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Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association

Year 2011, Volume: 2011 Issue: 4, 450 - 452, 01.04.2011
https://doi.org/10.5174/tutfd.2010.03637.1

Abstract

Sarcoidosis is a multisystem granulomatous disorder of unknown etiology and it may rarely be associated with a second disorder. Celiac disease is an immune-mediated enteropathy characterized with malabsorption caused by gluten intolerance, and several reports indicate an association between celiac disease and sarcoidosis. In addition, although celiac disease is associated with several extraintestinal pathologies, venous thrombosis has been rarely reported. Herein we present a rare case report of a patient with a diagnosis of sarcoidosis, celiac disease and deep venous thrombosis because of the rare association of these disorders. The patient was admitted with abdominal pain, weight loss, chronic diarrhea and a 5-day history of swelling in her right leg. A diagnosis of deep venous thrombosis was achieved by doppler ultrasonographic examination. The diagnosis of celiac disease was made by biopsy of duodenal mucosa and supported with elevated serum level of anti-gliadin IgA and IgG, and a diagnosis of sarcoidosis was achieved by transbronchial needle aspiration from the subcarinal lymph node during flexible bronchoscopy.

References

  • Statement on Sarcoidosis. Joint statement of the American Thoracic Society (ATS), European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Diseases (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160:736-55.
  • Rutherford RM, Brutsche MH, Kearns M, Bourke M, Stevens F, Gilmartin JJ. Prevalence of coeliac disease in patients with sarcoidosis. Eur J Gastroenterol Hepatol 2004;16:911-5. [CrossRef]
  • Papadopoulos K, Sjoberg K, Lindgren S, Hallengren B. Evidence of gastrointestinal immune reactivity in patients with sarcoidosis. J Intern Med 1999;245:525-31. [CrossRef]
  • Hwang E, McBride R, Neugut A, Gren HP. Sarcoidosis in Patients with Coeliac Disease. Dig Dis Sci 2008;53:977-81. [CrossRef]
  • Bianconcini G, Mazzali F, Candini R, Silingardi M, Lori I. Celiac disease (familial) associated with sarcoidosis. Clinical case and review of the literature. Minerva Med 1994;85:541-53.
  • Douglas JG, Gillon J, Logan RF, Grant IW, Crompton GK. Sarcoidosis and coeliac disease: an association? Lancet 1984;7;2:13-5. [CrossRef]
  • Gardner J, Kennedy HG, Hamblin A, Jones E. HLA associations in sarcoidosis: a study of 2 ethnic groups. Thorax 1984;39:19-22. [CrossRef]
  • Martinetti M, Tinelli C, Kolek V, Cuccia M, Salvaneschi L, Pasturenzi L, et al. ‘The sarcoidosis map’: a joint survey of clinical and immunogenetic findings in two European countries. Am J Respir Crit Care Med 1995;152:557-64.
  • Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993;105:910-22.
  • Ludvigsson JF, Welander A, Lassila R, Ekborn A, Monygomer SM. Risk of thromboembolism in 14,000 individuals with coeliac disease. Br J Haematol 2007;139:121-7.[CrossRef]
  • Kremer Hovinga JA, Baerlocher G, Wuillemin WA, Solenthaler M. Deep venous thrombosis of the leg in acquired thrombophiliahyperhomocysteinemia as a sequela of undetected coeliac disease. Ther Umsch 1999;56:519-22. [CrossRef]
  • Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, et al. Prevalance of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate and genetics. Clin Gastroenterol Hepatol 2005;3:574-80. [CrossRef]
  • Bahloul M, Chaari A, Khlaf-Bouaziz N, Kallel H, Chaari L, Ben Hamida C, et al. Coeliac disease cerebral venous thrombosis and protein S deficiency, a fortuitous associaton? J Mal Vasc 2005;30:228-30. [CrossRef]
  • Kallel L, Matri S, Karoui S, Fekih M, Boubaker J and Filali A. Deep Venous Thrombosis Related to Protein S Deficiency Revealing Celiac Disease. Am J Gastroenterol 2009;104:256-7. [CrossRef]
  • Ouakaa-Kchaou A, Ennaifer R, Belhadi N, Garoouri D, Elloumi H, Romani M, et al. Celiac disease associated with Budd-Chiari syndrome. Presse Med 2008;37:239-41.

Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association

Year 2011, Volume: 2011 Issue: 4, 450 - 452, 01.04.2011
https://doi.org/10.5174/tutfd.2010.03637.1

Abstract

References

  • Statement on Sarcoidosis. Joint statement of the American Thoracic Society (ATS), European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Diseases (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160:736-55.
  • Rutherford RM, Brutsche MH, Kearns M, Bourke M, Stevens F, Gilmartin JJ. Prevalence of coeliac disease in patients with sarcoidosis. Eur J Gastroenterol Hepatol 2004;16:911-5. [CrossRef]
  • Papadopoulos K, Sjoberg K, Lindgren S, Hallengren B. Evidence of gastrointestinal immune reactivity in patients with sarcoidosis. J Intern Med 1999;245:525-31. [CrossRef]
  • Hwang E, McBride R, Neugut A, Gren HP. Sarcoidosis in Patients with Coeliac Disease. Dig Dis Sci 2008;53:977-81. [CrossRef]
  • Bianconcini G, Mazzali F, Candini R, Silingardi M, Lori I. Celiac disease (familial) associated with sarcoidosis. Clinical case and review of the literature. Minerva Med 1994;85:541-53.
  • Douglas JG, Gillon J, Logan RF, Grant IW, Crompton GK. Sarcoidosis and coeliac disease: an association? Lancet 1984;7;2:13-5. [CrossRef]
  • Gardner J, Kennedy HG, Hamblin A, Jones E. HLA associations in sarcoidosis: a study of 2 ethnic groups. Thorax 1984;39:19-22. [CrossRef]
  • Martinetti M, Tinelli C, Kolek V, Cuccia M, Salvaneschi L, Pasturenzi L, et al. ‘The sarcoidosis map’: a joint survey of clinical and immunogenetic findings in two European countries. Am J Respir Crit Care Med 1995;152:557-64.
  • Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993;105:910-22.
  • Ludvigsson JF, Welander A, Lassila R, Ekborn A, Monygomer SM. Risk of thromboembolism in 14,000 individuals with coeliac disease. Br J Haematol 2007;139:121-7.[CrossRef]
  • Kremer Hovinga JA, Baerlocher G, Wuillemin WA, Solenthaler M. Deep venous thrombosis of the leg in acquired thrombophiliahyperhomocysteinemia as a sequela of undetected coeliac disease. Ther Umsch 1999;56:519-22. [CrossRef]
  • Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, et al. Prevalance of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate and genetics. Clin Gastroenterol Hepatol 2005;3:574-80. [CrossRef]
  • Bahloul M, Chaari A, Khlaf-Bouaziz N, Kallel H, Chaari L, Ben Hamida C, et al. Coeliac disease cerebral venous thrombosis and protein S deficiency, a fortuitous associaton? J Mal Vasc 2005;30:228-30. [CrossRef]
  • Kallel L, Matri S, Karoui S, Fekih M, Boubaker J and Filali A. Deep Venous Thrombosis Related to Protein S Deficiency Revealing Celiac Disease. Am J Gastroenterol 2009;104:256-7. [CrossRef]
  • Ouakaa-Kchaou A, Ennaifer R, Belhadi N, Garoouri D, Elloumi H, Romani M, et al. Celiac disease associated with Budd-Chiari syndrome. Presse Med 2008;37:239-41.
There are 15 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Gökhan Çelik This is me

Aydın Çiledağ This is me

Onur Keskin This is me

Arzu Ensari This is me

Ayça Karabörk This is me

Akın Kaya This is me

Publication Date April 1, 2011
Published in Issue Year 2011 Volume: 2011 Issue: 4

Cite

APA Çelik, G., Çiledağ, A., Keskin, O., Ensari, A., et al. (2011). Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association. Balkan Medical Journal, 2011(4), 450-452. https://doi.org/10.5174/tutfd.2010.03637.1
AMA Çelik G, Çiledağ A, Keskin O, Ensari A, Karabörk A, Kaya A. Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association. Balkan Medical Journal. April 2011;2011(4):450-452. doi:10.5174/tutfd.2010.03637.1
Chicago Çelik, Gökhan, Aydın Çiledağ, Onur Keskin, Arzu Ensari, Ayça Karabörk, and Akın Kaya. “Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: A Rare Association”. Balkan Medical Journal 2011, no. 4 (April 2011): 450-52. https://doi.org/10.5174/tutfd.2010.03637.1.
EndNote Çelik G, Çiledağ A, Keskin O, Ensari A, Karabörk A, Kaya A (April 1, 2011) Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association. Balkan Medical Journal 2011 4 450–452.
IEEE G. Çelik, A. Çiledağ, O. Keskin, A. Ensari, A. Karabörk, and A. Kaya, “Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association”, Balkan Medical Journal, vol. 2011, no. 4, pp. 450–452, 2011, doi: 10.5174/tutfd.2010.03637.1.
ISNAD Çelik, Gökhan et al. “Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: A Rare Association”. Balkan Medical Journal 2011/4 (April 2011), 450-452. https://doi.org/10.5174/tutfd.2010.03637.1.
JAMA Çelik G, Çiledağ A, Keskin O, Ensari A, Karabörk A, Kaya A. Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association. Balkan Medical Journal. 2011;2011:450–452.
MLA Çelik, Gökhan et al. “Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: A Rare Association”. Balkan Medical Journal, vol. 2011, no. 4, 2011, pp. 450-2, doi:10.5174/tutfd.2010.03637.1.
Vancouver Çelik G, Çiledağ A, Keskin O, Ensari A, Karabörk A, Kaya A. Sarcoidosis, Celiac Disease and Deep Venous Thrombosis: a Rare Association. Balkan Medical Journal. 2011;2011(4):450-2.