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Helicobacter Pylori Infection and Benign Gastroduodenal Diseases, Data from the Trakya Region

Year 2010, Volume: 2010 Issue: 5, 400 - 403, 01.05.2010

Hasan Ümit Gülbin Ünsal Ahmet Tezel Ali Rıza Soylu

https://doi.org/10.5174/tutfd.2009.02159.1

Abstract

Objective: Helicobacter pylori (H. pylori) is implicated in the etiology of gastric and duodenal ulcer, non-ulcer dyspepsia, atrophic gastritis, gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma (MALToma). The aim of our study is to evaluate the prevalance of H. pylori infection in patients with benign gastroduodenal diseases. Material and Methods: H. pylori infection was evaluated retrospectively with the urease test in 4714 patients with benign gastroduodenal disorders who applied to the endoscopy unit of Trakya University Hospital, the only University hospital in the Trakya region, between November 2003 and October 2007 with dyspeptic complaints. Results: Overall, the rapid urease test was positive in 52.8% of cases. Helicobacter pylori was positive in 65% of the bulbar ulcer, 61% of the erosive bulbitis, 60.2% of the gastric ulcer and, 48.4% of the gastritis patients. (p<0.001). H. pylori positivity was 52% in Trakya born patients, 56.3% in immigrants from Anatolia and 48.7% in immigrants from Europe (p=0.02). H. pylori positivity frequencies in women and men were 52.2% and 53.2%, respectively (p=0.52). Urease test positivity was significantly more frequent in patients 30-60 years of age compared to the groups younger than 30 or older than 60. Conclusion: The epidemiologic characteristics of H. pylori infection shows features of both Turkey and neighbouring countries of Europe Turkish Başlık: Helikobakter Pilori İnfeksiyonu ve Benign Gastroduodenal Hastalıklar, Trakya Bölgesi Verileri Anahtar Kelimeler: Helikobakter pilori infeksiyonu; epidemiyoloji; peptik ülser hastalığı Amaç: Helikobakter pilori (H. pilori) gastrik ve duodenal ülser, non-ülser dispepsi, atrofik gastrit, mide kanseri ve MALT lenfoması etiyolojisinde rol oynamaktadır. Çalışmamızda Trakya bölgesinde beniğn gastroduodenal hastalıklarda H. pilori infeksiyonu prevelansı araştırılmıştır. Gereç ve Yöntemler: Trakya Üniversitesi Tıp Fakültesi Endoskopi Ünitesine başvuran ve beniğn gastroduodenal hastalıklar saptanan 4714 hastada retrospektif olarak H. pilori infeksiyonu prevelansı araştırıldı. Bulgular: Hastaların %52.8'inde H. pilori pozitif saptandı. H. pilori bulber ülser hastalarında %65, gastrik ülserli hastalarda %60.2, gastritli hastalarda ise %48.4 oranında pozitif bulundu (p<0.001). Trakya bölgesi kökenli hastaların %52'sinde, Anadoludan göç eden hastaların %56.3'ünde, Avrupadan göç eden hastaların %48.7'sinde H. pilori pozitif bulundu (p=0.02). Helikobakter pilori kadınlarda %53.2, erkeklerde %52.2 oranında pozitifti (p=0.52). Üreaz pozitifliği 30-60 arasındaki hastalarda 30 yaşından küçükler ve 60 yaşından büyüklere göre daha fazlaydı. Sonuç: Trakya bölgesinde H. pilori infeksiyonu hem ülkemizin diğer bölgeleri ile hemde komşu avrupa ülkeleri ile benzer epidemiyolojik özellikler göstermektedir.

