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The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease

Year 2002, Volume: 2002 Issue: 1, - , 01.01.2002

Abstract

Objectives: This study was designed to compare serum total and lipid-bound sialic acid levels obtained from patients with and without coronary obstruction. Patients and Methods: Serum total and lipid-bound sialic acid levels were determined in 42 patients (29 men, 13 women; mean age 58 years; range 32 to 75 years) with angiographically documented coronary obstruction and in 35 patients (22 men, 13 women; mean age 54 years; range 39 to 75 years) with no obstruction. Serum total and lipid-bound sialic acid levels were determined by the methods of Warren and Katopodis, respectively. The results were compared with the use of one-way ANOVA test. Results: Serum total and lipid-bound sialic acid levels were significantly higher in patients with coronary obstruction (81.01±10.10 mg/dl and 33.59±7.00 mg/dl, respectively) when compared with those of patients with no obstruction (65.18±10.23 mg/dl and 25.28±7.40 mg/dl, respectively) (p<0.001). Conclusion: The measurement of serum total and lipid-bound sialic acid levels may be useful in distinguishing between patients with and without coronary obstruction. Turkish Başlık: Koroner Kalp Hastalarında Damar Tıkanıklığı ile Serum Total ve Lipide Bağlı Sialik Asit Düzeyleri Arasındaki İlişki Anahtar Kelimeler: Akut faz proteinleri; anjina pektoris/kan; biyolojik belirteçler; serebrovasküler hastalıklar/kan; goğüs ağrısı/kan; koroner anjiyografi; koroner arterioskleroz; koroner hastalık/kan; lipid/kan; lipoprotein, HDL kolesterol; miyokard infarktüsü/ kan; risk faktörleri; sialik asit/kan Amaç: Damar tıkanıklığı olan koroner kalp hastaları ve damar tıkanıklığı olmayan hastalar serum total ve lipide bağlı sialik asit düzeyleri yönünden karşılaştırıldı. Hastalar ve Yöntemler: Anjiyografi ile damar tıkanıklığı saptanmış 42 koroner kalp hastasında (29 erkek, 13 kadın; ort. yaş 58; dağılım 32-75) ve damar tıkanıklığı saptanmamış 35 hastada (22 erkek, 13 kadın; ort. yaş 54; dağılım 39-75) serum total sialik asit ve lipide bağlı sialik asit düzeyleri ölçüldü. Total sialik asit düzeyleri Warren yöntemi ile, lipide bağlı sialik asit düzeyleri Katopodis yöntemi ile belirlendi. Gruplar tek yönlü ANOVA testi ile karşılaştırıldı. Bulgular: Damar tıkanıklığı olan koroner kalp hastaları nda serum total sialik asit (81.01±10.10 mg/dl) ve lipide bağlı sialik asit (33.59±7.00 mg/dl) düzeyleri, damar tıkanıklığı saptanmamış hastalara (sırasıyla 65.18±10.23 mg/dl ve 25.28±7.40 mg/dl) göre anlamlı derecede daha yüksek bulundu (p<0.001). Sonuç: Serum total ve lipide bağlı sialik asit düzeylerinin ölçülmesi, damar tıkanıklığı olan koroner kalp hastalarını damar tıkanıklığı olmayan hastalardan ayırmada yardımcı olabilir.

