Lipid Peroxidation and Transforming Growth Factor-β1 Levels in Gastric Cancer at Pathologic Stages

Abstract

Objective: High levels of TGF-β1 and enhanced TGF-β1 receptor signaling are related to the pathology of gastric cancer. This effect is caused by oxidative stress and lipid peroxidation products. The aim of this study was to investigate the levels of TGF-β1 and lipid peroxidation products in gastric cancer patients and their correlation with pathologic stage. Material and Methods: Lipid peroxidation products and TGF-β1 levels were studied in the serum samples of 50 gastric cancer patients and 18 control subjects. Results: HNE-protein adducts and TGF-β1 levels were significantly higher in T2, T3 and T4 gastric cancers than in either the T1 stage or controls (p<0.001). Pathologic stage was correlated with TGF-β1 levels (r=0.702, p<0.05). Conclusion: These markers production may contribute to tumor angiogenesis and aid in the prognosis of the gastric cancer. Turkish Anahtar Kelimeler: Mide kanseri, lipid peroksidasyon, TGF-β1 Amaç: Yüksek TGF-β1 seviyeleri ve gelişmiş TGF-β1 reseptör sinyalizasyonu mide kanseri patolojisi ile ilişkilidir. Bu etki oksidatif stres ve lipid peroksidasyon ürünleri tarafından oluşmaktadır. Bu çalışmada amaç, mide kanserli hastalarda TGF-β1 ve lipit peroksidasyon ürün düzeylerini ve bu ürünlerin patolojik evre ile korelasyonunu araştırmaktı. Materyal ve Metod: Mide kanserli 50 hasta ve sağlıklı 18 kişinin serumunda lipid peroksidasyon ürün ve TGF-β1 seviyelerine bakıldı. Sonuçlar: T2, T3 ve T4 tümörlü hastaların HNE ve TGF-β1 seviyeleri hem T1 hem de sağlıklı kişilere göre anlamlı derecede yüksek bulundu (p<0.001). TGF-β1 seviyeleri patolojik evre ile korele idi (r=0.702, p<0.05). Sonuç: Bu markırların üretimi, tümör anjiyogenezisine katkıda bulunabilir ve mide kanseri prognozunun belirlenmesinde yardımcı olabilir.

Keywords

• Gastric cancer, lipid peroxidation, TGF-β1

Lipid Peroxidation and Transforming Growth Factor-β1 Levels in Gastric Cancer at Pathologic Stages

Öz

References

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19. TGF- β1 Levels in Gastric Cancer