Abstract
Objectives: Malonyldialdehid (MDA) is one of the most sensitive parameters of the lipid peroxidation. In the present study, it was aimed to investigate the value of serum MDA levels in diagnosing intracranial pathologies in minor head trauma. Patients and Methods: This prospective study was approved in Fırat University. Patients were categorized into 2 groups: those without intracranial lesions in head CTs (group 1) and those with intracranial lesions in head CTs (group 2). Serum MDA levels were determined. Results: Mean serum MDA levels in group 1 (n=50) and group 2 (n=24) were 31.186±46.9 pg/ml and 54.873±127.6 pg/ml, respectively. Statistical analysis showed no significant difference between the two groups in terms of MDA values. Conclusion: It is found that serum MDA has limited value in determining the intracranial injury detected with computed tomography in patients with minor head trauma. Turkish Başlık: Kafa İçi Yaralanmanın Tanısında Serum MDA'nın Yeri Anahtar Kelimeler: Acil servis; kafa travması; MDA; intrakraniyal hasar. Amaç: Malonildialdehid lipit peroksidasyonunun en duyarlı göstergelerinden biridir. Bu çalışmada minör kafa travmalı hastalarda serum malonildialdehid (MDA) seviyelerinin intrakraniyal hasarın tanısındaki yerinin araştırılması amaçlanmıştır. Hastalar ve Yöntemler: Çalışma Fırat Üniversitesi Tıp Fakültesi Acil Servisinde prospektif olarak yapılmıştır. Hastalar bilgisayarlı beyin tomografisinde lezyon olmayanlar (grup 1) ve olanlar (grup 2) olarak iki gruba ayrıldı. Serum MDA seviyeleri belirlendi. Bulgular: Grup 1'deki (n=50) hastaların ortalama serum MDA düzeyi 31.186±46.9 pg/ml, grup 2'deki (n=24) hastaların ise 54.873±127.6 pg/ml idi. Yapılan istatistiksel analiz sonucu bu iki grup arasında serum MDA düzeyleri açısından istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Sonuç: Minör kafa travmalı hastalarda serum MDA düzeylerinin bilgisayarlı beyin tomografisi ile saptanan intrakraniyal hasarı belirlemede etkili olmadığı tespit edilmiştir.
References
- 1. Dietrich AM, Bowman MJ, Ginn-Pease ME, Kosnik E, King DR. Pediatric head injuries: can clinical factors reliably predict an abnormality on computed tomography? Ann Emerg Med 1993;22:1535-40.
- 2. Gruskin KD, Schutzman SA. Head trauma in children younger than 2 years: are there predictors for complications? Arch Pediatr Adolesc Med 1999; 153:15-20.
- 3. Schunk JE, Rodgerson JD, Woodward GA. The utility of head computed tomographic scanning in pediatric patients with normal neurologic examination in the emergency department. Pediatr Emerg Care 1996;12:160-5.
- 4. Quayle KS, Jaffe DM, Kuppermann N, Kaufman BA, Lee BC, Park TS, et al. Diagnostic testing for acute head injury in children: when are head computed tomography and skull radiographs indicated? Pediatrics 1997;99:E11.
- 5. Ingebrigtsen T, Romner B, Kock-Jensen C. Scandinavian guidelines for initial management of minimal, mild, and moderate head injuries.The Scandinavian Neurotrauma Committee. J Trauma 2000;48:760-6.
- 6. Sosin DM, Sniezek JE, Waxweiler RJ. Trends in death associated with traumatic brain injury, 1979 through 1992. Success and failure. JAMA 1995;273:1778-80.
- 7. Taheri PA, Karamanoukian H, Gibbons K, Waldman N, Doerr RJ, Hoover EL. Can patients with minor head injuries be safely discharged home? Arch Surg 1993;128:289-92.
- 8. Stiell IG, Wells GA, Vandemheen K, Laupacis A, Brison R, Eisenhauer MA, et al. Variation in ED use of computed tomography for patients with minor head injury. Ann Emerg Med 1997;30:14-22.
- 9. Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995; 41:1819-28.
- 10. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
- 11. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11:81-128.
- 12. Woertgen C, Rothoerl RD, Metz C, Brawanski A. Comparison of clinical, radiologic, and serum marker as prognostic factors after severe head injury. J Trauma 1999;47:1126-30.
- 13. Poli-de-Figueiredo LF, Biberthaler P, Simao Filho C, Hauser C, Mutschler W, Jochum M. Measurement of S-100B for risk classification of victims sustaining minor head injury--first pilot study in Brazil. Clinics 2006;61:41-6.
- 14. Ustün ME, Gürbilek M, Ak A, Vatansev H, Duman A. Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma. Intensive Care Med 2001;27:264-8.
- 15. Kerman M, Cirak B, Ozguner MF, Dagtekin A, Sutcu R, Altuntas I, et al. Does melatonin protect or treat brain damage from traumatic oxidative stress? Exp Brain Res 2005;163:406-10.
- 16. Cirak B, Rousan N, Kocak A, Palaoglu O, Palaoglu S, Kilic K. Melatonin as a free radical scavenger in experimental head trauma. Pediatr Neurosurg 1999; 31:298-301.
- 17. Kavalci C, Pekdemir M, Durukan P, Ilhan N, Yildiz M, Serhatlioglu S, et al. The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma. Am J Emerg Med 2007;25:391-5.
