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Subacute Thyroiditis Following Treatment for Cushing Syndrome

Year 2007, Volume: 2007 Issue: 3, 235 - 239, 01.03.2007

Abstract

Thyroid diseases frequently accompany Cushing syndrome (CS). Nodular or diffuse goitre and autoimmune thyroid diseases may be evident during or after treatment of CS. A 29-year-old female presented with weight gain, hypertension and hirsutismus. Examinations revealed hypercortisolemia. Computed tomography revealed a solid mass 2.5-3 cm in size in the left surrenal gland and adrenalectomy was done. The diagnosis was adrenal cortical adenoma. A few days later she complained of pain in the left ear, neck, and head, which was diagnosed as subacute thyroiditis. To our knowledge, subacute thyroiditis accompanying CS is not reported in the literature before. Turkish Başlık: Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu Anahtar Kelimeler: Adrenalektomi; Cushing sendromu; subakut tiroidit Tiroid hastalıkları sıklıkla Cushing sendromuna (CS) eşlik ederler. Nodüler veya diffüz guatr ile otoimmün tiroid hastalıkları, CS'nin seyrinde veya bu nedenle tedavi gördükten sonra ortaya çıkabilir. Yirmi dokuz yaşında kadın hasta kilo alımı, hipertansiyon ve hirsutismus nedeniyle başvurdu. İncelemeler sonucu hiperkortizolemi saptandı. Bilgisayarlı tomografide sol sürrenal glandda 2.5-3 cm çapında kitle görüldü ve adrenalektomi yapıldı, adrenal kortikal adenoma tanısına varıldı. Birkaç gün sonra ortaya çıkan sol boyun, kulak ve baş ağrısının değerlendirilmesi sonucu subakut tiroidit tanısı konuldu. Literatürde daha önce bildirilmiş CS'ye eşlik eden subakut tiroidit olgusuna rastlanmamıştır.

References

  • Invitti C, Manfrini R, Romanini BM, Cavagnini F. High prevalence of nodular thyroid disease in patients with Cushing’s disease. Clin Endocrinol (Oxf) 1995;43:359-63.
  • Yakushiji F, Kita M, Hiroi N, Ueshiba H, Monma I, Miyachi Y. Exacerbation of rheumatoid arthritis after removal of adrenal adenoma in Cushing’s syndrome. Endocr J 1995;42:219-23.
  • Muzulu SI, Howlett TA. Polymyalgia rheumatica presenting after successful treatment of Cushing's disease. Br J Rheumatol 1998;37:804-5.
  • Noguchi Y, Tamai H, Fujisawa K, Nagano J, Mukuta T, Komaki G, et al. Systemic lupus erythematosus after pituitary adenomectomy in a patient with Cushing’s disease. Clin Endocrinol (Oxf) 1998;48:670-2.
  • Uthman I, Senecal JL. Onset of rheumatoid arthritis after surgical treatment of Cushing's disease. J Rheumatol 1995;22:1964-6.
  • Takasu N, Komiya I, Nagasawa Y, Asawa T, Yamada T. Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushing’s syndrome due to an adrenocortical adenoma. N Engl J Med 1990;322:1708-12.
  • Arikan E, Guldiken S, Altun BU, Kara M, Tugrul A. Exacerbations of Graves’ disease after unilateral adrenalectomy for Cushing’s syndrome. J Endocrinol Invest 2004;27:574-6.
  • Brabant A, Brabant G, Schuermeyer T, Ranft U, Schmidt FW, Hesch RD, et al. The role of glucocorticoids in the regulation of thyrotropin. Acta Endocrinol (Copenh) 1989;121:95-100.
  • Brabant G, Ocran K, Ranft U, von zur Mühlen A, Hesch RD. Physiological regulation of thyrotropin. Biochimie 1989;71:293-301.
  • Wilber JF, Utiger RD. The effect of glucocorticoids on thyrotropin secretion. J Clin Invest 1969;48:2096-103.
  • Nicoloff JT, Fisher DA, Appleman MD Jr. The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest 1970;49:1922-9.
  • Otsuki M, Dakoda M, Baba S. Influence of glucocorticoids on TRF-induced TSH response in man. J Clin Endocrinol Metab 1973;36:95-102.
  • Bartalena L, Martino E, Petrini L, Velluzzi F, Loviselli A, Grasso L, et al. The nocturnal serum thyrotropin surge is abolished in patients with adrenocorticotropin (ACTH)-dependent or ACTH-independent Cushing’s syndrome. J Clin Endocrinol Metab 1991; 72:1195-9.
  • Benker G, Raida M, Olbricht T, Wagner R, Reinhardt W, Reinwein D. TSH secretion in Cushing’s syndrome: relation to glucocorticoid excess, diabetes, goitre, and the ‘sick euthyroid syndrome’. Clin Endocrinol (Oxf) 1990;33:777-86.
  • Iitaka M, Momotani N, Hisaoka T, Noh JY, Ishikawa N, Ishii J, et al. TSH receptor antibody-associated thyroid dysfunction following subacute thyroiditis. Clin Endocrinol (Oxf) 1998;48:445-53.
  • McEwen BS, Biron CA, Brunson KW, Bulloch K, Chambers WH, Dhabhar FS, et al. The role of adreno-corticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Res Rev 1997;23:79-133.
  • Wall JR, Fang SL, Ingbar SH, Braverman LE. Lymphocyte transformation in response to human thyroid extract in patients with subacute thyroiditis. J Clin Endocrinol Metab 1976;43:587-90.

Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu

Year 2007, Volume: 2007 Issue: 3, 235 - 239, 01.03.2007

Abstract

Tiroid hastalıkları sıklıkla Cushing sendromuna (CS) eşlik ederler. Nodüler veya diffüz guatr ile otoimmün tiroid hastalıkları, CS'nin seyrinde veya bu nedenle tedavi gördükten sonra ortaya çıkabilir. Yirmi dokuz yaşında kadın hasta kilo alımı, hipertansiyon ve hirsutismus nedeniyle başvurdu. İncelemeler sonucu hiperkortizolemi saptandı. Bilgisayarlı tomografide sol sürrenal glandda 2.5-3 cm çapında kitle görüldü ve adrenalektomi yapıldı, adrenal kortikal adenoma tanısına varıldı. Birkaç gün sonra ortaya çıkan sol boyun, kulak ve baş ağrısının değerlendirilmesi sonucu subakut tiroidit tanısı konuldu. Literatürde daha önce bildirilmiş CS'ye eşlik eden subakut tiroidit olgusuna rastlanmamıştır.

References

  • Invitti C, Manfrini R, Romanini BM, Cavagnini F. High prevalence of nodular thyroid disease in patients with Cushing’s disease. Clin Endocrinol (Oxf) 1995;43:359-63.
  • Yakushiji F, Kita M, Hiroi N, Ueshiba H, Monma I, Miyachi Y. Exacerbation of rheumatoid arthritis after removal of adrenal adenoma in Cushing’s syndrome. Endocr J 1995;42:219-23.
  • Muzulu SI, Howlett TA. Polymyalgia rheumatica presenting after successful treatment of Cushing's disease. Br J Rheumatol 1998;37:804-5.
  • Noguchi Y, Tamai H, Fujisawa K, Nagano J, Mukuta T, Komaki G, et al. Systemic lupus erythematosus after pituitary adenomectomy in a patient with Cushing’s disease. Clin Endocrinol (Oxf) 1998;48:670-2.
  • Uthman I, Senecal JL. Onset of rheumatoid arthritis after surgical treatment of Cushing's disease. J Rheumatol 1995;22:1964-6.
  • Takasu N, Komiya I, Nagasawa Y, Asawa T, Yamada T. Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushing’s syndrome due to an adrenocortical adenoma. N Engl J Med 1990;322:1708-12.
  • Arikan E, Guldiken S, Altun BU, Kara M, Tugrul A. Exacerbations of Graves’ disease after unilateral adrenalectomy for Cushing’s syndrome. J Endocrinol Invest 2004;27:574-6.
  • Brabant A, Brabant G, Schuermeyer T, Ranft U, Schmidt FW, Hesch RD, et al. The role of glucocorticoids in the regulation of thyrotropin. Acta Endocrinol (Copenh) 1989;121:95-100.
  • Brabant G, Ocran K, Ranft U, von zur Mühlen A, Hesch RD. Physiological regulation of thyrotropin. Biochimie 1989;71:293-301.
  • Wilber JF, Utiger RD. The effect of glucocorticoids on thyrotropin secretion. J Clin Invest 1969;48:2096-103.
  • Nicoloff JT, Fisher DA, Appleman MD Jr. The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest 1970;49:1922-9.
  • Otsuki M, Dakoda M, Baba S. Influence of glucocorticoids on TRF-induced TSH response in man. J Clin Endocrinol Metab 1973;36:95-102.
