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HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population

Year 2011, Volume: 2011 Issue: 4, 366 - 374, 01.04.2011

Gökay Bozkurt

https://doi.org/10.5174/tutfd.2010.03712.2

Abstract

Objective: In the United States of America (USA) population, several studies focusing on frequencies of HLA alleles and their haplotypes have been reported, but HLA data in the USA population living in Dallas, Texas, are reported here for the first time. The aim of this study was to investigate the distribution of HLA in the populations of African American, European American, and Hispanic of Dallas, Texas and its genetic relatedness to the USA populations. Material and Methods: We present the HLA data available from the Transplant Donor Program database of Southwestern Medical Center at the University of Texas at Dallas. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Americans residing in the USA is complemented by neighbor-joining dendrogram and correspondence analysis. Results: The results of our study reflect a predominance of European and also Asian rather than African Ancestry for the Hispanic sample, especially those living in South of USA. Conclusion: As new information, our study results show that the largest genetic distances between all USA groups were those of the African Americans compared with each of the other groups in four major races.

Keywords

African Americans European Americans hispanics haplotype frequency HLA Dallas Texas

References

  • U.S. Census Bureau: State & County QuickFacts [homepage on the internet]. c2009 [ up-dated 2009 Feb 20; cited 2009 Feb 27]. Avail- able from www. quickfacts.census.gov/qfd/ states/48000.html.
  • Legacies: A History Journal for Dallas and North Central Texas, Volume 03, Number 02, fall, 1991. Dallas Historical Society, Lega- cies: a History Journal for Dallas and North Central Texas, http:// texashistory.unt.edu/permalink/meta-pth-35119
  • U.S. Census Bureau: 2005-2007 American Community Survey, Data Profile, Texas [homepage on the internet]. c2009 [updated 2009 Feb 20; cited 2009 March 01]. Available from http://factfinder.cen- sus.gov/servlet/ADPTable?_bm=y&-geo_id=04000US48&-con- text= adp&-ds_name=ACS_2007_3YR_G00_&-tree_id=3307&-_ lang=en&-caller=geoselect&-format=
  • Cao K, Hollenbach J, Shi X, Shi W, Chopek M, Fernandez-Vina MA. Analysis of the frequencies of HLA-A, B, and C alleles and haplo- types in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Hum Immunol 2001:62:1009-30. [CrossRef]
  • Mori M, Beatty PG, Graves M, Boucher KM, Milford EL. HLA gene and haplotype frequencies in the North American population: the National Marrow Donor Program Donor Registry. Transplantation 1997;64:1017-27. [CrossRef]
  • Maiers M, Gragert L, Klitz W. High-resolution HLA alleles and haplotypes in the United States population. Human Immunology 2007;68:779-88. [CrossRef]
  • Tan JM, Zhou YC, Tang XD. The technology and clinical application of tissue matching. Beijing: People’s Medical Publishing House; 2002.
  • Dempster AP, Laird NM, Rubin DB. Maximum likelihood from in- complete data via the EM algorithm. J R Stat Soc B 1977;39:1.
  • Long JC, Williams RC, Urbanek M. An E-M algorithm and test- ing strategy for multiple-locus haplotypes. Am J Hum Genet 1995; 56:799-810.
  • Excoffier L, Laval G, Schneider S. Arlequin (version 3.0): an inte- grated software package for population genetics data analysis. Evol Bioinform Online 2007;1:47-50.
  • Guo SW, Thompson EA. Performing the exact test of Hardy–Wein- berg proportion for multiple alleles. Biometrics 1992;48: 361-72. [CrossRef]
  • Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 1987:4:406-25.
  • Nei M. Phylogenetic Analysis In Molecular Evolutionary Genetics. Annu. Rev. Genet. 1996. 30:371-403. [CrossRef]
  • Nei M. Analysis of gene diversity in subdivided populations. Proc Natl Acad Sci old U. S.A. 1973:70:3321-3.
  • Nei M, Tajima F, Tateno Y. Accuracy of estimated phylogenetic trees from molecular data. J Mol Evol 1983:19:153-70. [CrossRef]
  • SPSS for Windows, Rel. 11.0.1. 2001. Chicago: SPSS Inc.
  • Zachary AA, Steinberg AG, Bias WB, Leffell MS. The frequen- cies of HLA alleles and haplotypes and their distribution among donors and renal patients in the UNOS registry. Transplantation. 1996;62:272-83. [CrossRef]
  • Bertoni B, Budowle B, Sans M, Barton SA, Chakraborty R. Admix- ture in Hispanics: distribution of ancestral population contribu- tions in the Continental United States. Hum Biol 2003;75:1-11. [CrossRef]
  • Shen C, Zhu B, Liu M, Li S. Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi’an city in China. Croat Med J 2008;49:476-82. [CrossRef]

HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population

Year 2011, Volume: 2011 Issue: 4, 366 - 374, 01.04.2011

Gökay Bozkurt

https://doi.org/10.5174/tutfd.2010.03712.2

Abstract

References

  • U.S. Census Bureau: State & County QuickFacts [homepage on the internet]. c2009 [ up-dated 2009 Feb 20; cited 2009 Feb 27]. Avail- able from www. quickfacts.census.gov/qfd/ states/48000.html.
  • Legacies: A History Journal for Dallas and North Central Texas, Volume 03, Number 02, fall, 1991. Dallas Historical Society, Lega- cies: a History Journal for Dallas and North Central Texas, http:// texashistory.unt.edu/permalink/meta-pth-35119
  • U.S. Census Bureau: 2005-2007 American Community Survey, Data Profile, Texas [homepage on the internet]. c2009 [updated 2009 Feb 20; cited 2009 March 01]. Available from http://factfinder.cen- sus.gov/servlet/ADPTable?_bm=y&-geo_id=04000US48&-con- text= adp&-ds_name=ACS_2007_3YR_G00_&-tree_id=3307&-_ lang=en&-caller=geoselect&-format=
  • Cao K, Hollenbach J, Shi X, Shi W, Chopek M, Fernandez-Vina MA. Analysis of the frequencies of HLA-A, B, and C alleles and haplo- types in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Hum Immunol 2001:62:1009-30. [CrossRef]
  • Mori M, Beatty PG, Graves M, Boucher KM, Milford EL. HLA gene and haplotype frequencies in the North American population: the National Marrow Donor Program Donor Registry. Transplantation 1997;64:1017-27. [CrossRef]
  • Maiers M, Gragert L, Klitz W. High-resolution HLA alleles and haplotypes in the United States population. Human Immunology 2007;68:779-88. [CrossRef]
  • Tan JM, Zhou YC, Tang XD. The technology and clinical application of tissue matching. Beijing: People’s Medical Publishing House; 2002.
  • Dempster AP, Laird NM, Rubin DB. Maximum likelihood from in- complete data via the EM algorithm. J R Stat Soc B 1977;39:1.
  • Long JC, Williams RC, Urbanek M. An E-M algorithm and test- ing strategy for multiple-locus haplotypes. Am J Hum Genet 1995; 56:799-810.
  • Excoffier L, Laval G, Schneider S. Arlequin (version 3.0): an inte- grated software package for population genetics data analysis. Evol Bioinform Online 2007;1:47-50.
  • Guo SW, Thompson EA. Performing the exact test of Hardy–Wein- berg proportion for multiple alleles. Biometrics 1992;48: 361-72. [CrossRef]
  • Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 1987:4:406-25.
  • Nei M. Phylogenetic Analysis In Molecular Evolutionary Genetics. Annu. Rev. Genet. 1996. 30:371-403. [CrossRef]
  • Nei M. Analysis of gene diversity in subdivided populations. Proc Natl Acad Sci old U. S.A. 1973:70:3321-3.
  • Nei M, Tajima F, Tateno Y. Accuracy of estimated phylogenetic trees from molecular data. J Mol Evol 1983:19:153-70. [CrossRef]
  • SPSS for Windows, Rel. 11.0.1. 2001. Chicago: SPSS Inc.
  • Zachary AA, Steinberg AG, Bias WB, Leffell MS. The frequen- cies of HLA alleles and haplotypes and their distribution among donors and renal patients in the UNOS registry. Transplantation. 1996;62:272-83. [CrossRef]
  • Bertoni B, Budowle B, Sans M, Barton SA, Chakraborty R. Admix- ture in Hispanics: distribution of ancestral population contribu- tions in the Continental United States. Hum Biol 2003;75:1-11. [CrossRef]
  • Shen C, Zhu B, Liu M, Li S. Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi’an city in China. Croat Med J 2008;49:476-82. [CrossRef]
There are 19 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Gökay Bozkurt This is me

Publication Date April 1, 2011
Published in Issue Year 2011 Volume: 2011 Issue: 4

Cite

APA Bozkurt, G. (2011). HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population. Balkan Medical Journal, 2011(4), 366-374. https://doi.org/10.5174/tutfd.2010.03712.2
AMA Bozkurt G. HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population. Balkan Medical Journal. April 2011;2011(4):366-374. doi:10.5174/tutfd.2010.03712.2
Chicago Bozkurt, Gökay. “HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population”. Balkan Medical Journal 2011, no. 4 (April 2011): 366-74. https://doi.org/10.5174/tutfd.2010.03712.2.
EndNote Bozkurt G (April 1, 2011) HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population. Balkan Medical Journal 2011 4 366–374.
IEEE G. Bozkurt, “HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population”, Balkan Medical Journal, vol. 2011, no. 4, pp. 366–374, 2011, doi: 10.5174/tutfd.2010.03712.2.
ISNAD Bozkurt, Gökay. “HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population”. Balkan Medical Journal 2011/4 (April 2011), 366-374. https://doi.org/10.5174/tutfd.2010.03712.2.
JAMA Bozkurt G. HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population. Balkan Medical Journal. 2011;2011:366–374.
MLA Bozkurt, Gökay. “HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population”. Balkan Medical Journal, vol. 2011, no. 4, 2011, pp. 366-74, doi:10.5174/tutfd.2010.03712.2.
Vancouver Bozkurt G. HLA-A, -B and -DR Allele and Haplotype Frequencies in the European American, African American, and Hispanic Populations in Dallas, Texas: Relatedness to the North American Population. Balkan Medical Journal. 2011;2011(4):366-74.