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The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial

Year 2012, Volume: 2012 Issue: 2, 184 - 187, 01.02.2012
https://doi.org/10.5152/balkanmedj.2012.003

Abstract

Objective: Botulinum toxin type-A (BoNTA) has been considered a treatment option for CH. The aim of this study was to assess the effectiveness of BoNTA treatment in patients with medically resistant CH. Materials and Methods: Forty patients with CH were included in the study. Patients in the BoNTA group (n=20) were administered 10 U of BoNTA bilaterally to the frontal muscles, 20 U to the temporal muscles, 15 U to the semispinalis capitis, 15 U to the splenius capitis, and 15 U to the trapezius muscles (total: 150 U). Patients in the placebo group (n=20) received 0.2 mL of saline administrated to the same sites. All participations were evaluated 6 and 12 weeks after treatment; side effects, the number of painful days, severity (by visual analogue scale, VAS) and frequency of pain were evaluated. Results: In the BoNTA group, the severity and frequency of pain 6 and 12 weeks post treatment were significantly lower than pre-treatment levels (p<0.05). At 12 weeks post treatment, the severity and frequency of pain in the BoNTA group were lower than in the placebo group (p<0.05). Conclusion: The findings suggest that BoNTA was an effective treatment for CH.

References

  • Sjaastad O, Saunte C, Hovdahl H, Breivik H, Grİnbaek E. “Cervi- cogenic” headache. An hypothesis. Cephalalgia 1983;3:249-56. [CrossRef]
  • Fredriksen TA, Hovdal H, Sjaastad O. “Cervicogenic headache”: clinical manifestation. Cephalalgia 1987;7:147-60. [CrossRef]
  • IHS, Headache Classification Committee of the International Headache Society. The international Classification of headache disorders:2nd edition. Cephalalgia 2004;24:9-160.
  • Wight S, Osborne N, Breen AC. Incidence of ponticulus posterior of the atlas in migraine and cervicogenic headache. J Manipul Physiol Ther 1999;22:15-20. [CrossRef]
  • Hack G. Cervicogenic headache: new anatomical discovery pro- vides the missing link. Chiroprac Rep 1998;12:1-3.
  • Mitchell BS, Humphreys BK, O’Sullivan E. Attachments of the lig- amentum nuchae to cervical posterior spinal dura and the lateral part of the occipital bone. J Manipul Physiol Ther 1998;21:145-8.
  • Alix ME, Bates DK. A proposed etiology of cervicogenic head- ache: the neurophysiologic basis and anatomic relationship between the dura mater and the rectus posterior capitis minor muscle. J Manipul Physiol Ther 1999;22:534-9. [CrossRef]
  • Leone M, D’Amico D, Moschiano F, Farinotti M, Filippini G, Bus- sone G. Possible identification of cervicogenic headache among patients with migraine: an analysis of 374 headaches. Headache 1995;35:461-4. [CrossRef]
  • Rothbart P. Cervicogenic headache: a pain in the neck. Can J Diagnos 1996;13:64-6.
  • Sjaastad O, Fredriksen TA. Cervicogenic headache: criteria, clas- sification and epidemiology. Clin Exp Rheumatol 2000;18:3-6.
  • Nilsson N. The prevalence of cervicogenic headache in a random population sample of 20-59 year olds. Spine 1995;20:1884-8. [CrossRef]
  • IHS, Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for head- ache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988;8:1-96.
  • Kränzlin P, Wälchli B. The concept of cervicogenic headache. An- nual postgraduate course of the association of Swiss chiroprac- tors, vol. 13. Interlaken, Switzerland: 1993.
  • Anthony M. Cervicogenic headache: prevalence and response to local steroid therapy. Clin Exp Rheumatol 2000;18:59-64.
  • Shah PA, Nafee A. Clinical profile of headache and cranial neural- gias. J Assoc Physicians India 1999;47:1072-5.
  • Bono G, Antonaci F, Ghirmai S, D’Angelo F, Berger M, Nappi G. Whiplash injuries: clinical picture and diagnostic work-up. Clin Exp Rheumatol 2000;18:23-8.
