Cervical Adenoid Basal Carcinoma: A Case Report

Abstract

Adenoid basal carcinoma (ABC) is a rare epithelial tumor of the cervix. It makes up approximately 1% of all cervical adenocarcinomas. Rare cases have been associated with common cervical epithelial tumors. We present a case of ABC associated with typical squamous cell carcinoma. A 54-year-old postmenopausal woman underwent D&C for vaginal bleeding. Histologically, the tumor was characterized by small cells with a narrow cytoplasm, making up islands and cords. Peripheral palissading in the cells surrounding the cystic areas that contained central cellular debris and keratin was noted. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy and omentectomy. Large cell keratinized type squamous cell carcinoma areas in the cervix were noted besides the limited ABC areas. After surgery, the patient was treated with radiation therapy. A retroperitoneal metastasis was found on the first year and chemotherapy was administered. The patient has no evidence of disease 27 months after the first diagnosis. ABC makes up quite a rare group of cervical cancers and should be kept in mind during the evaluation so that a differentiation can be made with tumors with similar morphology as it can show various histological patterns, and can be seen together with more aggressive cancers.

Keywords

• Adenoid basal carcinoma, HPV, cervix, squamous cell carcinoma

Cervical Adenoid Basal Carcinoma: A Case Report

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References

1. 1. Baggish MS, Woodruff JD. Adenoid-basal carcinoma of the cervix. Obstet Gynecol 1966;2:213-8.
2. 2. Baggish MS, Woodruff JD. Adenoid basal lesions of the cervix. Obstet Gynecol 1971;6:807-19.
3. 3. DePond WD, Flauta VS, Lingamfelter DC, Schnee DM, Menendez KP. Adenoid basal carcinoma of the cervix in a 20-year-old female: a case report. Diagn Pathol 2006;1:20. [CrossRef]
4. 4. Ferry JA, Scully RE. “Adenoid cystic” carcinoma and adenoid basal carcinoma of the uterine cervix. A study of 28 cases. Am J Surg Pathol 1988;2:134-44. [CrossRef]
5. 5. Cviko A, Briem B, Granter SR, Pinto AP, Wang TY, Yang YC, et al. Adenoid basal carcinomas of the cervix: a unique morphological evolution with cell cycle correlates. Hum Pathol 2000;6:740-4. [CrossRef]
6. 6. Mills, Stacey E. Sternberg’s Diagnostic surgical pathology. Philadelphia: Lippincott Williams & Wilkins, 2010 (Nucci R.M, Crum C.P,ed. The Cervix)
7. 7. Grayson W, Taylor LF, Cooper K. Carcinosarcoma of the uterine cervix: a report of eight cases with immunohistochemical analysis and evaluation of human papillomavirus status. Am J Surg Pathol 2001;3:338-47. [CrossRef]
8. 8. Parwani AV, Smith Sehdev AE, Kurman RJ, Ronnett BM. Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and P16 expression. Hum Pathol 2005;1:82-90. [CrossRef]

9. 9. Russell MJ, Fadare O. Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts. Diagn Pathol 2006;1:18. [CrossRef]
10. 10. Kurman RJ, Ellenson LH, Ronnett BM. Blaunstein’s Pathology of the Female Genital Tract. New York: Springer 2011(Kurman RJ, ed. Adenoid basal carcinoma)
11. 11. Zámecník M, Skrivánek A. Adenoid basal epithelioma of the uterin cervix in 21-year-old patient. Report of a case with histologic and immunohistochemical study. Cesk Patol 2005;4: 157-62.
12. 12. Senzaki H, Osaki T, Uemura Y, Kiyozuka Y, Ogura E, Okamura A, et al. Adenoid basal carcinoma of the uterine cervix: Immunohistochemical study and literature review. Jpn J Clin Oncol 1997;6:437-441. [CrossRef]
13. 13. Hiroi M, Fukunaga T, Miyazaki E, Hayashi Y, Kuroda N, Toi M, et al. Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings. Med Electron Microsc 2000;33: 241-5. [CrossRef]
14. 14. Jones MW, Kounelis S, Papadaki H, Bakker A, Swalsky PA, Finkelstein SD. The origin and molecular characterization of adenoid basal carcinoma of the uterine cervix. Int J Gynecol Pathol 1997;4:301-6. [CrossRef]
15. 15. Takeshima Y, Amatya VJ, Nakayori F, Nakano T, Iwaoki Y, Daitoku K, et al. Co-existent carcinosarcoma and adenoid basal carcinoma of the uterine cervix and correlation with human papillomavirus infection. Int J Gynecol Pathol 2002;2: 186-90. [CrossRef]