The Evaluation of Protein C Activity and Some Infl ammatory Markers in Synovia of Patients Undergoing Total Knee Arthroplasty
Abstract
Objective: Total knee arthroplasty (TKA) is a major risk factor for thrombosis in patients over 40 years of age and this risk persists for several weeks after the surgery. Since inflammatory mechanisms affect coagulation and the natural anticoagulant system, we aimed to investigate protein C activities and inflammatory markers in patients undergoing TKA surgery. Material and Methods: We included 20 osteoarthritis patients and 20 healthy controls. Protein C activity and tumor necrosis factor-α (TNF-α) levels in plasma and synovia were evaluated by ELISA technique. Results: In the patient group, protein C activities decreased and TNF-α levels increased significantly both in synovia and plasma when compared with the controls. Erythrocyte sedimentation rate of the patient group was found to be significantly elevated in comparison to the controls. On the other hand, serum C reactive protein values increased insignificantly when compared to controls. Conclusion: The decreased activity of protein C and increased levels of inflammatory markers in preoperative plasma and synovia of the patient group may enhance the risk for developing thrombosis.
Keywords
References
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- Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue infl ammation in early and late osteoarthritis. Ann Rheum Dis 2005;64:1263-7.
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- Weinberg JB, Pippen AM, Greenberg SC. Extravascular Ş brin formation and dissolution in synovial tissue of patients with os- teoarthritis and rheumatoid arthritis. Arthritis and Rheumatism 1991;34:996-1005.
- Fisher CR, Yan SB. Protein C levels as a prognostic indica- tor of outcome in sepsis and related disease. Crit Care Med 2000;28:S49-56.
- Cicala C, Cirino G. Linkage between infl ammation and coagula- tion: an update on the molecular basis of the crosstalk. Life Sci- ence 1998;62:1817-24.
- Van de Loo FA, Joosten LAB, van Lent P, Arntz OJ, van den Berg WB. Role of interleukin -1 tumor necrosis factor alfa and inter- leukin-6 in cartilage proteoglycan metabolism and destruction: effect of in situ blocking in murine antigen and zymosan induced arthritis. Arthritis Rheum 1995;38:164-72.
- Cermak J, Key NS, Bech R, Balla J, Cacob HS, Vercellotti GM. C reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood 1993;82:513-20.
- Cheras PA, Whitaker AN, Blackwell EA, Sinton TJ, Chapman MD, Peacock KA. Hypercoagulability and hypoŞ brinolysis in primary osteoarthritis. Clin Orthop 1997;334:57-67.
- So AK, Varisco PA, Kemkes-Matthes B, Kerkenne-Morad C, Chobaz-Peclat V. Arthritis is linked to local and systemic activa- tion of coagulation and Ş brinolysis pathways. J Thromb Haemost 2003;1:2510-5.
- Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classiŞ cation and reporting of 171 2011; 28: 169-72 Alturfan et al.
- Total Knee Arthroplasty and Infl ammatory Markers
The Evaluation of Protein C Activity and Some Infl ammatory Markers in Synovia of Patients Undergoing Total Knee Arthroplasty
Abstract
References
- Haris ED, Budd RC, Firestein GS, Genovese MC, Sergent JS, Ruddy S. et al. Pathogenesis of osteoarthritis. In: Cesare PE, Abramson SB, editors. Kelley’s Textbook of Rheumatology, 7th ed. Philadelphia: Elsevier; 2005;1493-8.
- Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue infl ammation in early and late osteoarthritis. Ann Rheum Dis 2005;64:1263-7.
- Craven S, Dewar L, Yang X, Ginsberg J, Ofosu F. Altered regulation of in-vivo coagulation in orthopedic patients prior to knee or hip replacement surgery. Blood Coagul Fibrinolysis 2007;18:219-25.
- Weinberg JB, Pippen AM, Greenberg SC. Extravascular Ş brin formation and dissolution in synovial tissue of patients with os- teoarthritis and rheumatoid arthritis. Arthritis and Rheumatism 1991;34:996-1005.
- Fisher CR, Yan SB. Protein C levels as a prognostic indica- tor of outcome in sepsis and related disease. Crit Care Med 2000;28:S49-56.
- Cicala C, Cirino G. Linkage between infl ammation and coagula- tion: an update on the molecular basis of the crosstalk. Life Sci- ence 1998;62:1817-24.
- Van de Loo FA, Joosten LAB, van Lent P, Arntz OJ, van den Berg WB. Role of interleukin -1 tumor necrosis factor alfa and inter- leukin-6 in cartilage proteoglycan metabolism and destruction: effect of in situ blocking in murine antigen and zymosan induced arthritis. Arthritis Rheum 1995;38:164-72.
- Cermak J, Key NS, Bech R, Balla J, Cacob HS, Vercellotti GM. C reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood 1993;82:513-20.
- Cheras PA, Whitaker AN, Blackwell EA, Sinton TJ, Chapman MD, Peacock KA. Hypercoagulability and hypoŞ brinolysis in primary osteoarthritis. Clin Orthop 1997;334:57-67.
- So AK, Varisco PA, Kemkes-Matthes B, Kerkenne-Morad C, Chobaz-Peclat V. Arthritis is linked to local and systemic activa- tion of coagulation and Ş brinolysis pathways. J Thromb Haemost 2003;1:2510-5.
- Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classiŞ cation and reporting of 171 2011; 28: 169-72 Alturfan et al.
- Total Knee Arthroplasty and Infl ammatory Markers
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | February 1, 2011 |
| Published in Issue | Year 2011 |