  • Oqince M, Hall T, Robinson K, Blackmore AM. The diagnostic validity of the cervical flexion-rotation test in C1/C2 related cervi- cogenic headache. Man Ther 2007;12:256-62. [CrossRef]
  • Bovim G. Cervicogenic headache: Studies on clinical, anatomical and differential diagnostic factors. Tapir, Trondheim 1993.
  • Sjaastad O, Fredriksen T.A, Bono G, Nappi G. Cervicogenic Headache, Basic Consepts.European Headache Federation. Smith-Gordon, London 2003.
  • Bovim G, Berg R, Dale LG. Cervicogenic headache: anesthetic blockades of cervical nerves (C2-C5) and facet joint (C2/C3). Pain 1992;49:315-20. [CrossRef]
  • Freund BJ, Schwartz M. Treatment of chronic cervical-associat- ed headache with botulinum toxin A: a pilot study. Headache 2000;40:231-6. [CrossRef]
  • Sand T, Bovim G, Helde G. Intracutaneous sterile water injections do not relieve pain in cervicogenic headache. Acta Neurol Scand 1992;86:526-8. [CrossRef]
  • Hobson DE, Gladish DF. Botulinum toxin injection for cervico- genic headache. Headache 1997;37:253-5. [CrossRef]
  • Whittingham W, Ellis WB, Molyneux TP. The effect of manipu- lation (toggle recoil technique) for headaches with upper cer- vical joint dysfunction: a pilot study. J Manipul Physiol Ther 1994;17:369-75.
  • Vernon HT. Spinal manipulation and headaches of cervical origin. J Manipul Physiol Ther 1989;12:455-68.
  • Farina S, Granella F, Malferrari G, Manzoni GC. Headache and cervical spine disorders: classification and treatment with trans- cutaneous electrical nerve stimulation. Headache 1986;26:431-3. [CrossRef]
  • Nilsson N. A randomized controlled trial of the effect of spinal manipulation in the treatment of cervicogenic headache. J Ma- nipul Physiol Ther 1995;18:435-40.
  • Nilsson N, Christensen HW, Hartvigsen J. The effect of spinal ma- nipulation in the treatment of cervicogenic headache. J Manipul Physiol Ther 1997;20:326-30.
  • Howe D, Newcombe R, Wade M. Manipulation of the cervical spine a pilot study. J R Coll Gen Pract 1983;33:574-9.
  • Evers S, Rahmann A, Vollmer-Haase J, Husstedt IW. Treatment of headache with botulinum toxin A--a review according to ev- idence-based medicine criteria. Cephalalgia 2002;22:699-710. [CrossRef]
  • Schnider P, Moraru E, Bittner C, Vigl M, Wöber C, Maly J et al. Physical therapy and botulinum toxin type A in patients with cervical associated headache according to IHS criteria: double- blind, placebocontrolled study. Neurology 2001;56:A349.
  • Evers S. Status on the use of botulinum toxin for headache disor- ders. Curr Opin Neurol 2006;19:310-5.
  • Brunton LL, Lazo JS, Parker KL. Goodman & Gilman’s Teda- vinin farmakolojik temeli. Süzer Ö, Akın D, Süzer AH, Dedeoğlu BD, Küçükhüseyin C. (Çevirenler) 1. Baskı, İstanbul: Nobel Matbaacılık, 2009;225-30.
  • Colhado OC, Boeing M, Ortega LB. Botulinum toxin in pain treat- ment.Rev Bras Anestesiol 2009;59:366-81.
  • Aoki KR. Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology 2005;26:785-93. [CrossRef]
  • Mathew NT, Frishberg BM, Gawel M, Dimitrova R, Gibson J, Turkel C. Botulinum toxin type A (BOTOX) for the prophylactic treatment of chronic daily headache: A randomized, double- blind, placebo-controlled trial. Headache 2005;45:293-307. [CrossRef]
  • Dodick DW, Mauskop A, Elkind AH, DeGryse R, Brin MF, Silber- stein SD; BOTOX CDH Study Group. Botulinum Toxin Type A for the Prophylaxis of Chronic Daily Headache: Subgroup Analysis of Patients Not Receiving Other Prophylactic Medications: A Randomized Double-Blind, Placebo-Controlled Study. Headache 2005;45:315-24. [CrossRef]

The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial

Year 2012, Volume: 2012 Issue: 2, 184 - 187, 01.02.2012
https://doi.org/10.5152/balkanmedj.2012.003

