls. Serum TSA and LSA levels were determined by the methods of Warren and Katopodis, respectively. Results: Serum TSA and LSA levels in both patient groups were significantly elevated when compared with controls (p<0.001), but the patient groups did not differ significantly in this respect. Receiver operating characteristic (ROC) analysis showed that TSA was more specific and LSA was more sensitive in distinguishing patients with non-small cell carcinoma from healthy individuals. On the other hand, LSA was found to be more sensitive in distinguishing patients with small cell carcinoma from healthy controls. Conclusion: Serum total and lipid-bound sialic acid may play an important role as biochemical markers in distinguishing patients with small and non-small cell lung carcinoma from healthy subjects. Turkish Başlık: Küçük Hücreli ve Küçük Hücreli Dışı Akciğer Kanserli Hastalarda Serum Total ve Lipide Bağlı Siyalik Asidin Marker Olarak Önemi Anahtar Kelimeler: Küçük hücreli akciğer kanseri; küçük hücreli dışı akciğer kanseri; total siyalik asit; lipide bağlı siyalik asit; marker Amaç: Küçük hücreli ve küçük hücreli dışı akciğer kanserli hastalarda serum total siyalik asit (TSA) ve lipide bağlı siyalik asit (LSA) düzeyleri incelendi ve hastaları sağlıklı bireylerden ve birbirinden ayırmada bu parametrelerin marker olarak rolü irdelendi. Hastalar ve Yöntemler: Çalışmaya henüz hiç kemoterapi ve/veya radyoterapi almamış 102 küçük hücreli dışı ve 57 küçük hücreli akciğer kanserli toplam 159 erkek hasta ve 35 sağlıklı erkek gönüllü dahil edildi. Serum TSA analizinde Warren yöntemi, LSA analizinde Katopodis yöntemi kullanıldı. Bulgular: Küçük hücreli ve küçük hücreli dışı akciğer kanserli hastaların serum TSA ve LSA düzeyleri sağlıklılara göre anlamlı olarak yüksekti (p<0.001), ancak bu iki hasta grubu arasında bu açıdan anlamlı farklılık bulunmadı. ROC (Receiver operating characteristic) analizinde, küçük hücreli dışı akciğer kanserli hastaları sağlıklılardan ayırmada TSA'nın özgüllüğünün, LSA'nın ise duyarlılığının daha iyi olduğu görüldü. Öte yandan, küçük hücreli akciğer kanserli hastaları sağlıklılardan ayırmada LSA'nın daha duyarlı olduğu saptandı. Sonuç:Serum total ve lipide bağlı siyalik asit, küçük hücreli ve küçük hücreli dışı akciğer kanserli hastaları sağlıklılardan ayırmada biyokimyasal marker olarak önemli rol oynayabilir.

Keywords

• Small cell lung cancer; non small cell lung cancer; total sialic acid; lipid-bound sialic acid; marker

Küçük Hücreli ve Küçük Hücreli Dışı Akciğer Kanserli Hastalarda Serum Total ve Lipide Bağlı Siyalik Asidin Marker Olarak Önemi

Öz

Küçük hücreli akciğer kanseri; küçük hücreli dışı akciğer kanseri; total siyalik asit; lipide bağlı siyalik asit; marker Amaç: Küçük hücreli ve küçük hücreli dışı akciğer kanserli hastalarda serum total siyalik asit (TSA) ve lipide bağlı siyalik asit (LSA) düzeyleri incelendi ve hastaları sağlıklı bireylerden ve birbirinden ayırmada bu parametrelerin marker olarak rolü irdelendi. Hastalar ve Yöntemler: Çalışmaya henüz hiç kemoterapi ve/veya radyoterapi almamış 102 küçük hücreli dışı ve 57 küçük hücreli akciğer kanserli toplam 159 erkek hasta ve 35 sağlıklı erkek gönüllü dahil edildi. Serum TSA analizinde Warren yöntemi, LSA analizinde Katopodis yöntemi kullanıldı. Bulgular: Küçük hücreli ve küçük hücreli dışı akciğer kanserli hastaların serum TSA ve LSA düzeyleri sağlıklılara göre anlamlı olarak yüksekti (p < 0.001), ancak bu iki hasta grubu arasında bu açıdan anlamlı farklılık bulunmadı. ROC (Receiver operating characteristic) analizinde, küçük hücreli dışı akciğer kanserli hastaları sağlıklılardan ayırmada TSA'nın özgüllüğünün, LSA'nın ise duyarlılığının daha iyi olduğu görüldü. Öte yandan, küçük hücreli akciğer kanserli hastaları sağlıklılardan ayırmada LSA'nın daha duyarlı olduğu saptandı. Sonuç:Serum total ve lipide bağlı siyalik asit, küçük hücreli ve küçük hücreli dışı akciğer kanserli hastaları sağlıklılardan ayırmada biyokimyasal marker olarak önemli rol oynayabilir.

Anahtar Kelimeler

• Küçük hücreli akciğer kanseri, küçük hücreli dışı akciğer kanseri, total siyalik asit, lipide bağlı siyalik asit, marker

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