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Serum Homocysteine and Lipoprotein(a) Levels in Preeclamptic Pregnants

Year 2009, Volume: 2009 Issue: 3, 208 - 213, 01.03.2009

Abstract

Objectives: The etiopathogenesis of preeclampsia has been shown to include the existence of vascular damage with endothelial dysfunction being the most directly related with development of the disorder. Elevated total homocysteine and lipoprotein(a) are risk factors for endothelial dysfunction and vascular diseases. We compared serum total homocysteine and lipoprotein(a) levels in healthy pregnant women and preeclamptics and investigated the relationship between these parameters. Patients and Methods: Total homocysteine and lipoprotein(a) levels in serum of 28 women with preeclampsia and 25 normotensive women were measured by chemiluminescence and enzyme-linked immunosorbent assay methods, respectively. Both groups were composed of third trimester pregnants. Results: Concentrations of total homocysteine (µmol/L) were significantly higher in women with preeclampsia than in normotensive pregnants. [8.54±4.76 vs. 4.85±1.50, (mean±standart deviation), respectively; p<0.001]. But no significant difference in lipoprotein(a) values (mg/dL) was observed in preeclamptics compared with matched healthy pregnants (Geometric mean: 4.15 mg/dL in preeclampsia vs. 2.30 mg/dL in controls). Conclusion: There is a 1.8 fold increase in serum total homocysteine in preeclampsia compared to normotensive pregnants, which may cause vascular endothelial dysfunction. Circulating lipoprotein(a) is not significantly elevated in preeclamptics and thus is unlikely to play a role in the pathophysiology of this disorder. Turkish Başlık: Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri Anahtar Kelimeler: Preeklampsi; homosistein, lipoprotein(a) Amaç: Preeklampsinin etyopatogenezinde, hastalığın gelişimi ile doğrudan ilişkili olan endotel disfonksiyonu ile birlikte vasküler hasarın varlığı gösterilmiştir. Yüksek total homosistein ve lipoprotein(a), endotelyal disfonksiyon ve vasküler hastalıklar için risk faktörleridir. Bu çalışmanın amacı sağlıklı ve preeklamptik gebe kadınlarda serum total homosistein ve lipoprotein(a) düzeylerini karşılaştırmak ve aralarındaki ilişkiyi araştırmaktır. Hastalar ve Yöntemler: Yirmi sekiz preeklampsili ve 25 normotansif kadının serumunda total homosistein ve lipoprotein(a) düzeyleri sırası ile kemilüminesans ve enzim bağlı immünosorbent ölçüm yöntemleri ile tayin edildi. Her iki grup da 3. trimesterdeki gebelerden oluşturuldu. Bulgular: Total homosistein konsantrasyonları (µmol/L) preeklampsili kadınlarda normotansif gebelerden anlamlı derecede yüksek bulundu [sırası ile, 8.54±4.76; 4.85±1.50, (ortalama±standart sapma); p<0.001]. Fakat preeklamptiklerde gözlenen lipoprotein(a) değerleri (mg/dL) sağlıklı gebelere kıyasla önemli derecede farklılık göstermedi (Geometrik ortalama: preeklamptiklerde, 4.15 mg/dL; kontrollerde 2.30 mg/dL). Sonuç: Preeklampside serum total homosistein düzeyinde normotansif gebelere kıyasla 1.8 kat artış vardır. Bu artış vasküler endotelyal disfonksiyona yol açabilir. Dolaşımdaki lipoprotein(a) preeklamptiklerde önemli bir yükselme göstermediğinden, bu hastalığın patofizyolojisinde rol oynamadığı görülmektedir.