Abstract

References

  • Sjaastad O, Saunte C, Hovdahl H, Breivik H, Grİnbaek E. “Cervi- cogenic” headache. An hypothesis. Cephalalgia 1983;3:249-56. [CrossRef]
  • Fredriksen TA, Hovdal H, Sjaastad O. “Cervicogenic headache”: clinical manifestation. Cephalalgia 1987;7:147-60. [CrossRef]
  • IHS, Headache Classification Committee of the International Headache Society. The international Classification of headache disorders:2nd edition. Cephalalgia 2004;24:9-160.
  • Wight S, Osborne N, Breen AC. Incidence of ponticulus posterior of the atlas in migraine and cervicogenic headache. J Manipul Physiol Ther 1999;22:15-20. [CrossRef]
  • Hack G. Cervicogenic headache: new anatomical discovery pro- vides the missing link. Chiroprac Rep 1998;12:1-3.
  • Mitchell BS, Humphreys BK, O’Sullivan E. Attachments of the lig- amentum nuchae to cervical posterior spinal dura and the lateral part of the occipital bone. J Manipul Physiol Ther 1998;21:145-8.
  • Alix ME, Bates DK. A proposed etiology of cervicogenic head- ache: the neurophysiologic basis and anatomic relationship between the dura mater and the rectus posterior capitis minor muscle. J Manipul Physiol Ther 1999;22:534-9. [CrossRef]
  • Leone M, D’Amico D, Moschiano F, Farinotti M, Filippini G, Bus- sone G. Possible identification of cervicogenic headache among patients with migraine: an analysis of 374 headaches. Headache 1995;35:461-4. [CrossRef]
  • Rothbart P. Cervicogenic headache: a pain in the neck. Can J Diagnos 1996;13:64-6.
  • Sjaastad O, Fredriksen TA. Cervicogenic headache: criteria, clas- sification and epidemiology. Clin Exp Rheumatol 2000;18:3-6.
  • Nilsson N. The prevalence of cervicogenic headache in a random population sample of 20-59 year olds. Spine 1995;20:1884-8. [CrossRef]
  • IHS, Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for head- ache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988;8:1-96.
  • Kränzlin P, Wälchli B. The concept of cervicogenic headache. An- nual postgraduate course of the association of Swiss chiroprac- tors, vol. 13. Interlaken, Switzerland: 1993.
  • Anthony M. Cervicogenic headache: prevalence and response to local steroid therapy. Clin Exp Rheumatol 2000;18:59-64.
  • Shah PA, Nafee A. Clinical profile of headache and cranial neural- gias. J Assoc Physicians India 1999;47:1072-5.
  • Bono G, Antonaci F, Ghirmai S, D’Angelo F, Berger M, Nappi G. Whiplash injuries: clinical picture and diagnostic work-up. Clin Exp Rheumatol 2000;18:23-8.
  • Oqince M, Hall T, Robinson K, Blackmore AM. The diagnostic validity of the cervical flexion-rotation test in C1/C2 related cervi- cogenic headache. Man Ther 2007;12:256-62. [CrossRef]
  • Bovim G. Cervicogenic headache: Studies on clinical, anatomical and differential diagnostic factors. Tapir, Trondheim 1993.
  • Sjaastad O, Fredriksen T.A, Bono G, Nappi G. Cervicogenic Headache, Basic Consepts.European Headache Federation. Smith-Gordon, London 2003.
  • Bovim G, Berg R, Dale LG. Cervicogenic headache: anesthetic blockades of cervical nerves (C2-C5) and facet joint (C2/C3). Pain 1992;49:315-20. [CrossRef]
  • Freund BJ, Schwartz M. Treatment of chronic cervical-associat- ed headache with botulinum toxin A: a pilot study. Headache 2000;40:231-6. [CrossRef]
  • Sand T, Bovim G, Helde G. Intracutaneous sterile water injections do not relieve pain in cervicogenic headache. Acta Neurol Scand 1992;86:526-8. [CrossRef]
  • Hobson DE, Gladish DF. Botulinum toxin injection for cervico- genic headache. Headache 1997;37:253-5. [CrossRef]
  • Whittingham W, Ellis WB, Molyneux TP. The effect of manipu- lation (toggle recoil technique) for headaches with upper cer- vical joint dysfunction: a pilot study. J Manipul Physiol Ther 1994;17:369-75.
  • Vernon HT. Spinal manipulation and headaches of cervical origin. J Manipul Physiol Ther 1989;12:455-68.
  • Farina S, Granella F, Malferrari G, Manzoni GC. Headache and cervical spine disorders: classification and treatment with trans- cutaneous electrical nerve stimulation. Headache 1986;26:431-3. [CrossRef]
  • Nilsson N. A randomized controlled trial of the effect of spinal manipulation in the treatment of cervicogenic headache. J Ma- nipul Physiol Ther 1995;18:435-40.
  • Nilsson N, Christensen HW, Hartvigsen J. The effect of spinal ma- nipulation in the treatment of cervicogenic headache. J Manipul Physiol Ther 1997;20:326-30.
  • Howe D, Newcombe R, Wade M. Manipulation of the cervical spine a pilot study. J R Coll Gen Pract 1983;33:574-9.
  • Evers S, Rahmann A, Vollmer-Haase J, Husstedt IW. Treatment of headache with botulinum toxin A--a review according to ev- idence-based medicine criteria. Cephalalgia 2002;22:699-710. [CrossRef]
  • Schnider P, Moraru E, Bittner C, Vigl M, Wöber C, Maly J et al. Physical therapy and botulinum toxin type A in patients with cervical associated headache according to IHS criteria: double- blind, placebocontrolled study. Neurology 2001;56:A349.
  • Evers S. Status on the use of botulinum toxin for headache disor- ders. Curr Opin Neurol 2006;19:310-5.
  • Brunton LL, Lazo JS, Parker KL. Goodman & Gilman’s Teda- vinin farmakolojik temeli. Süzer Ö, Akın D, Süzer AH, Dedeoğlu BD, Küçükhüseyin C. (Çevirenler) 1. Baskı, İstanbul: Nobel Matbaacılık, 2009;225-30.
  • Colhado OC, Boeing M, Ortega LB. Botulinum toxin in pain treat- ment.Rev Bras Anestesiol 2009;59:366-81.
  • Aoki KR. Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology 2005;26:785-93. [CrossRef]
  • Mathew NT, Frishberg BM, Gawel M, Dimitrova R, Gibson J, Turkel C. Botulinum toxin type A (BOTOX) for the prophylactic treatment of chronic daily headache: A randomized, double- blind, placebo-controlled trial. Headache 2005;45:293-307. [CrossRef]
  • Dodick DW, Mauskop A, Elkind AH, DeGryse R, Brin MF, Silber- stein SD; BOTOX CDH Study Group. Botulinum Toxin Type A for the Prophylaxis of Chronic Daily Headache: Subgroup Analysis of Patients Not Receiving Other Prophylactic Medications: A Randomized Double-Blind, Placebo-Controlled Study. Headache 2005;45:315-24. [CrossRef]
There are 37 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Ömer Karadaş This is me

