Pediatric Parapharyngeal Castleman’s Disease: a Case Report

Abstract

Castleman’s disease is a rare lymphoproliferative disorder of unknown aetiology. It has two clinical expressions. The localized form, which usually presents as a slow growing mass and the multicentric form, where tumoural involvement is multilocated. Mediastinal involvement is the most common location of presentation. Parapharyngeal involvement is very rare and, to our knowledge, five pediatric parapharyngeal Castleman’s disease have been reported. We describe the case of a 14-year-old female child who was diagnosed as having parapharyngeal Castleman’s disease.

Keywords

• Castleman’s disease,parapharyngeal,childhood

Parafarengeal Yerleşimli Pediatrik Castleman Hastalığı: Olgu Sunumu

Öz

Castleman hastalığı, nedeni ve etyolojisi belli olmayan nadir bir lenfoproliferatif hastalıktır. İki klinik formu vardır. Lokalize form; genellikle yavaş büyüyen kitle şeklinde kendini gösterir. Multisentrik form ise, birden fazla anatomik bölgeyi tutar. Hastalık en sık mediastinal bölgede yerleşir. Parafarengeal yerleşim ise çok nadir olup, literatüre bakıldığında bizim ulaşabildiğimiz kadarıyla çocukluk çağında toplam beş parafarengeal yerleşimli Castleman hastalığı vakası bildirilmiştir. Bu yazıda, parafarengeal yerleşimli Castleman hastalığı tanısı alan, 14 yaşında bir kız hasta sunulmuştur.

Anahtar Kelimeler

• Castleman hastalığı, parafarengeal, çocukluk çağı

References

1. Parez N, Bader-Meunier B, Roy CC, Dommergues JP. Pediatric Castleman Disease: report of seven cases and review of the lit- erature. Eur J Pediatr 1999;158:631-7. [CrossRef]
2. Frizzera G, Peterson BA, Bayrd ED, Goldman A. A systemic lym- phoproliferative disorder with morphologic features of Castle- man’s disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol 1985;3:1202-16.
3. Fisher ER, Sieracki JC, Goldenberg DM. Identity and nature of isolated lymphoid tumors (so-called nodal hyperplasia, hamar- toma, and angiomatous hamartoma) as revealed by histologic, electron microscopic, and heterotransplantation studies. Cancer 1970;25:1286-300. [CrossRef]
4. Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plas- ma-cell types of giant lymph node hyperplasia of the mediasti- num and other locations. Cancer 1972;29:670-83. [CrossRef]
5. Frizzera G, Banks P, Massarelli G, Rosai J. A systemic lypmho- proliferative disorder with morphologic features of Castleman’s disease. Am J Surg Pathol 1983;7:211-31. [CrossRef]
6. Frizzera G. Castleman’s disease and related disorders. Semin Di- agn Pathol 1988;5:346-64.
7. Salisbury JR. Castleman’s disease in childhood and adoles- cence: report of a case and review of literature. Pediatr Pathol 1990;10:609-15. [CrossRef]
8. Castleman B, Towne VW. Case records of the Massachusetts Gen- eral Hospital: case no. 40231. N Eng J Med 1954;250:1001-5.

9. Topal Ö, Alataş N, Erbek S, Erbek SS, Tosun E. Castleman’s dis- ease in a patient with recurrent reactive lymphadenopathy. Kulak Burun Bogaz Ihtis Derg 2008;18:377-80. 327
10. ; 28: 325-7 Erbey ve ark.
11. Parafarengeal Castleman Hastalığı
12. Ide C, De Coene B, Lawson G, Betsch C, Trigaux JP. Castleman’s dis- ease in the neck: MRI. Neuroradiology 1997;39:520-2. [CrossRef]
13. Dangoor E, Elidan J, Gomori JM, Dano I. Castleman’s disease of the retropharynx: a benign tumor in a 12-year-old girl. Am J Otolaryngol 1998;19:194-7. [CrossRef]
14. Ottaviani F, Galli J, Di Girolamo S, Almadori G. Castleman’s disease restricted to the parapharyngeal space. J Otolaryngol 1999;28:95-8.
15. Freeman SJ, Irvine GH, Glew D. Case report: cervical Castleman’s disease shown by CT and MRI. Clin Radiol 1994;49:721-3. [CrossRef]
16. Schrock A, Gutgemann I, Keiner S. Castleman’s disease in ear, nose, and throat practice. HNO 2007;55:E29-32. [CrossRef]
17. Hsu SM, Waldron JW, Xie SS, Barlogie B. Expression of interleukine-6 in Castleman’s disease. Hum Pathol 1993;24:833-9. [CrossRef]
18. Bowne WB, Lewis JJ, Flippa DA, Niesvizky R, Brooks AD, Burt ME, et al. The management of unicentric and multicentric Castle- man’s disease: a report of 16 cases and a review of the literature. Cancer 1999;85:706-17. [CrossRef]
19. Sherman JA, Birtwhistle CJ, Davies HT. A rapidly expanding le- sion in the neck: unusual presentation of Castleman’s disease. Int J Oral Maxillofac Surg 2001;30:458-60. [CrossRef]
20. Weisenburger DD, Nathwani BN, Winberg CD, Rappaport H. Mul- ticentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol 1985;16:162-72. [CrossRef]