  • Bartalena L, Martino E, Petrini L, Velluzzi F, Loviselli A, Grasso L, et al. The nocturnal serum thyrotropin surge is abolished in patients with adrenocorticotropin (ACTH)-dependent or ACTH-independent Cushing’s syndrome. J Clin Endocrinol Metab 1991; 72:1195-9.
  • Benker G, Raida M, Olbricht T, Wagner R, Reinhardt W, Reinwein D. TSH secretion in Cushing’s syndrome: relation to glucocorticoid excess, diabetes, goitre, and the ‘sick euthyroid syndrome’. Clin Endocrinol (Oxf) 1990;33:777-86.
  • Iitaka M, Momotani N, Hisaoka T, Noh JY, Ishikawa N, Ishii J, et al. TSH receptor antibody-associated thyroid dysfunction following subacute thyroiditis. Clin Endocrinol (Oxf) 1998;48:445-53.
  • McEwen BS, Biron CA, Brunson KW, Bulloch K, Chambers WH, Dhabhar FS, et al. The role of adreno-corticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Res Rev 1997;23:79-133.
  • Wall JR, Fang SL, Ingbar SH, Braverman LE. Lymphocyte transformation in response to human thyroid extract in patients with subacute thyroiditis. J Clin Endocrinol Metab 1976;43:587-90.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Bengür Taşkıran This is me

Sibel Güldiken This is me

Ender Arıkan This is me

Betül Uğur Altun This is me

Armağan Tuğrul This is me

Publication Date March 1, 2007
Published in Issue Year 2007 Volume: 2007 Issue: 3

Cite

APA Taşkıran, B., Güldiken, S., Arıkan, E., Altun, B. U., et al. (2007). Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu. Balkan Medical Journal, 2007(3), 235-239.
AMA Taşkıran B, Güldiken S, Arıkan E, Altun BU, Tuğrul A. Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu. Balkan Medical Journal. March 2007;2007(3):235-239.
Chicago Taşkıran, Bengür, Sibel Güldiken, Ender Arıkan, Betül Uğur Altun, and Armağan Tuğrul. “Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu”. Balkan Medical Journal 2007, no. 3 (March 2007): 235-39.
EndNote Taşkıran B, Güldiken S, Arıkan E, Altun BU, Tuğrul A (March 1, 2007) Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu. Balkan Medical Journal 2007 3 235–239.
IEEE B. Taşkıran, S. Güldiken, E. Arıkan, B. U. Altun, and A. Tuğrul, “Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu”, Balkan Medical Journal, vol. 2007, no. 3, pp. 235–239, 2007.
ISNAD Taşkıran, Bengür et al. “Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu”. Balkan Medical Journal 2007/3 (March 2007), 235-239.
JAMA Taşkıran B, Güldiken S, Arıkan E, Altun BU, Tuğrul A. Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu. Balkan Medical Journal. 2007;2007:235–239.
MLA Taşkıran, Bengür et al. “Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu”. Balkan Medical Journal, vol. 2007, no. 3, 2007, pp. 235-9.
Vancouver Taşkıran B, Güldiken S, Arıkan E, Altun BU, Tuğrul A. Cushing Sendromu Tedavisi Sonrası Gelişen Subakut Tiroidit Olgusu. Balkan Medical Journal. 2007;2007(3):235-9.