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Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy

Year 2014, Volume: 2014 Issue: 2, 173 - 176, 07.08.2014
https://doi.org/10.5152/balkanmedj.2014.13155

Abstract

Background: Ganglioneuroblastomas (GNBs) are rare embryonic neoplasms in the spectrum of neuroblastic tumours and 80% of cases occur in the first decade. In adults, GNBs are usually located in the retroperitoneum, mediastinum and neck but intracranial GNBs are extremely rare. Case Report: A 34-year-old male applied to the Department of Neurology outpatient clinic with a two month history of headache and numbness in his legs. Detailed examinations and cranial CT were performed and showed a mass with a 5 cm diameter running from the third to the fourth ventricle. Referral to a neurosurgeon was performed for partial removal of the tumour, as the histological and immunohistochemical studies defined the diagnosis of GNB. Three months later, when the patient experienced dizziness, an MRI was performed, which showed a 4x3 cm ventricular mass, with hypointense characterisation in T1-weighted and hyperintense characteristics in T2-weighted and flair sequences. Afterwards, fractioned radiotherapy (54 Gy/30 fx) was chosen as the appropriate therapy. In the follow-up period, MRI was performed 3 months and 1 year after treatment, and revealed shrinkage of the tumour by at least 50%. Meanwhile the patient's post-irradiation course was favourable. Conclusion: Data following the use of radiotherapy as treatment for intracranial GNB showing favourable results has been reported.

References

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  • 4. Rorke LB, Hart MN, McLendon RE. Supratentorial primitive neuroectodermal tumour (PNET). In: Kleihues P, Cavenee WK, editors. Pathology and genetics of tumours of the nervous system. Lyon: IARC Press; 2000:141-4.
  • 5. Sibilla L, Martelli A, Farina L, Uggetti C, Zappoli F, Sessa F, et al. Gangliooneuroblastoma of the spinal cord. AJNR Am J Neuroradiol 1995;16:875-7.
  • 6. Feigin I, Cohen M . Maturation and anaplasia in neuronal tumors of the peripheral nervous system, with observation on the glial like tissues in the ganglioneuroblastoma. J Neuropathol Exp Neurol 1977;36:748-63. [CrossRef]
  • 7. Tanaka M, Shibui S, Nomura K, Nakanishi Y. Pineal ganglioneuroblastoma in an adult. J Neurooncol 1999;44:169-73. [CrossRef]
  • 8. Pearl GS, Mirra SS, Miles ML. Intracerebral ganglioneuroblastoma with intracytoplasmic mıcrotubular aggregates: case report and ultrastructural study. Ultrastruct Pathol 1981;2:337-42. [CrossRef]
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  • 10. Nakajima F, Kuwabara T, Yagishita S. Primary cerebral ganglioneuroblastoma. Neurol Med Chir (Tokyo) 1983;23: 301-4. [CrossRef]
  • 11. Nishihara H, Ozaki Y, Ito T, Yoshinaga T, Tabu K, Tanino M, et al. A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. Brain Tumor Pathol 2008;25:45-9. [CrossRef]
  • 12. Sabatino G, Lauriola L, Sioletic S, Puca A. Occipital ganglioneuroblastoma in an adult. Acta Neurochir (Wien) 2009;151:495-6. [CrossRef]
  • 13. Sanli M, Gurkanlar D, Yildiz B, Sekerci Z. Ten years of experience in the surgery of lateral and third ventricletumors. Türk Nörosirürji Dergisi 2003;13:12-7.

Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy

Year 2014, Volume: 2014 Issue: 2, 173 - 176, 07.08.2014
https://doi.org/10.5152/balkanmedj.2014.13155