Keywords

Helicobacter pylori infection; epidemiology; peptic ulcer disease

References

  • Drumm B, Sherman P, Cutz E, Karmali M. Association of campylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med 1987;316:1557-61.
  • Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989;96:615-25.
  • Nih consensus conference. Helicobacter pylori in peptic ulcer disease. Nih consensus development panel on helicobacter pylori in peptic ulcer disease. JAMA 1994;272:65-9.
  • Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al. Regression of primary low-grade b-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of helicobacter pylori. Lancet 1993;342:575-7.
  • Megraud F. Epidemiology of helicobacter pylori infection. Gastroenterol Clin North Am 1993;22:73-88.
  • Williams MP, Pounder RE. Helicobacter pylori: From the benign to the malignant. Am J Gastroenterol 1999;94:S11-6.
  • Kumagai T, Malaty HM, Graham DY, Hosogaya S, Misawa K, Furihata K, Ota H, Sei C, Tanaka E, Akamatsu T, Shimizu T, Kiyosawa K, Katsuyama T. Acquisition versus loss of helicobacter pylori infection in japan: Results from an 8-year birth cohort study. J Infect Dis 1998;178:717-21.
  • Malaty HM, Graham DY, Wattigney WA, Srinivasan SR, Osato M, Berenson GS. Natural history of helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community. Clin Infect Dis 1999;28:279-82.
  • Malaty HM, Kumagai T, Tanaka E, Ota H, Kiyosawa K, Graham DY, et al. Evidence from a nine-year birth cohort study in japan of transmission pathways of helicobacter pylori infection. J Clin Microbiol 2000;38:1971-3.
  • Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, et al. Age at acquisition of helicobacter pylori infection: A follow-up study from infancy to adulthood. Lancet 2002;359:931-5.
  • Ozen A, Ertem D, Pehlivanoglu E. Natural history and symptomatology of helicobacter pylori in childhood and factors determining the epidemiology of infection. J Pediatr Gastroenterol Nutr 2006;42:398-404.
  • Lin CW, Wang HH, Chang YF, Cheng KS. Evaluation of clo test and polymerase chain reaction for biopsy-dependent diagnosis of helicobacter pylori infection. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1997;30:219-27.
  • Hahn M, Fennerty MB, Corless CL, Magaret N, Lieberman DA, Faigel DO. Noninvasive tests as a substitute for histology in the diagnosis of helicobacter pylori infection. Gastrointest Endosc 2000;52:20-6.
  • Cutler AF, Havstad S, Ma CK, Blaser MJ, Perez-Perez GI, Schubert TT. Accuracy of invasive and noninvasive tests to diagnose helicobacter pylori infection. Gastroenterology 1995;109:136-41.
  • Puetz T, Vakil N, Phadnis S, Dunn B, Robinson J. The pyloritek test and the clo test: Accuracy and incremental cost analysis. Am J Gastroenterol 1997;92:254-7.
  • Ohara S, Kato M, Asaka M, Toyota T. Studies of 13c-urea breath test for diagnosis of helicobacter pylori infection in japan. J Gastroenterol 1998;33:6-13.
  • Archimandritis A, Apostolopoulos P, Sougioultzis S, Delladetsima I, Davaris P, Tzivras M. The clo test is unreliable in diagnosing h. Pylori infection in post-surgical stomach; is there any role of h. Pylori in peptic ulcer recurrence? Eur J Gastroenterol Hepatol 2000;12:93-6.
  • Ozden A, Bozdayi G, Ozkan M, Kose KS. Changes in the seroepidemiological pattern of helicobacter pylori infection over the last 10 years. Turk J Gastroenterol 2004;15:156-8.
  • Apostolopoulos P, Vafiadis-Zouboulis I, Tzivras M, Kourtessas D, Katsilambros N, Archimandritis A. Helicobacter pylori (h pylori) infection in greece: The changing prevalence during a ten-year period and its antigenic profile. BMC Gastroenterol 2002;2:11.
  • Boyanova L, Koumanova R, Jelev C, Petrov S. Helicobacters in bulgarian children. J R Soc Med 1997;90:588-9.

Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri

Year 2010, Volume: 2010 Issue: 5, 400 - 403, 01.05.2010

Hasan Ümit Gülbin Ünsal Ahmet Tezel Ali Rıza Soylu

https://doi.org/10.5174/tutfd.2009.02159.1

Abstract

Amaç: Helikobakter pilori (H. pilori) gastrik ve duodenal ülser, non-ülser dispepsi, atrofik gastrit, mide kanseri ve MALT lenfoması etiyolojisinde rol oynamaktadır. Çalışmamızda Trakya bölgesinde beniğn gastroduodenal hastalıklarda H. pilori infeksiyonu prevelansı araştırılmıştır. Gereç ve Yöntemler: Trakya Üniversitesi Tıp Fakültesi Endoskopi Ünitesine başvuran ve beniğn gastroduodenal hastalıklar saptanan 4714 hastada retrospektif olarak H. pilori infeksiyonu prevelansı araştırıldı. Bulgular: Hastaların %52.8'inde H. pilori pozitif saptandı. H. pilori bulber ülser hastalarında %65, gastrik ülserli hastalarda %60.2, gastritli hastalarda ise %48.4 oranında pozitif bulundu (p<0.001). Trakya bölgesi kökenli hastaların %52'sinde, Anadoludan göç eden hastaların %56.3'ünde, Avrupadan göç eden hastaların %48.7'sinde H. pilori pozitif bulundu (p=0.02). Helikobakter pilori kadınlarda %53.2, erkeklerde %52.2 oranında pozitifti (p=0.52). Üreaz pozitifliği 30-60 arasındaki hastalarda 30 yaşından küçükler ve 60 yaşından büyüklere göre daha fazlaydı. Sonuç: Trakya bölgesinde H. pilori infeksiyonu hem ülkemizin diğer bölgeleri ile hemde komşu avrupa ülkeleri ile benzer epidemiyolojik özellikler göstermektedir.

Keywords

Helikobakter pilori infeksiyonu epidemiyoloji peptik ülser hastalığı

References

  • Drumm B, Sherman P, Cutz E, Karmali M. Association of campylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med 1987;316:1557-61.
  • Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989;96:615-25.
  • Nih consensus conference. Helicobacter pylori in peptic ulcer disease. Nih consensus development panel on helicobacter pylori in peptic ulcer disease. JAMA 1994;272:65-9.
  • Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al. Regression of primary low-grade b-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of helicobacter pylori. Lancet 1993;342:575-7.
  • Megraud F. Epidemiology of helicobacter pylori infection. Gastroenterol Clin North Am 1993;22:73-88.
  • Williams MP, Pounder RE. Helicobacter pylori: From the benign to the malignant. Am J Gastroenterol 1999;94:S11-6.
  • Kumagai T, Malaty HM, Graham DY, Hosogaya S, Misawa K, Furihata K, Ota H, Sei C, Tanaka E, Akamatsu T, Shimizu T, Kiyosawa K, Katsuyama T. Acquisition versus loss of helicobacter pylori infection in japan: Results from an 8-year birth cohort study. J Infect Dis 1998;178:717-21.
  • Malaty HM, Graham DY, Wattigney WA, Srinivasan SR, Osato M, Berenson GS. Natural history of helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community. Clin Infect Dis 1999;28:279-82.
  • Malaty HM, Kumagai T, Tanaka E, Ota H, Kiyosawa K, Graham DY, et al. Evidence from a nine-year birth cohort study in japan of transmission pathways of helicobacter pylori infection. J Clin Microbiol 2000;38:1971-3.
  • Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, et al. Age at acquisition of helicobacter pylori infection: A follow-up study from infancy to adulthood. Lancet 2002;359:931-5.
  • Ozen A, Ertem D, Pehlivanoglu E. Natural history and symptomatology of helicobacter pylori in childhood and factors determining the epidemiology of infection. J Pediatr Gastroenterol Nutr 2006;42:398-404.
  • Lin CW, Wang HH, Chang YF, Cheng KS. Evaluation of clo test and polymerase chain reaction for biopsy-dependent diagnosis of helicobacter pylori infection. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1997;30:219-27.
  • Hahn M, Fennerty MB, Corless CL, Magaret N, Lieberman DA, Faigel DO. Noninvasive tests as a substitute for histology in the diagnosis of helicobacter pylori infection. Gastrointest Endosc 2000;52:20-6.
  • Cutler AF, Havstad S, Ma CK, Blaser MJ, Perez-Perez GI, Schubert TT. Accuracy of invasive and noninvasive tests to diagnose helicobacter pylori infection. Gastroenterology 1995;109:136-41.
  • Puetz T, Vakil N, Phadnis S, Dunn B, Robinson J. The pyloritek test and the clo test: Accuracy and incremental cost analysis. Am J Gastroenterol 1997;92:254-7.
  • Ohara S, Kato M, Asaka M, Toyota T. Studies of 13c-urea breath test for diagnosis of helicobacter pylori infection in japan. J Gastroenterol 1998;33:6-13.
  • Archimandritis A, Apostolopoulos P, Sougioultzis S, Delladetsima I, Davaris P, Tzivras M. The clo test is unreliable in diagnosing h. Pylori infection in post-surgical stomach; is there any role of h. Pylori in peptic ulcer recurrence? Eur J Gastroenterol Hepatol 2000;12:93-6.
  • Ozden A, Bozdayi G, Ozkan M, Kose KS. Changes in the seroepidemiological pattern of helicobacter pylori infection over the last 10 years. Turk J Gastroenterol 2004;15:156-8.
  • Apostolopoulos P, Vafiadis-Zouboulis I, Tzivras M, Kourtessas D, Katsilambros N, Archimandritis A. Helicobacter pylori (h pylori) infection in greece: The changing prevalence during a ten-year period and its antigenic profile. BMC Gastroenterol 2002;2:11.
  • Boyanova L, Koumanova R, Jelev C, Petrov S. Helicobacters in bulgarian children. J R Soc Med 1997;90:588-9.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Hasan Ümit This is me

