Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

Sercan Göde; Göksel Turhal; Ceyda Tarhan; Banu Yaman; Gülşen Kandiloğlu; Kerem Öztürk; İsa Kaya; Raşit Midilli; Bülent Karcı

Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

Öz

Background: Mucosal melanoma is a rare malignancy arising from melanocytes of the mucosal surfaces. The pattern and frequency of oncogenic mutations and histopathological biomarkers have a role on distinct tumour behaviour and survival. Aims: To assess the rate of C-KIT positivity and its effect on survival of surgically treated sinonasal malignant melanoma patients with other histopathological biomarkers and clinical features. Study Design: Retrospective cross-sectional study. Methods: Seventeen sinonasal malignant melanoma patients with a mean age of 65.41 (39-86) years were included. Overall survival and disease-specific survival rates were calculated. The impact of age, gender, stage and extent of the disease, type of surgery, and adjuvant therapies were also taken into consideration. The effect of mitotic index, pigmentation, S100, HMB-45, Melan-A and C-KIT on survival were evaluated. Results: Median tumour size was 20 mm (interquartile range=27.5 mm). Pigmentation was present in 7 (41.2%) cases. Median number of mitoses per millimetre squared was 11 (interquartile range=13). Melan A was positive in 7 (41.2%) patients, ulceration was present in 6 cases (35.3%), and necrosis was present in (47.1%) 8 cases. Six patients (35.3%) were positive for S100, 14 (82.4%) specimens stained positive for HMB-45 and C-KIT (CD117) was positive in 9 cases (52.9%). Three patients (16.7%) developed distant metastasis. Five year overall and disease free survival rates were 61.4% and 43.8%, respectively. Conclusion: Although C-KIT positive sinonasal malignant melanoma patients (52.9%) can be candidates for targeted tumour therapies, the studied clinical or histopathological features along with C-KIT seem to have no significant effect on survival in a small group of patients with sinonasal malignant melanoma.

Anahtar Kelimeler

Malignant melanoma, nasal cavity, paranasal sinuses, C-KIT, sinonasal malignancy, mucosal melanoma

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Sercan Göde This is me

Göksel Turhal This is me

Ceyda Tarhan This is me

Banu Yaman This is me

Gülşen Kandiloğlu This is me

Kerem Öztürk This is me

İsa Kaya This is me

Raşit Midilli This is me

Bülent Karcı This is me

Publication Date

May 1, 2017

Submission Date

May 1, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 34 Number: 3

IZ

https://izlik.org/JA93TR28BM

Cite

RIS / Bibtex

APA

Göde, S., Turhal, G., Tarhan, C., Yaman, B., Kandiloğlu, G., Öztürk, K., Kaya, İ., Midilli, R., & Karcı, B. (2017). Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal, 34(3), 255-262. https://izlik.org/JA93TR28BM

AMA

1.Göde S, Turhal G, Tarhan C, et al. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. 2017;34(3):255-262. https://izlik.org/JA93TR28BM

Chicago

Göde, Sercan, Göksel Turhal, Ceyda Tarhan, et al. 2017. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal 34 (3): 255-62. https://izlik.org/JA93TR28BM.

EndNote

Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B (May 1, 2017) Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal 34 3 255–262.

IEEE

[1]S. Göde et al., “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”, Balkan Medical Journal, vol. 34, no. 3, pp. 255–262, May 2017, [Online]. Available: https://izlik.org/JA93TR28BM

ISNAD

Göde, Sercan - Turhal, Göksel - Tarhan, Ceyda - Yaman, Banu - Kandiloğlu, Gülşen - Öztürk, Kerem - Kaya, İsa - Midilli, Raşit - Karcı, Bülent. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal 34/3 (May 1, 2017): 255-262. https://izlik.org/JA93TR28BM.

JAMA

1.Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. 2017;34:255–262.

MLA

Göde, Sercan, et al. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal, vol. 34, no. 3, May 2017, pp. 255-62, https://izlik.org/JA93TR28BM.

Vancouver

1.Sercan Göde, Göksel Turhal, Ceyda Tarhan, Banu Yaman, Gülşen Kandiloğlu, Kerem Öztürk, İsa Kaya, Raşit Midilli, Bülent Karcı. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal [Internet]. 2017 May 1;34(3):255-62. Available from: https://izlik.org/JA93TR28BM