Efficacy and Tolerability of Sertaconazole Nitrate in Mycotic Vaginitis

Abstract

Objectives: In this research, single-dose of 300 mg sertaconazole nitrate ovule in mycotic vaginitis has been evaluated in terms of clinical and microbiological efficacy and safety. Patients and Methods: The study included 177 patients (mean age 31.8±7.8 years; range 15 to 53 years) who applied to our polyclinics with vaginitis complaints. Patients having cottage cheese-like discharge, vaginal pH<4.5, Whiff test (-) were accepted as mycotic vaginitis. To determine mycotic agents in vaginal discharge, samples were cultured in Sabouraud glucose agar. As a treatment, patients were administered a single-dose of 300 mg sertaconazole nitrate ovule. Its clinical and microbiological aspects have been evaluated in the first visit, a week after and finally one month after the first visit. Symptoms related to vaginitis, clinical and microbiological recovery rates and adverse effects have been noted. Results: All symptom scores were significantly lower in the second visit, and all except dysuria complaint in the third visit. Clinical recovery rates in the second and third visit were in 76.0% and 79.5%. According to mycotic culture test results, the microbiologic recovery rates were 88.8% in the second and 91.4% in the third visits. Conclusion: Single-dose sertaconazole nitrate ovule was evaluated as a convenient, symptom-relieving and safe treatment for mycotic vaginitis. Turkish Başlık: Mikotik Vajinitlerde Sertakonazol Nitratın Etkinliği ve Tolerabilitesi Anahtar Kelimeler: Mikotik vajinit; sertakonazol nitrat; etkinlik ve tolerabilite. Amaç: Bu çalışmada tek doz 300 mg sertakonazol nitrat ovul'un mikotik vajinitlerde klinik ve mikrobiyolojik etkinliği, uygunluğu ve güvenilirliliği değerlendirildi. Hastalar ve Yöntemler: Polikliniğimize vajinit yakınması ile başvuran 117 olgu (ort. yaş 31.8±7.8; dağılım 15-53) incelemeye alındı. Çökelek tarzı akıntısı olan, vajinal pH<4.5, Whiff testi (-) saptanan olgular mikotik vajinit olarak kabul edildi. Bu olgulardaki mikotik ajanları tespit etmek amacıyla akıntı örnekleri Sabouraud glukoz agar besi yerine ekim yapıldı. Tedavi olarak olguların tek doz 300 mg sertakonazol nitrat ovul kullanmaları istendi. Klinik ve mikrobiyolojik olarak tüm olgular ilk vizitte, bir hafta sonra ve son olarak bir ay sonra tekrar değerlendirildi. Vajinit ile ilgili semptom skorları, klinik ve mikrobiyolojik iyileşme oranları ve yan etkileri kaydedildi. Bulgular: Olguların semptom skorları incelendiğinde ikinci vizitte tüm semptomlarda üçüncü vizitte ise dizüri şikayetleri dışındaki semptomlarda anlamlı ölçüde azalma saptandı. Klinik iyileşme oranları ikinci ve üçüncü vizitte %76.0 ve %79.5 olarak saptandı. İkinci ve üçüncü vizitteki mikrobiyolojik iyileşme oranları ise %88.8 ve %91.4 olarak belirlendi. Sonuç: Tek doz sertakonazol nitrat ovul vajinal mikoz tedavisinde kolay uygulanabilir, etkili ve güvenilir olarak değerlendirildi.: Tek doz sertakonazol nitrat ovul vajinal mikoz tedavisinde kolay uygulanabilir, etkili ve güvenilir olarak değerlendirildi.

Keywords

• Mycotic vaginitis; sertaconazole; efficacy and tolerability.

Mikotik Vajinitlerde Sertakonazol Nitratın Etkinliği ve Tolerabilitesi

Öz

Amaç: Bu çalışmada tek doz 300 mg sertakonazol nitrat ovul’un mikotik vajinitlerde klinik ve mikrobiyolojik etkinliği, uygunluğu ve güvenilirliliği değerlendirildi. Hastalar ve Yöntemler: Polikliniğimize vajinit yakınması ile başvuran 117 olgu (ort. yaş 31.8±7.8; dağılım 15-53) incelemeye alındı. Çökelek tarzı akıntısı olan, vajinal pH

Anahtar Kelimeler

• Mikotik vajinit, sertakonazol nitrat, etkinlik ve tolerabilite

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