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Multimodal Imaging with PET-CT in Oncology

Year 2006, Volume: 2006 Issue: 2, 55 - 64, 01.02.2006

Hans Jürgen Bıersack Mahmut Yüksel Holger Palmedo Roland Rödel Micheal Reınhardt Ursula Jaeger

Abstract

The combination of PET (positron emission tomography) with CT (computed tomography) has considerably enhanced the clinical application of PET. PET-CT combines the high resolution of CT with the high sensitivity of PET. As PET and CT results are obtained with one machine during one investigation, an optimal fusion of both procedures is possible. The accuracy of PET can be increased by about 15% by PET-CT, compared to conventional fusion of PET and CT images. The potential of PET-CT can only be fully used if contrast agents -either orally or intravenously- are applied. The Xrays of CT may also be used for attenuation correction. This article focuses mainly on PET-CT in lung cancer, malignant melanoma, head and neck tumors, thyroid tumors, and colorectal cancer, with illustrations of some cases documenting the potentials of PET-CT. Turkish Başlık: Onkolojide PET-BT ile Multimodal Görüntüleme Anahtar Kelimeler: Fluorodeoksiglukoz F18/tanısal kullanım; görüntü artırma; görüntü işleme, bilgisayar destekli/yöntem; tümör metastazı; pozitron-emisyon tomografi/yöntem; bilgisayarlı tomografi/yöntem Pozitron-emisyon tomografi (PET) ile bilgisayarlı tomografinin (BT) birlikte kullanımı (PET-BT) PET'in klinik kullanımını önemli ölçüde artırmıştır. PET-BT, BT'nin yüksek çüzünürlüğünü PET'in yüksek duyarlığıyla birleştirmektedir. PET ve BT sonuçlarının tek incelemede ve aynı cihazla elde edilmesi nedeniyle her iki prosedürün en uygun birleşimi mümkündür. PET ve BT görüntülerinin klasik birleştirilmesine oranla, PET-BT ile PET'in doğruluğu yaklaşık %15 oranında artırılabilir. PET-BT'nin gücünden tam olarak yararlanmak sadece oral veya intravenöz kontrast ajanların kullanılmasıyla mümkündür. BT'nin X- ışını aynı zamanda atenüasyon düzeltmesi için kullanılır. Bu makalede ağırlıklı olarak akciğer kanseri, malign melanom, baş-boyun tümörleri, tiroid tümörleri ve kolorektal kanserler üzerinde durulmuş ve PET-BT'nin görsel gücü olgulara ait görüntüler aracılığıyla ortaya konmuştur.

Keywords

Fluorodeoxyglucose F18/diagnostic use; image enhancement; image processing computer-assisted/methods; neoplasm metastasis; positron-emission tomography/methods; tomography X-ray computed/methods

References

  • Kinahan PE, Hasegawa BH, Beyer T. X-ray-based attenuation correction for positron emission tomog- raphy/computed tomography scanners. Semin Nucl Med 2003;33:166-79.
  • Beyer T. Design, construction and validation of a combined PET/CT tomograph for clinical oncology. [Doctoral thesis] University of Surrey, UK: 1999.
  • Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41: 1369-79.
  • Pfluger T, la Fougere C, Stauss J, Santos R, Vollmar C, Hahn K. Combined scanners (PET/CT, SPECT/CT) versus multimodality imaging with separated systems. [Article in German] Radiologe 2004;44:1105-12.
  • Bunyaviroch T, Coleman RE. PET evaluation of lung cancer. J Nucl Med 2006;47:451-69.
  • Cohade C, Osman M, Marshall LN, Wahl RN. PET- CT: accuracy of PET and CT spatial registration of lung lesions. Eur J Nucl Med Mol Imaging 2003; 30:721-6.
  • Goerres GW, Kamel E, Seifert B, Burger C, Buck A, Hany TF, et al. Accuracy of image coregistration of pulmonary lesions in patients with non-small cell lung cancer using an integrated PET/CT system. J Nucl Med 2002;43:1469-75.
  • Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small-cell lung can- cer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003; 348:2500-7.
  • Reinhardt MJ, Wiethoelter N, Matthies A, Joe AY, Strunk H, Jaeger U, et al. PET recognition of pul- monary metastases on PET/CT imaging: impact of attenuation-corrected and non-attenuation-correct- ed PET images. Eur J Nucl Med Mol Imaging 2006; 33:134-9.
  • Reinhardt MJ, Joe AY, Jaeger U, Huber A, Matthies A, Bucerius J, et al. Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experi- ence with 250 consecutive patients. J Clin Oncol 2006;24:1178-87.
  • Rodel R, Straehler-Pohl HJ, Palmedo H, Reichmann K, Jaeger U, Reinhardt MJ, et al. PET/CT imaging in head and neck tumors. [Article in German] Radiologe 2004;44:1055-9.
  • Palmedo H, Bucerius J, Joe A, Strunk H, Hortling N, Meyka S, et al. Integrated PET/CT in differentiated thyroid cancer: Diagnostic accuracy and impact on patient management. J Nucl Med 2006;47:616-24.
  • Strunk H, Bucerius J, Jaeger U, Joe A, Flacke S, Reinhardt M, et al. Combined FDG PET/CT imag- ing for restaging of colorectal cancer patients: impact of image fusion on staging accuracy. [Article in German] Rofo 2005; 177:1235-41.
  • Schoder H, Larson SM, Yeung HW. PET/CT in oncology: integration into clinical management of lymphoma, melanoma, and gastrointestinal malig- nancies. J Nucl Med 2004;45 Suppl 1:72S-81S.
  • Cohade C, Osman M, Leal J, Wahl RL. Direct com- parison of (18)F-FDG PET and PET/CT in patients with colorectal carcinoma. J Nucl Med 2003;44:1797- 803.
  • Reinhardt MJ, Strunk H, Gerhardt T, Roedel R, Jaeger U, Bucerius J, et al. Detection of Klatskin’s tumor in extrahepatic bile duct strictures using delayed 18F-FDG PET/CT: preliminary results for 22 patient studies. J Nucl Med 2005;46:1158-63.