References

  • Laivuori H, Kaaja R, Turpeinen U, Viinikka L, Ylikorkala O. Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preec- lampsia. Obstet Gynecol 1999;93:489-93.
  • Rajkovic A, Catalano PM, Malinow MR. Elevated homocyst(e)ine levels with preeclampsia. Obstet Gynecol 1997;90:168-71.
  • Wang J, Trudinger BJ, Duarte N, Wilcken DE, Wang XL. Elevated circulating homocyst(e)ine levels in pla- cental vascular disease and associated pre-eclampsia. BJOG 2000;107:935-8.
  • Sanchez SE, Zhang C, Rene Malinow M, Ware- Jauregui S, Larrabure G, Williams MA. Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol 2001;153:474-80.
  • Vanderjagt DJ, Patel RJ, El-Nafaty AU, Melah GS, Crossey MJ, Glew RH. High-density lipoprotein and homocysteine levels correlate inversely in preec- lamptic women in northern Nigeria. Acta Obstet Gynecol Scand 2004;83:536-42.
  • Ophir E, Dourleshter G, Hirsh Y, Fait V, German L, Bornstein J. Newborns of pre-eclamptic women: a biochemical difference present in utero. Acta Obstet Gynecol Scand 2006;85:1172-8.
  • Mayerhofer K, Hefler L, Zeisler H, Tempfer C, Bodner K, Stöckler-Ipsiroglu S, et al. Serum homocyst(e) ine levels in women with preeclampsia. Wien Klin Wochenschr 2000;112:271-5.
  • Chauveau P, Chadefaux B, Coudé M,
  • Aupetit J, Hannedouche T, Kamoun P, et al. Hyperhomocysteinemia, a risk factor for atheroscle- rosis in chronic uremic patients. Kidney Int Suppl 1993;41:S72-7.
  • Malinow MR, Rajkovic A, Duell PB, Hess DL, Upson BM. The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism. Am J Obstet Gynecol 1998;178:228-33.
  • Wang J, Mimuro S, Lahoud R, Trudinger B, Wang XL. Elevated levels of lipoprotein(a) in women with preeclampsia. Am J Obstet Gynecol 1998;178:146-9.
  • Kamiński K, Czuba B, Fiegler P. Predictive useful- ness of lipoproteins a -Lp (a) in cases of preeclamp- sia. Ginekol Pol 2000;71:777-82. [Abstract]
  • Djurovic S, Schjetlein R, Wislİff F, Haugen G, Husby H, Berg K. Plasma concentrations of Lp(a) lipopro- tein and TGF-beta1 are altered in preeclampsia. Clin Genet 1997;52:371-6.
  • Bayhan G, Koçyigit Y, Atamer A, Atamer Y, Akkus Z. Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia. Gynecol Endocrinol 2005;21:1-6.
  • Sattar N, Clark P, Greer IA, Shepherd J, Packard CJ. Lipoprotein (a) levels in normal pregnancy and in pregnancy complicated with pre-eclampsia. Atherosclerosis 2000;148:407-11.
  • Nagy B, Rigó J Jr, Fintor L, Romics L, Papp Z, Karádi I. Distribution of apolipoprotein(a) isoforms in nor- motensive and severe preeclamptic women. J Matern Fetal Med 1999;8:270-4.
  • Belo L, Caslake M, Santos-Silva A, Pereira-Leite L, Quintanilha A, Rebelo I. Lipoprotein(a): a longitu- dinal versus a cross-sectional study in normal preg- nancy and its levels in preeclampsia. Atherosclerosis 2002;165:393-5.
  • Murakami M, Okuyama T, Tokuoka S, Horie M, Saeki H, Abe M. Changes in serum lipoprotein (a) levels related to hyperlipidemia during pregnan- cy--comparing normal pregnancy and toxemia of pregnancy. Nippon Sanka Fujinka Gakkai Zasshi 1996;48:177-83. [Abstract]
  • Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro EB, et al. Fetal lipoprotein changes in pre- eclampsia. Acta Obstet Gynecol Scand 2008;87:628-34.
  • Var A, Kuşcu NK, Koyuncu F, Uyanik BS, Onur E, Yildirim Y, et al. Atherogenic profile in preeclampsia. Arch Gynecol Obstet 2003;268:45-7.
  • Baksu B, Baksu A, Davas I, Akyol A, Gülbaba G. Lipoprotein(a) levels in women with pre-eclampsia and in normotensive pregnant women. J Obstet Gynaecol Res 2005;31:277-82.

Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri

Year 2009, Volume: 2009 Issue: 3, 208 - 213, 01.03.2009

Abstract

Amaç: Preeklampsinin etyopatogenezinde, hastalığın
gelişimi ile doğrudan ilişkili olan endotel disfonksiyonu
ile birlikte vasküler hasarın varlığı gösterilmiştir.
Yüksek total homosistein ve lipoprotein(a), endotelyal
disfonksiyon ve vasküler hastalıklar için risk faktörleridir.
Bu çalışmanın amacı sağlıklı ve preeklamptik gebe
kadınlarda serum total homosistein ve lipoprotein(a)
düzeylerini karşılaştırmak ve aralarındaki ilişkiyi araş-
tırmaktır.
Hastalar ve Yöntemler: Yirmi sekiz preeklampsili ve
25 normotansif kadının serumunda total homosistein
ve lipoprotein(a) düzeyleri sırası ile kemilüminesans ve
enzim bağlı immünosorbent ölçüm yöntemleri ile tayin
edildi. Her iki grup da 3. trimesterdeki gebelerden oluş-
turuldu.
Bulgular: Total homosistein konsantrasyonları (μmol/L)
preeklampsili kadınlarda normotansif gebelerden anlamlı
derecede yüksek bulundu [sırası ile, 8.54±4.76;
4.85±1.50, (ortalama±standart sapma); p

References

  • Laivuori H, Kaaja R, Turpeinen U, Viinikka L, Ylikorkala O. Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preec- lampsia. Obstet Gynecol 1999;93:489-93.
  • Rajkovic A, Catalano PM, Malinow MR. Elevated homocyst(e)ine levels with preeclampsia. Obstet Gynecol 1997;90:168-71.
  • Wang J, Trudinger BJ, Duarte N, Wilcken DE, Wang XL. Elevated circulating homocyst(e)ine levels in pla- cental vascular disease and associated pre-eclampsia. BJOG 2000;107:935-8.
  • Sanchez SE, Zhang C, Rene Malinow M, Ware- Jauregui S, Larrabure G, Williams MA. Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol 2001;153:474-80.
  • Vanderjagt DJ, Patel RJ, El-Nafaty AU, Melah GS, Crossey MJ, Glew RH. High-density lipoprotein and homocysteine levels correlate inversely in preec- lamptic women in northern Nigeria. Acta Obstet Gynecol Scand 2004;83:536-42.
  • Ophir E, Dourleshter G, Hirsh Y, Fait V, German L, Bornstein J. Newborns of pre-eclamptic women: a biochemical difference present in utero. Acta Obstet Gynecol Scand 2006;85:1172-8.
  • Mayerhofer K, Hefler L, Zeisler H, Tempfer C, Bodner K, Stöckler-Ipsiroglu S, et al. Serum homocyst(e) ine levels in women with preeclampsia. Wien Klin Wochenschr 2000;112:271-5.
  • Chauveau P, Chadefaux B, Coudé M,
  • Aupetit J, Hannedouche T, Kamoun P, et al. Hyperhomocysteinemia, a risk factor for atheroscle- rosis in chronic uremic patients. Kidney Int Suppl 1993;41:S72-7.
  • Malinow MR, Rajkovic A, Duell PB, Hess DL, Upson BM. The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism. Am J Obstet Gynecol 1998;178:228-33.
  • Wang J, Mimuro S, Lahoud R, Trudinger B, Wang XL. Elevated levels of lipoprotein(a) in women with preeclampsia. Am J Obstet Gynecol 1998;178:146-9.
  • Kamiński K, Czuba B, Fiegler P. Predictive useful- ness of lipoproteins a -Lp (a) in cases of preeclamp- sia. Ginekol Pol 2000;71:777-82. [Abstract]
  • Djurovic S, Schjetlein R, Wislİff F, Haugen G, Husby H, Berg K. Plasma concentrations of Lp(a) lipopro- tein and TGF-beta1 are altered in preeclampsia. Clin Genet 1997;52:371-6.
  • Bayhan G, Koçyigit Y, Atamer A, Atamer Y, Akkus Z. Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia. Gynecol Endocrinol 2005;21:1-6.
  • Sattar N, Clark P, Greer IA, Shepherd J, Packard CJ. Lipoprotein (a) levels in normal pregnancy and in pregnancy complicated with pre-eclampsia. Atherosclerosis 2000;148:407-11.
  • Nagy B, Rigó J Jr, Fintor L, Romics L, Papp Z, Karádi I. Distribution of apolipoprotein(a) isoforms in nor- motensive and severe preeclamptic women. J Matern Fetal Med 1999;8:270-4.
  • Belo L, Caslake M, Santos-Silva A, Pereira-Leite L, Quintanilha A, Rebelo I. Lipoprotein(a): a longitu- dinal versus a cross-sectional study in normal preg- nancy and its levels in preeclampsia. Atherosclerosis 2002;165:393-5.
  • Murakami M, Okuyama T, Tokuoka S, Horie M, Saeki H, Abe M. Changes in serum lipoprotein (a) levels related to hyperlipidemia during pregnan- cy--comparing normal pregnancy and toxemia of pregnancy. Nippon Sanka Fujinka Gakkai Zasshi 1996;48:177-83. [Abstract]
  • Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro EB, et al. Fetal lipoprotein changes in pre- eclampsia. Acta Obstet Gynecol Scand 2008;87:628-34.
  • Var A, Kuşcu NK, Koyuncu F, Uyanik BS, Onur E, Yildirim Y, et al. Atherogenic profile in preeclampsia. Arch Gynecol Obstet 2003;268:45-7.
  • Baksu B, Baksu A, Davas I, Akyol A, Gülbaba G. Lipoprotein(a) levels in women with pre-eclampsia and in normotensive pregnant women. J Obstet Gynaecol Res 2005;31:277-82.
There are 21 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Murat Yaşar Işıldak This is me

