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Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer

Year 2014, Volume: 2014 Issue: 2, 154 - 157, 07.08.2014
https://doi.org/10.5152/balkanmedj.2014.13122

Abstract

Background: Cervical cancer is the second most common female malignancy worldwide. Although its incidence has decreased in developed countries due to screening with Papanicolaou test, it is still the leading cause of cancer-related female death in developing countries. Aims: The aim of this study was to determine whether the apparent diffusion coefficient (ADC) measurements calculated from diffusion-weighted imaging (DWI) images had any contribution in differentiation of normal cervical tissue from malignant lesions preoperatively, and whether there was a correlation between the mean ADC values and tumor type, grade, or stage in malignant lesions. Study Design: Case-control study. Methods: Mean ADC values in 25 patients who had cervical cancer proved histopathologically, and 20 patients with otherwise normal uterus were compared. Also in the study group, mean ADC values were compared between histopathologic subtypes, tumor grades, and stages. Results: In the study group the mean ADC values (0.96±0.15x10-3 mm2/s) were statistically lower than that of the control group (1.67±0.17x10-3 mm2/s) (p<0.05). According to histopathologic subtypes there was no significant difference between mean ADC values of squamous cell cancer and adenocarcinoma (0.95x10-3 mm2/s and 0.91x10-3 mm2/s, respectively) (p>0.05). There was also no significant difference between the mean ADC values of the tumor grades (p>0.05). The mean ADC values in early stage cervical cancer (0.86±0.05x10-3 mm2/s) were significantly lower than the mean ADC values in late stage disease (0.98±0.06x10-3 mm2/s) (p<0.05). Conclusion: ADC value measurements may provide useful information in diagnosis of cervical cancer as well as in preoperative assessment of the tumor stage.

References

  • Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-9. [CrossRef]
  • Solomon D, Breen N, McNeel T. Cervical cancer screening rates in the United States and the potential impact of implementation of screening guidelines. CA Cancer J Clin 2007;57:105-11. [CrossRef]
  • Schiffman MH, Bauer HM, Hoover RN. Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst 1993;85:958-64. [CrossRef] Early stage (n=11) Late stage (n=14)
  • Balkan Med J, Vol. 31, No. 2, 2014
  • Demirbaş et al. Contribution of Diffusion-Weighted Imaging

Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer

Year 2014, Volume: 2014 Issue: 2, 154 - 157, 07.08.2014
https://doi.org/10.5152/balkanmedj.2014.13122

Abstract

References

  • Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-9. [CrossRef]
  • Solomon D, Breen N, McNeel T. Cervical cancer screening rates in the United States and the potential impact of implementation of screening guidelines. CA Cancer J Clin 2007;57:105-11. [CrossRef]
  • Schiffman MH, Bauer HM, Hoover RN. Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst 1993;85:958-64. [CrossRef] Early stage (n=11) Late stage (n=14)
  • Balkan Med J, Vol. 31, No. 2, 2014
  • Demirbaş et al. Contribution of Diffusion-Weighted Imaging
There are 5 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Tuna Demirbaş This is me

Tan Cimilli This is me

Sibel Bayramoğlu This is me

Nurten Turan Güner This is me

Elif Hocaoğlu This is me

Ercan İnci This is me

Publication Date August 7, 2014
Published in Issue Year 2014 Volume: 2014 Issue: 2

Cite

APA Demirbaş, T., Cimilli, T., Bayramoğlu, S., Güner, N. T., et al. (2014). Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer. Balkan Medical Journal, 2014(2), 154-157. https://doi.org/10.5152/balkanmedj.2014.13122
AMA Demirbaş T, Cimilli T, Bayramoğlu S, Güner NT, Hocaoğlu E, İnci E. Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer. Balkan Medical Journal. February 2014;2014(2):154-157. doi:10.5152/balkanmedj.2014.13122
Chicago Demirbaş, Tuna, Tan Cimilli, Sibel Bayramoğlu, Nurten Turan Güner, Elif Hocaoğlu, and Ercan İnci. “Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer”. Balkan Medical Journal 2014, no. 2 (February 2014): 154-57. https://doi.org/10.5152/balkanmedj.2014.13122.
EndNote Demirbaş T, Cimilli T, Bayramoğlu S, Güner NT, Hocaoğlu E, İnci E (February 1, 2014) Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer. Balkan Medical Journal 2014 2 154–157.
IEEE T. Demirbaş, T. Cimilli, S. Bayramoğlu, N. T. Güner, E. Hocaoğlu, and E. İnci, “Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer”, Balkan Medical Journal, vol. 2014, no. 2, pp. 154–157, 2014, doi: 10.5152/balkanmedj.2014.13122.
ISNAD Demirbaş, Tuna et al. “Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer”. Balkan Medical Journal 2014/2 (February 2014), 154-157. https://doi.org/10.5152/balkanmedj.2014.13122.
JAMA Demirbaş T, Cimilli T, Bayramoğlu S, Güner NT, Hocaoğlu E, İnci E. Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer. Balkan Medical Journal. 2014;2014:154–157.
MLA Demirbaş, Tuna et al. “Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer”. Balkan Medical Journal, vol. 2014, no. 2, 2014, pp. 154-7, doi:10.5152/balkanmedj.2014.13122.
Vancouver Demirbaş T, Cimilli T, Bayramoğlu S, Güner NT, Hocaoğlu E, İnci E. Contribution of Diffusion-Weighted Imaging to Diagnosis and Staging of Cervical Cancer. Balkan Medical Journal. 2014;2014(2):154-7.