Onkolojide PET-BT ile Multimodal Görüntüleme

Year 2006, Volume: 2006 Issue: 2, 55 - 64, 01.02.2006

Hans Jürgen Bıersack Mahmut Yüksel Holger Palmedo Roland Rödel Micheal Reınhardt Ursula Jaeger

Abstract

Pozitron-emisyon tomografi (PET) ile bilgisayarlı tomografinin (BT) birlikte kullanımı (PET-BT) PET'in klinik kullanımını önemli ölçüde artırmıştır. PET-BT, BT'nin yüksek çüzünürlüğünü PET'in yüksek duyarlığıyla birleştirmektedir. PET ve BT sonuçlarının tek incelemede ve aynı cihazla elde edilmesi nedeniyle her iki prosedürün en uygun birleşimi mümkündür. PET ve BT görüntülerinin klasik birleştirilmesine oranla, PET-BT ile PET'in doğruluğu yaklaşık %15 oranında artırılabilir. PET-BT'nin gücünden tam olarak yararlanmak sadece oral veya intravenöz kontrast ajanların kullanılmasıyla mümkündür. BT'nin X- ışını aynı zamanda atenüasyon düzeltmesi için kullanılır. Bu makalede ağırlıklı olarak akciğer kanseri, malign melanom, baş-boyun tümörleri, tiroid tümörleri ve kolorektal kanserler üzerinde durulmuş ve PET-BT'nin görsel gücü olgulara ait görüntüler aracılığıyla ortaya konmuştur.

Keywords

Fluorodeoksiglukoz F18/tanısal kullanım görüntü artırma görüntü işleme bilgisayar destekli/yöntem tümör metastazı pozitron-emisyon tomografi/yöntem bilgisayarlı tomografi/yöntem