The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease

Year 2002, Volume: 2002 Issue: 1, - , 01.01.2002

Abstract

Objectives: This study was designed to compare serum total and lipid-bound sialic acid levels obtained from patients with and without coronary obstruction. Patients and Methods: Serum total and lipid-bound sialic acid levels were determined in 42 patients (29 men, 13 women; mean age 58 years; range 32 to 75 years) with angiographically documented coronary obstruction and in 35 patients (22 men, 13 women; mean age 54 years; range 39 to 75 years) with no obstruction. Serum total and lipid-bound sialic acid levels were determined by the methods of Warren and Katopodis, respectively. The results were compared with the use of one-way ANOVA test. Results: Serum total and lipid-bound sialic acid levels were significantly higher in patients with coronary obstruction (81.01±10.10 mg/dl and 33.59±7.00 mg/dl, respectively) when compared with those of patients with no obstruction (65.18±10.23 mg/dl and 25.28±7.40 mg/dl, respectively) (p<0.001). Conclusion: The measurement of serum total and lipid-bound sialic acid levels may be useful in distinguishing between patients with and without coronary obstruction. Turkish Başlık: Koroner Kalp Hastalarında Damar Tıkanıklığı ile Serum Total ve Lipide Bağlı Sialik Asit Düzeyleri Arasındaki İlişki Anahtar Kelimeler: Akut faz proteinleri; anjina pektoris/kan; biyolojik belirteçler; serebrovasküler hastalıklar/kan; goğüs ağrısı/kan; koroner anjiyografi; koroner arterioskleroz; koroner hastalık/kan; lipid/kan; lipoprotein, HDL kolesterol; miyokard infarktüsü/ kan; risk faktörleri; sialik asit/kan Amaç: Damar tıkanıklığı olan koroner kalp hastaları ve damar tıkanıklığı olmayan hastalar serum total ve lipide bağlı sialik asit düzeyleri yönünden karşılaştırıldı. Hastalar ve Yöntemler: Anjiyografi ile damar tıkanıklığı saptanmış 42 koroner kalp hastasında (29 erkek, 13 kadın; ort. yaş 58; dağılım 32-75) ve damar tıkanıklığı saptanmamış 35 hastada (22 erkek, 13 kadın; ort. yaş 54; dağılım 39-75) serum total sialik asit ve lipide bağlı sialik asit düzeyleri ölçüldü. Total sialik asit düzeyleri Warren yöntemi ile, lipide bağlı sialik asit düzeyleri Katopodis yöntemi ile belirlendi. Gruplar tek yönlü ANOVA testi ile karşılaştırıldı. Bulgular: Damar tıkanıklığı olan koroner kalp hastaları nda serum total sialik asit (81.01±10.10 mg/dl) ve lipide bağlı sialik asit (33.59±7.00 mg/dl) düzeyleri, damar tıkanıklığı saptanmamış hastalara (sırasıyla 65.18±10.23 mg/dl ve 25.28±7.40 mg/dl) göre anlamlı derecede daha yüksek bulundu (p<0.001). Sonuç: Serum total ve lipide bağlı sialik asit düzeylerinin ölçülmesi, damar tıkanıklığı olan koroner kalp hastalarını damar tıkanıklığı olmayan hastalardan ayırmada yardımcı olabilir.

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Details

Primary Language Turkish
Journal Section Articles
Authors

Selma Süer Gökmen This is me

Gülseven Kılıçlı This is me

Fatih Özçelik This is me

Atilla Birsin This is me

Şendoğan Gülen This is me

Publication Date January 1, 2002
Published in Issue Year 2002 Volume: 2002 Issue: 1

Cite

APA Gökmen, S. S., Kılıçlı, G., Özçelik, F., Birsin, A., et al. (2002). The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease. Balkan Medical Journal, 2002(1).
AMA Gökmen SS, Kılıçlı G, Özçelik F, Birsin A, Gülen Ş. The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease. Balkan Medical Journal. January 2002;2002(1).
Chicago Gökmen, Selma Süer, Gülseven Kılıçlı, Fatih Özçelik, Atilla Birsin, and Şendoğan Gülen. “The Relationship Between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients With Coronary Heart Disease”. Balkan Medical Journal 2002, no. 1 (January 2002).
EndNote Gökmen SS, Kılıçlı G, Özçelik F, Birsin A, Gülen Ş (January 1, 2002) The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease. Balkan Medical Journal 2002 1
IEEE S. S. Gökmen, G. Kılıçlı, F. Özçelik, A. Birsin, and Ş. Gülen, “The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease”, Balkan Medical Journal, vol. 2002, no. 1, 2002.
ISNAD Gökmen, Selma Süer et al. “The Relationship Between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients With Coronary Heart Disease”. Balkan Medical Journal 2002/1 (January 2002).
JAMA Gökmen SS, Kılıçlı G, Özçelik F, Birsin A, Gülen Ş. The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease. Balkan Medical Journal. 2002;2002.
MLA Gökmen, Selma Süer et al. “The Relationship Between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients With Coronary Heart Disease”. Balkan Medical Journal, vol. 2002, no. 1, 2002.
Vancouver Gökmen SS, Kılıçlı G, Özçelik F, Birsin A, Gülen Ş. The Relationship between Vessel Obstruction and Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Coronary Heart Disease. Balkan Medical Journal. 2002;2002(1).