Abstract

References

  • 1. Perez Carlos A, Halperin Edward C, Brady Luther W. Pediatric tumorsneuroblastoma. In: Principles and practice of radiation oncology. 5th edition. Baltimore: Lippincott Williams & Wilkins; 2008:1860.
  • 2. Nakazato Y, Hosaka N. A 32 year-old man with left temporal lobe tumour. Neuropathol 2004;24:261-2. [CrossRef]
  • 3. Kilton LJ, Aschenbrener C, Burns CP. Ganglioneuroblastoma in adults. Cancer 1976;37:974-83. [CrossRef]
  • 4. Rorke LB, Hart MN, McLendon RE. Supratentorial primitive neuroectodermal tumour (PNET). In: Kleihues P, Cavenee WK, editors. Pathology and genetics of tumours of the nervous system. Lyon: IARC Press; 2000:141-4.
  • 5. Sibilla L, Martelli A, Farina L, Uggetti C, Zappoli F, Sessa F, et al. Gangliooneuroblastoma of the spinal cord. AJNR Am J Neuroradiol 1995;16:875-7.
  • 6. Feigin I, Cohen M . Maturation and anaplasia in neuronal tumors of the peripheral nervous system, with observation on the glial like tissues in the ganglioneuroblastoma. J Neuropathol Exp Neurol 1977;36:748-63. [CrossRef]
  • 7. Tanaka M, Shibui S, Nomura K, Nakanishi Y. Pineal ganglioneuroblastoma in an adult. J Neurooncol 1999;44:169-73. [CrossRef]
  • 8. Pearl GS, Mirra SS, Miles ML. Intracerebral ganglioneuroblastoma with intracytoplasmic mıcrotubular aggregates: case report and ultrastructural study. Ultrastruct Pathol 1981;2:337-42. [CrossRef]
  • 9. Hosaka T, Nukui H, Koizumi H, Miyazaki M. Ganglioneuroblastoma of the anterior skull base with a long term follow-up. Case Report. Neurol Med Chir (Tokyo) 1982;22:757-62. [CrossRef]
  • 10. Nakajima F, Kuwabara T, Yagishita S. Primary cerebral ganglioneuroblastoma. Neurol Med Chir (Tokyo) 1983;23: 301-4. [CrossRef]
  • 11. Nishihara H, Ozaki Y, Ito T, Yoshinaga T, Tabu K, Tanino M, et al. A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. Brain Tumor Pathol 2008;25:45-9. [CrossRef]
  • 12. Sabatino G, Lauriola L, Sioletic S, Puca A. Occipital ganglioneuroblastoma in an adult. Acta Neurochir (Wien) 2009;151:495-6. [CrossRef]
  • 13. Sanli M, Gurkanlar D, Yildiz B, Sekerci Z. Ten years of experience in the surgery of lateral and third ventricletumors. Türk Nörosirürji Dergisi 2003;13:12-7.
There are 13 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Mustafa Akın This is me

Şefika Arzu Ergen This is me

Büge Öz This is me

Gülyüz Atkovar This is me

İsmet Şahinler This is me

Publication Date August 7, 2014
Published in Issue Year 2014 Volume: 2014 Issue: 2

Cite

APA Akın, M., Ergen, Ş. A., Öz, B., Atkovar, G., et al. (2014). Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy. Balkan Medical Journal, 2014(2), 173-176. https://doi.org/10.5152/balkanmedj.2014.13155
AMA Akın M, Ergen ŞA, Öz B, Atkovar G, Şahinler İ. Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy. Balkan Medical Journal. February 2014;2014(2):173-176. doi:10.5152/balkanmedj.2014.13155
Chicago Akın, Mustafa, Şefika Arzu Ergen, Büge Öz, Gülyüz Atkovar, and İsmet Şahinler. “Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment With Radiotherapy”. Balkan Medical Journal 2014, no. 2 (February 2014): 173-76. https://doi.org/10.5152/balkanmedj.2014.13155.
EndNote Akın M, Ergen ŞA, Öz B, Atkovar G, Şahinler İ (February 1, 2014) Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy. Balkan Medical Journal 2014 2 173–176.
IEEE M. Akın, Ş. A. Ergen, B. Öz, G. Atkovar, and İ. Şahinler, “Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy”, Balkan Medical Journal, vol. 2014, no. 2, pp. 173–176, 2014, doi: 10.5152/balkanmedj.2014.13155.
ISNAD Akın, Mustafa et al. “Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment With Radiotherapy”. Balkan Medical Journal 2014/2 (February 2014), 173-176. https://doi.org/10.5152/balkanmedj.2014.13155.
JAMA Akın M, Ergen ŞA, Öz B, Atkovar G, Şahinler İ. Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy. Balkan Medical Journal. 2014;2014:173–176.
MLA Akın, Mustafa et al. “Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment With Radiotherapy”. Balkan Medical Journal, vol. 2014, no. 2, 2014, pp. 173-6, doi:10.5152/balkanmedj.2014.13155.
Vancouver Akın M, Ergen ŞA, Öz B, Atkovar G, Şahinler İ. Ventricular Ganglioneuroblastoma in an Adult and Successful Treatment with Radiotherapy. Balkan Medical Journal. 2014;2014(2):173-6.