Comparision of the Side Effects Due To Interferon Alpha 2A Plus Ribavirin and Pegylated Interferon Alpha 2A Plus Ribavirin Combinations For Chronic Hepatitis C Infection

Abstract

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Keywords

• Pegylated interferon alpha 2a + ribavirin; interferon alpha 2a + ribavirin; side effects

Kronik Hepatit C İnfeksiyonda Pegileinterferon Alfa 2A ve Ribavirin Kombinasyonu ile İnterferon Alfa 2A ve Ribavirin Kombinasyonunun Yan Etkilerinin Karşılaştırılması

Öz

Amaç: Kronik hepatit C infeksiyonunda interferon alfa 2a ve ribavirin, pegile interferon alfa 2a ve ribavirin kombinasyonuna bağlı oluşan yan etkiler karşılaştırıldı.Hastalar ve Yöntemler: Bu çalışmada, haftada üç kez 3 milyon U subkutan interferon alfa 2a ve 1000-1200 mg/gün oral ribavirin alan 36 hasta ile haftada bir subkutan 180 µgr pegile interferon alfa 2a ve 1000-1200 mg/gün oral ribavirin alan 49 hasta ile ilişkili yan etkiler karşılaştırıldı.Bulgular: Pegile interferon alfa grubunda en sık görülen yan etkiler iştahsızlık, baş ağrısı, ve yorgunluktur. Bu fark gruplar arasında istatistiksel olarak anlamlıdır (p < 0.05). Sonuç: Çalışmamızda interferon ve ribavirin alan 2 hastada (bir hastada anemi, diğer hastada anemi ve trombositopeni) pegile interferon ve ribavirin alan üç hastada (bir hastada anemi, bir hastada anemi ve trombositopeni, diğerinde psikiyatrik problemler) tedavi kesildi.

Anahtar Kelimeler

• Pegile interferon alfa 2a + ribavirin, interferon alfa 2a + ribavirin, yan etki.

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