Gülbin Ünsal This is me

Ahmet Tezel This is me

Ali Rıza Soylu This is me

Publication Date May 1, 2010
Published in Issue Year 2010 Volume: 2010 Issue: 5

Cite

APA Ümit, H., Ünsal, G., Tezel, A., Soylu, A. R. (2010). Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri. Balkan Medical Journal, 2010(5), 400-403. https://doi.org/10.5174/tutfd.2009.02159.1
AMA Ümit H, Ünsal G, Tezel A, Soylu AR. Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri. Balkan Medical Journal. May 2010;2010(5):400-403. doi:10.5174/tutfd.2009.02159.1
Chicago Ümit, Hasan, Gülbin Ünsal, Ahmet Tezel, and Ali Rıza Soylu. “Helikobakter Pilori únfeksiyonu Ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri”. Balkan Medical Journal 2010, no. 5 (May 2010): 400-403. https://doi.org/10.5174/tutfd.2009.02159.1.
EndNote Ümit H, Ünsal G, Tezel A, Soylu AR (May 1, 2010) Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri. Balkan Medical Journal 2010 5 400–403.
IEEE H. Ümit, G. Ünsal, A. Tezel, and A. R. Soylu, “Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri”, Balkan Medical Journal, vol. 2010, no. 5, pp. 400–403, 2010, doi: 10.5174/tutfd.2009.02159.1.
ISNAD Ümit, Hasan et al. “Helikobakter Pilori únfeksiyonu Ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri”. Balkan Medical Journal 2010/5 (May 2010), 400-403. https://doi.org/10.5174/tutfd.2009.02159.1.
JAMA Ümit H, Ünsal G, Tezel A, Soylu AR. Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri. Balkan Medical Journal. 2010;2010:400–403.
MLA Ümit, Hasan et al. “Helikobakter Pilori únfeksiyonu Ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri”. Balkan Medical Journal, vol. 2010, no. 5, 2010, pp. 400-3, doi:10.5174/tutfd.2009.02159.1.
Vancouver Ümit H, Ünsal G, Tezel A, Soylu AR. Helikobakter Pilori únfeksiyonu ve Benign Gastroduodenal Hastal×klar, Trakya Bölgesi Verileri. Balkan Medical Journal. 2010;2010(5):400-3.