Sembol Türkmen Yıldırmak This is me

Serkan Doğan This is me

Mustafa Çakmak This is me

Mustafa Çakmak This is me

Ekrem Özakın This is me

Publication Date March 1, 2009
Published in Issue Year 2009 Volume: 2009 Issue: 3

Cite

APA Işıldak, M. Y., Yıldırmak, S. T., Doğan, S., Çakmak, M., et al. (2009). Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri. Balkan Medical Journal, 2009(3), 208-213.
AMA Işıldak MY, Yıldırmak ST, Doğan S, Çakmak M, Çakmak M, Özakın E. Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri. Balkan Medical Journal. March 2009;2009(3):208-213.
Chicago Işıldak, Murat Yaşar, Sembol Türkmen Yıldırmak, Serkan Doğan, Mustafa Çakmak, Mustafa Çakmak, and Ekrem Özakın. “Preeklamptik Gebelerde Serum Homosistein Ve Lipoprotein(a) Düzeyleri”. Balkan Medical Journal 2009, no. 3 (March 2009): 208-13.
EndNote Işıldak MY, Yıldırmak ST, Doğan S, Çakmak M, Çakmak M, Özakın E (March 1, 2009) Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri. Balkan Medical Journal 2009 3 208–213.
IEEE M. Y. Işıldak, S. T. Yıldırmak, S. Doğan, M. Çakmak, M. Çakmak, and E. Özakın, “Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri”, Balkan Medical Journal, vol. 2009, no. 3, pp. 208–213, 2009.
ISNAD Işıldak, Murat Yaşar et al. “Preeklamptik Gebelerde Serum Homosistein Ve Lipoprotein(a) Düzeyleri”. Balkan Medical Journal 2009/3 (March 2009), 208-213.
JAMA Işıldak MY, Yıldırmak ST, Doğan S, Çakmak M, Çakmak M, Özakın E. Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri. Balkan Medical Journal. 2009;2009:208–213.
MLA Işıldak, Murat Yaşar et al. “Preeklamptik Gebelerde Serum Homosistein Ve Lipoprotein(a) Düzeyleri”. Balkan Medical Journal, vol. 2009, no. 3, 2009, pp. 208-13.
Vancouver Işıldak MY, Yıldırmak ST, Doğan S, Çakmak M, Çakmak M, Özakın E. Preeklamptik Gebelerde Serum Homosistein ve Lipoprotein(a) Düzeyleri. Balkan Medical Journal. 2009;2009(3):208-13.