Bilgin Öztürk This is me

Ümit Hıdır Ulaş This is me

Yaşar Kütükçü This is me

Zeki Odabaşı This is me

Publication Date February 1, 2012
Published in Issue Year 2012 Volume: 2012 Issue: 2

Cite

APA Karadaş, Ö., Öztürk, B., Ulaş, Ü. H., Kütükçü, Y., et al. (2012). The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial. Balkan Medical Journal, 2012(2), 184-187. https://doi.org/10.5152/balkanmedj.2012.003
AMA Karadaş Ö, Öztürk B, Ulaş ÜH, Kütükçü Y, Odabaşı Z. The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial. Balkan Medical Journal. February 2012;2012(2):184-187. doi:10.5152/balkanmedj.2012.003
Chicago Karadaş, Ömer, Bilgin Öztürk, Ümit Hıdır Ulaş, Yaşar Kütükçü, and Zeki Odabaşı. “The Efficacy of Botulinum Toxin in Patients With Cervicogenic Headache: A Placebo-Controlled Clinical Trial”. Balkan Medical Journal 2012, no. 2 (February 2012): 184-87. https://doi.org/10.5152/balkanmedj.2012.003.
EndNote Karadaş Ö, Öztürk B, Ulaş ÜH, Kütükçü Y, Odabaşı Z (February 1, 2012) The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial. Balkan Medical Journal 2012 2 184–187.
IEEE Ö. Karadaş, B. Öztürk, Ü. H. Ulaş, Y. Kütükçü, and Z. Odabaşı, “The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial”, Balkan Medical Journal, vol. 2012, no. 2, pp. 184–187, 2012, doi: 10.5152/balkanmedj.2012.003.
ISNAD Karadaş, Ömer et al. “The Efficacy of Botulinum Toxin in Patients With Cervicogenic Headache: A Placebo-Controlled Clinical Trial”. Balkan Medical Journal 2012/2 (February 2012), 184-187. https://doi.org/10.5152/balkanmedj.2012.003.
JAMA Karadaş Ö, Öztürk B, Ulaş ÜH, Kütükçü Y, Odabaşı Z. The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial. Balkan Medical Journal. 2012;2012:184–187.
MLA Karadaş, Ömer et al. “The Efficacy of Botulinum Toxin in Patients With Cervicogenic Headache: A Placebo-Controlled Clinical Trial”. Balkan Medical Journal, vol. 2012, no. 2, 2012, pp. 184-7, doi:10.5152/balkanmedj.2012.003.
Vancouver Karadaş Ö, Öztürk B, Ulaş ÜH, Kütükçü Y, Odabaşı Z. The Efficacy of Botulinum Toxin in Patients with Cervicogenic Headache: a Placebo-Controlled Clinical Trial. Balkan Medical Journal. 2012;2012(2):184-7.