References

  • Kinahan PE, Hasegawa BH, Beyer T. X-ray-based attenuation correction for positron emission tomog- raphy/computed tomography scanners. Semin Nucl Med 2003;33:166-79.
  • Beyer T. Design, construction and validation of a combined PET/CT tomograph for clinical oncology. [Doctoral thesis] University of Surrey, UK: 1999.
  • Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41: 1369-79.
  • Pfluger T, la Fougere C, Stauss J, Santos R, Vollmar C, Hahn K. Combined scanners (PET/CT, SPECT/CT) versus multimodality imaging with separated systems. [Article in German] Radiologe 2004;44:1105-12.
  • Bunyaviroch T, Coleman RE. PET evaluation of lung cancer. J Nucl Med 2006;47:451-69.
  • Cohade C, Osman M, Marshall LN, Wahl RN. PET- CT: accuracy of PET and CT spatial registration of lung lesions. Eur J Nucl Med Mol Imaging 2003; 30:721-6.
  • Goerres GW, Kamel E, Seifert B, Burger C, Buck A, Hany TF, et al. Accuracy of image coregistration of pulmonary lesions in patients with non-small cell lung cancer using an integrated PET/CT system. J Nucl Med 2002;43:1469-75.
  • Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small-cell lung can- cer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003; 348:2500-7.
  • Reinhardt MJ, Wiethoelter N, Matthies A, Joe AY, Strunk H, Jaeger U, et al. PET recognition of pul- monary metastases on PET/CT imaging: impact of attenuation-corrected and non-attenuation-correct- ed PET images. Eur J Nucl Med Mol Imaging 2006; 33:134-9.
  • Reinhardt MJ, Joe AY, Jaeger U, Huber A, Matthies A, Bucerius J, et al. Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experi- ence with 250 consecutive patients. J Clin Oncol 2006;24:1178-87.
  • Rodel R, Straehler-Pohl HJ, Palmedo H, Reichmann K, Jaeger U, Reinhardt MJ, et al. PET/CT imaging in head and neck tumors. [Article in German] Radiologe 2004;44:1055-9.
  • Palmedo H, Bucerius J, Joe A, Strunk H, Hortling N, Meyka S, et al. Integrated PET/CT in differentiated thyroid cancer: Diagnostic accuracy and impact on patient management. J Nucl Med 2006;47:616-24.
  • Strunk H, Bucerius J, Jaeger U, Joe A, Flacke S, Reinhardt M, et al. Combined FDG PET/CT imag- ing for restaging of colorectal cancer patients: impact of image fusion on staging accuracy. [Article in German] Rofo 2005; 177:1235-41.
  • Schoder H, Larson SM, Yeung HW. PET/CT in oncology: integration into clinical management of lymphoma, melanoma, and gastrointestinal malig- nancies. J Nucl Med 2004;45 Suppl 1:72S-81S.
  • Cohade C, Osman M, Leal J, Wahl RL. Direct com- parison of (18)F-FDG PET and PET/CT in patients with colorectal carcinoma. J Nucl Med 2003;44:1797- 803.
  • Reinhardt MJ, Strunk H, Gerhardt T, Roedel R, Jaeger U, Bucerius J, et al. Detection of Klatskin’s tumor in extrahepatic bile duct strictures using delayed 18F-FDG PET/CT: preliminary results for 22 patient studies. J Nucl Med 2005;46:1158-63.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Hans Jürgen Bıersack This is me

Mahmut Yüksel This is me

Holger Palmedo This is me

Roland Rödel This is me

Micheal Reınhardt This is me

Ursula Jaeger This is me

Publication Date February 1, 2006
Published in Issue Year 2006 Volume: 2006 Issue: 2

Cite

APA Bıersack, H. J., Yüksel, M., Palmedo, H., Rödel, R., et al. (2006). Onkolojide PET-BT ile Multimodal Görüntüleme. Balkan Medical Journal, 2006(2), 55-64.
AMA Bıersack HJ, Yüksel M, Palmedo H, Rödel R, Reınhardt M, Jaeger U. Onkolojide PET-BT ile Multimodal Görüntüleme. Balkan Medical Journal. February 2006;2006(2):55-64.
Chicago Bıersack, Hans Jürgen, Mahmut Yüksel, Holger Palmedo, Roland Rödel, Micheal Reınhardt, and Ursula Jaeger. “Onkolojide PET-BT Ile Multimodal Görüntüleme”. Balkan Medical Journal 2006, no. 2 (February 2006): 55-64.
EndNote Bıersack HJ, Yüksel M, Palmedo H, Rödel R, Reınhardt M, Jaeger U (February 1, 2006) Onkolojide PET-BT ile Multimodal Görüntüleme. Balkan Medical Journal 2006 2 55–64.
IEEE H. J. Bıersack, M. Yüksel, H. Palmedo, R. Rödel, M. Reınhardt, and U. Jaeger, “Onkolojide PET-BT ile Multimodal Görüntüleme”, Balkan Medical Journal, vol. 2006, no. 2, pp. 55–64, 2006.
ISNAD Bıersack, Hans Jürgen et al. “Onkolojide PET-BT Ile Multimodal Görüntüleme”. Balkan Medical Journal 2006/2 (February 2006), 55-64.
JAMA Bıersack HJ, Yüksel M, Palmedo H, Rödel R, Reınhardt M, Jaeger U. Onkolojide PET-BT ile Multimodal Görüntüleme. Balkan Medical Journal. 2006;2006:55–64.
MLA Bıersack, Hans Jürgen et al. “Onkolojide PET-BT Ile Multimodal Görüntüleme”. Balkan Medical Journal, vol. 2006, no. 2, 2006, pp. 55-64.
Vancouver Bıersack HJ, Yüksel M, Palmedo H, Rödel R, Reınhardt M, Jaeger U. Onkolojide PET-BT ile Multimodal Görüntüleme. Balkan Medical Journal. 2006;2006(2):55-64.