- 18. Shaw GJ, Jauch EC, Zemlan FP. Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury. Ann Emerg Med 2002; 39:254-7.
- 19. Bramley R, Whitehouse RW, Taylor PM. The Canadian CT Head Rule for patients with minor head injury: consequences for radiology departments in the U.K. Clin Radiol 2002;57:151-2.
Abstract
Amaç: Malonildialdehid lipit peroksidasyonunun en duyarlı
göstergelerinden biridir. Bu çalışmada minör kafa travmalı
hastalarda serum malonildialdehid (MDA) seviyelerinin intrakraniyal
hasarın tanısındaki yerinin araştırılması amaçlanmıştır.
Hastalar ve Yöntemler: Çalışma Fırat Üniversitesi Tıp
Fakültesi Acil Servisinde prospektif olarak yapılmıştır.
Hastalar bilgisayarlı beyin tomografisinde lezyon olmayanlar
(grup 1) ve olanlar (grup 2) olarak iki gruba ayrıldı.
Serum MDA seviyeleri belirlendi.
Bulgular: Grup 1’deki (n=50) hastaların ortalama serum
MDA düzeyi 31.186±46.9 pg/ml, grup 2’deki (n=24) hastaların
ise 54.873±127.6 pg/ml idi. Yapılan istatistiksel analiz
sonucu bu iki grup arasında serum MDA düzeyleri açısından
istatistiksel olarak anlamlı bir fark bulunmadı (p > 0.05).
Sonuç: Minör kafa travmalı hastalarda serum MDA düzeylerinin
bilgisayarlı beyin tomografisi ile saptanan intrakraniyal
hasarı belirlemede etkili olmadığı tespit edilmiştir.
Keywords
References
- 1. Dietrich AM, Bowman MJ, Ginn-Pease ME, Kosnik E, King DR. Pediatric head injuries: can clinical factors reliably predict an abnormality on computed tomography? Ann Emerg Med 1993;22:1535-40.
- 2. Gruskin KD, Schutzman SA. Head trauma in children younger than 2 years: are there predictors for complications? Arch Pediatr Adolesc Med 1999; 153:15-20.
- 3. Schunk JE, Rodgerson JD, Woodward GA. The utility of head computed tomographic scanning in pediatric patients with normal neurologic examination in the emergency department. Pediatr Emerg Care 1996;12:160-5.
- 4. Quayle KS, Jaffe DM, Kuppermann N, Kaufman BA, Lee BC, Park TS, et al. Diagnostic testing for acute head injury in children: when are head computed tomography and skull radiographs indicated? Pediatrics 1997;99:E11.
- 5. Ingebrigtsen T, Romner B, Kock-Jensen C. Scandinavian guidelines for initial management of minimal, mild, and moderate head injuries.The Scandinavian Neurotrauma Committee. J Trauma 2000;48:760-6.
- 6. Sosin DM, Sniezek JE, Waxweiler RJ. Trends in death associated with traumatic brain injury, 1979 through 1992. Success and failure. JAMA 1995;273:1778-80.
- 7. Taheri PA, Karamanoukian H, Gibbons K, Waldman N, Doerr RJ, Hoover EL. Can patients with minor head injuries be safely discharged home? Arch Surg 1993;128:289-92.
- 8. Stiell IG, Wells GA, Vandemheen K, Laupacis A, Brison R, Eisenhauer MA, et al. Variation in ED use of computed tomography for patients with minor head injury. Ann Emerg Med 1997;30:14-22.
- 9. Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995; 41:1819-28.
- 10. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
- 11. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11:81-128.
- 12. Woertgen C, Rothoerl RD, Metz C, Brawanski A. Comparison of clinical, radiologic, and serum marker as prognostic factors after severe head injury. J Trauma 1999;47:1126-30.
- 13. Poli-de-Figueiredo LF, Biberthaler P, Simao Filho C, Hauser C, Mutschler W, Jochum M. Measurement of S-100B for risk classification of victims sustaining minor head injury--first pilot study in Brazil. Clinics 2006;61:41-6.
- 14. Ustün ME, Gürbilek M, Ak A, Vatansev H, Duman A. Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma. Intensive Care Med 2001;27:264-8.
- 15. Kerman M, Cirak B, Ozguner MF, Dagtekin A, Sutcu R, Altuntas I, et al. Does melatonin protect or treat brain damage from traumatic oxidative stress? Exp Brain Res 2005;163:406-10.
- 16. Cirak B, Rousan N, Kocak A, Palaoglu O, Palaoglu S, Kilic K. Melatonin as a free radical scavenger in experimental head trauma. Pediatr Neurosurg 1999; 31:298-301.
- 17. Kavalci C, Pekdemir M, Durukan P, Ilhan N, Yildiz M, Serhatlioglu S, et al. The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma. Am J Emerg Med 2007;25:391-5.
- 18. Shaw GJ, Jauch EC, Zemlan FP. Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury. Ann Emerg Med 2002; 39:254-7.
- 19. Bramley R, Whitehouse RW, Taylor PM. The Canadian CT Head Rule for patients with minor head injury: consequences for radiology departments in the U.K. Clin Radiol 2002;57:151-2.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | March 1, 2008 |
| Published in Issue | Year 2008 Volume: 2008 Issue: 3 |